Interferon-γ upregulates CCR5 expression in cord and adult blood mononuclear phagocytes

Blood

Volumn 93, Issue 4, 1999, Pages 1137-1144

  Hariharan, Deepa ^b   Douglas, Steven D ^b   Lee, Benhur ^b   Lai, Jian Ping ^b   Campbell, Donald E ^b   Ho, Wen Zhe ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA;

ANTIGEN EXPRESSION; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LEUKOCYTE MIGRATION; MONONUCLEAR PHAGOCYTE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REGULATORY MECHANISM; VIRUS INFECTIVITY;

EID: 0033558275     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.4.1137.404a35_1137_1144     Document Type: Article

References (35)

1. Billiau A, Dijkmans R: Interferon-gamma: Mechanism of action and therapeutic potential. Biochem Pharmacol 40:1433, 1990
2. Vyakarnam A, McKeating J, Meager A, Beverley PC: Tumor necrosis factors (alpha, beta) induced by human immunodeficiency-1 in peripheral blood mononuclear cells potentiate virus replication. AIDS 4:21, 1990
3. Kornbluth RS, Oh PS, Munis JR, Cleveland PH, Richman DD: Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J Exp Med 169:1137, 1989
4. Koyanagi Y, O'Brien WA, Zhao JQ, Golde DW, Gasson JC, Chen IS: Cytokines alter production of HIV-1 from primary mononuclear phagocytes. Science 241:1673, 1988
5. Than S, Hu R, Oyaizu N, Romana J, Wang X, Sheikh S, Pawha S: Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children. J Infect Dis 175:47, 1997
6. Hyjek E, Lischner HW, Hyslop T, Bartkowiak J, Kubin M, Trinchieri G, Kozbor D: Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J Immunol 155:4060, 1995
7. Rollins BJ: Chemokines. Blood 90:909, 1997 (review)
8. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667, 1996
9. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J: The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135, 1996
10. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA: CC CKR5: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955, 1996
11. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Colllman RG, Doms RW: A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149, 1996
12. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR: Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661, 1996
13. Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kuntsman K, Erickson D, Dragon E, Landau NR, Phair J, Ho DD, Koup RA: The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 2:1240, 1996
14. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1alpha, and MIP-1beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811, 1995
15. Vicenzi E, Biswas P, Mengozzi M, Poli G: Role of proinflammatory cytokines and beta-chemokines in controlling HIV replication. J Leukoc Biol 62:34, 1997
16. Hassan NF, Cutilli JR, Douglas SD: Isolation of highly purified human blood monocytes for in vitro HIV-1 infection studies of monocytes/macrophages. J Immunol Methods 130:283, 1990
17. Griffin DE, McArthur JC, Cornblath DR: Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic disease. Neurology 41:69, 1991
18. Emilie D, Peuchmaur M, Maillot MC, Crevon MC, Brousse N, Delfraissy JF, Dormont J, Galanaud P: Production of interleukins in human immunodeficiency virus-1 replicating lymph nodes. J Clin Invest 86:148, 1990
19. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, Fauci AS: Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 88:9838, 1991
20. Heagy W, Groopman J, Schindler J, Finberg R: Use of IFN-gamma in patients with AIDS. AIDS 3:584, 1990
21. Ganser A, Brucher W, Brodt HR, Busch W, Brandhorst I, Helm EB, Hoelzer D: Treatment of AIDS-related Kaposi's sarcoma with recombinant gamma-interferon. Onkologie 9:163, 1986
22. Dhawan W, Heredia A, Wahl LM, Epstein JS, Meltzer MS, Hewlett IK: Interferon-γ-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes. Pathobiology 63:93, 1995
23. Kozak SL, Platt EJ, Madani N, Ferro FE Jr, Peden K, Kabat D: CD4, CXCR-4 and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type-1. J Virol 71:873, 1997
24. Di Marzio P, Tse J, Landau NR: Chemokine receptor regulation and HIV type 1 tropism in monocytes-macrophages. AIDS Res Hum Retroviruses 14:129, 1998
25. Zella D, Barabitskaja O, Burns JM, Romerio F, Dunn DE, Revello MG, Gerna G, Reitz MS Jr., Gallo RC, Weichold FF: Interferon-γ increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cell lines. Blood 91:4444, 1993
26. Penton-Rol G, Polentarutti N, Luini W, Borsatti A, Mancinelli R, Sica A, Sozzani S, Mantovani A: Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by TFN-γ. J Immunol 160:3869, 1998
27. Wilson CB, Westall J, Johnston L, Lewis DB, Dower SK, Alpert AR: Decreased production of interferon-gamma by human neonatal cells - Intrinsic and regulatory deficiencies. J Clin Invest 77:860, 1986
28. Ho WZ, Lioy J, Song L, Cutilli JR, Polin RA, Douglas SD: Infection of cord blood monocyte-derived macrophages with human immunodeficiency virus type 1. J Virol 66:573, 1992
29. Fear WR, Kesson AM, Naif H, Lynch GW, Cunningham AL: Differential tropism and chemokine receptor expression of human immunodeficiency virus type 1 in neonatal monocytes, monocytederived macrophages, and placental macrophages. J Virol 72:1334, 1998
30. Marodi L, Kaposzta R, Campbell DE, Polin RA, Csongor J, Johnston RB: Candidacidal mechanisms in the human neonate. Impaired IFN-γ activation of macrophages in newborn infants. J Immunol 153:5643, 1994
31. Mark DG, Yue X, Gray SM: Cord blood CD4+ T lymphocytes differentially express CCR5 and CXCR4 HIV-1 coreceptors. Pediatr Res 43:240A, 1998 (abstr)
32. Rich EA, Chen IS, Zack JA, Leonard ML, O'Brien WA: Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1, J Clin Invest 89:176, 1992
33. Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F: Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation. J Leukoc Biol 62:49, 1997
34. Sica A, Saccani A, Borsatti A, Power CA, Wells TNC, Luini W, Polentarutti N, Sozzani S, Mantovani A: Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J Exp Med 185:969, 1997
35. Verani A, Scarlatti G, Comar M, Tresoldi E, Polo S, Giacca M, Lusso P, Siccardi AG, Vercilli D: C-C chemokines released by lipopolysaccharide (LPS)-stimulated human macrophages suppress HIV-1 infection in both macrophages and T cells. J Exp Med 185:805, 1997