Low T cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS: Correlation with decreased CD28 expression

Clinical and Experimental Immunology

Volumn 105, Issue 3, 1996, Pages 409-415

  Roos, M T H L ^a   Miedema, F ^a   Meinesz, A A P ^a   De Leeuw, N A S M ^a   Pakker, N G ^a   Lange, J M A ^a   Coutinho, R A ^b   Schellekens, P Th A ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MUNICIPAL HEALTH SERVICE   (Netherlands)

^c CENTRAL LABORATORY   (Netherlands)

Author keywords

CD28 expression; Combined CD3 plus CD28 MoAb; HIV 1; Marker; Prognostic; T cell function

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; MONOCLONAL ANTIBODY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0029824382     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-794.x     Document Type: Article

References (32)

1. Fahey JL, Prince HE, Weaver M, Groopman J, Visscher H, Schwartz K, Detels R. Quantitative changes in T helper or suppressor cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subsets disorders. JAMA 1984; 76:95-100.
2. Melbye M, Biggar RJ, Ebbesen P et al. Long-term seropositivity for human T-lymphotropic virus type III in homosexual men without the acquired immunodeficiency syndrome: development of immunologic and clinical abnormalities. Ann Intern Med 1986; 104:496-500.
3. Kornfeld H, Vande Stouwe RA, Lange M, Reddy MM, Griego MH. T-lymphocyte subpopulations in homosexual men. N Engl J Med 1982; 307:1563-6.
4. Hersh EM, Mansell PWA, Reuben JM. Leukocyte subset analysis and related immunological findings in acquired immunodeficiency disease syndrome (AIDS) and malignancies. Diagn Immunol 1983; 1:168-73.
5. Walker CM, Moody DJ, Stites DP, Levy JA. CD8 lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986; 234:1563-6.
6. Lane HC, Depper JL, Greene WC, Whalen G, Waldmann TA, Fauci AS. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. N Engl J Med 1985; 313:79-84.
7. Shearer GM, Bernstein DC, Tung KSK, Via CS, Redfield R, Salahuddin SZ, Gallo RC. A model for the selective loss of major histocompatibility complex self-restricted T cell immune responses during the development of acquired immune deficiency syndrome (AIDS). J Immunol 1986; 137:2514-21.
8. Giorgi JV, Fahey JL, Smith DC, Hultin LE, Cheng HL, Mitsuyasu RT, Detels R. Early effects of HIV on CD4 lymphocytes in vivo. J Immunol 1987; 138:3725-30.
9. Ballet JJ, Couderc LJ, Rabian-Herzog C, Duval-Roy C, Janier M, Danon F, Clauvel JP, Seligmann M. Impaired T-lymphocyte-dependent immune responses to microbial antigens in patients with HIV-1-associated persistent generalized lymphadenopathy. AIDS 1988; 2:291-7.
10. + T helper cell depletion occurs. J Clin Invest 1988; 82:1908-14.
11. Bentin J, Tsoukas C, McCutchan JA, Spector SE, Richman DD, Vaughan JH. Impairment in T-lymphocyte responses during early infection with the human immunodeficiency virus. J Clin Immunol 1989; 9:159-68.
12. Schellekens PThA, Roos MThL, De Wolf F, Lange JMA, Miedema F. Low T-cell responsiveness to activation via CD3 TCR is a prognostic marker for AIDS in HIV-1 infected men. J Clin Immunol 1990; 10:121-7.
13. Hofmann B, Orskov Lindhardt B, Gerstoft J et al. Lmphocyte transformation response to pokeweed mitogen as a marker for the development of AIDS and AIDS related symptoms in homosexual men with HIV antibodies. Br Med J 1987; 295:293-6.
14. Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7 BB-1. Proc Natl Acad Sci USA 1990; 87:5031-5.
15. June CH, Ledbetter JA, Linsley PS, Thompson CB. Role of the CD28 receptor in T-cell activation. Immunol Today 1990; 11:211-6.
16. Van Lier RAW, Brouwer M, deJong R, Groot M, de Groot E, Aarden LA. Functional properties of the human T-cell differentiatiation antigen CD28. In: Knapp W, ed. Leukocyte typing. Vol. IV. Oxford: Oxford University Press, 1989.
17. + T helper subsets. J Immunol 1992; 149:2795-802.
18. Gruters RA, Terpstra FG, De Goede REY et al. Immunological and virological markers in individuals progressing from seroconversion to AIDS. AIDS 1991; 5:837-44.
19. + T cells in HIV disease and following in vitro activation. In: Schlossman SF, ed. Leucocyte typing V. Oxford: Oxford University Press, 1995:446-61.
20. Borthwick NJ, Bofill M, Gombert WM et al. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28 T cells. AIDS 1994; 8:431-41.
21. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994; 169:730-8.
22. + T cells from HIV-infected subjects. Clin Exp Immunol 1995; 100:425-33.
23. Roos MTL, Miedema F, Koot M, Tersmette M, Schaasberg WP, Coutinho RA, Schellekens PTA. T-cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus (HIV)-infected asymptomatic individuals. J Infect Dis 1995; 171:531-6.
24. + cells and the levels of core antigens of and antibodies to the human immunodeficiency virus as predictors of AIDS among seropositive homosexual men. J Infect Dis 1988; 158:615-22.
25. Centers for disease control. Revision of the CDC surveillance case definition of AIDS. MMWR 1987; 36:3-15.
26. Van Lier RAW, Boot JHA, Verhoeven AJ, De Groot ER, Brouwer MA, Aarden LA. Functional studies with anti-CD3 heavy chain isotype switch variant monoclonal antibodies. J Immunol 1987; 139:2873-9.
27. Van Lier RAW, Brouwer M, Aarden LA. Signals involved in T-cell activation, T-cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies. Eur J Immunol 1988; 18:167-72.
28. Metz CE, 'Basic principles of ROC analysis', seminars in nuclear medicine. Stat Med 1978; 10:283-98.
29. Viaggi S, Frigo AC. Threshold determination methods with diagnostic tests: a practical approach for medical decision making. Poster. ISCB-13 1992:1-12.
30. Peto R, Peto J. Asymptotically efficient rank invariant test procedures (with discussion). J Roy Stat Soc. Series A 1972; 135:185-206.
31. Azuma M, Phillips JH, Lanier LL. CD28 T lymphocytes. Antigenic and functional properties. J Immunol 1993; 4:1147-59.
32. Bloemena E, Roos MThL, van Heijst JLAM, Vossen JMJJ, Schellekens PThA. Whole-blood lymphocyte cultures. J Immunol Methods 1999; 122:161-7.