Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitary-adrenal secretory activity in humans

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 9, 1999, Pages 3041-3046

  Fruehwald Schultes, Bernd ^a   Kern, Werner ^a   Bong, Wolfgang ^a   Wellhoener, Peter ^a   Kerner, Wolfgang ^b   Born, Jan ^a   Fehm, Horst L ^a   Peters, Achim ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b Klinikum Karlsburg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOSE; HYDROCORTISONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0033304939     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.9.5953     Document Type: Article

References (41)

1. Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients
2. Hypothalamic-pituitary-adrenocortical activity in patients with diabetes mellitus
3. Adrenal steroid and adrenocorticotropin responses to human corticotropin-releasing hormone stimulation test in adolescents with type I diabetes mellitus
4. Increased urinary-free cortisol outputs in diabetic patients
5. Low-dose ovine corticotropin-releasing hormone stimulation test in diabetes mellitus with or without neuropathy
6. The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: Suggestion of mild chronic hypercortisolism
7. Abnormal results of dexamethasone suppression tests in nondepressed patients with diabetes mellitus [published erratum appears in Arch Gen Psychiatry 1987 Jun; 44(6):517]
8. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution
9. Cortisol secretion in relation to body fat distribution in obese premenopausal women
10. Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in women with visceral and subcutaneous obesity: Effects of the corticotropin-releasing factor/arginine-vasopressin test and of stress
11. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: A dose-response study
12. Control of blood sugar in insulin-dependent diabetes: Comparison of an artificial endocrine pancreas, continuous subcutaneous insulin infusion, and intensified conventional insulin therapy
13. Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance
14. Body fat distribution, insulin resistance, and metabolic diseases
15. Non-insulin-dependent diabetes mellitus secondary to other endocrine disorders
16. Mechanisms of insulin resistance in human obesity
17. Receptor and postreceptor defects contribute to the insulin resistance in non-insulin-dependent diabetes mellitus
18. Dose-response relationships between plasma adrenocorticotropin (ACTH), cortisol, aldosterone, and 18-hydroxycorticosterone after injection of ACTH-(1-39) or human corticotropin-releasing hormone in man
19. Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs
20. Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans
21. Autonomic and hemodynamic responses to insulin in lean and obese humans
22. Neuroendocrine responses to starvation and weight loss
23. Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men
24. Importance of insulin in subjective, cognitive, hormonal responses to hypoglycemia in patients with IDDM
25. Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans
26. Suppression of counterregulatory hormone response to hypoglycemia by insulin per se
27. Physiologic hyperinsulinemia enhances counterregulatory hormone responses to hyperglycemia in IDDM
28. The effect of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans
29. Evidence that the brain of the conscious dog is insulin sensitive
30. Protective effect of insulin against hypoglycemia-associated counterregulatory failure
31. Physiologic action of insulin
32. Diurnal cortisol peaks and their relationships to meals
33. Nycthemeral rhythm in adrenal responsiveness to ACTH
34. Reset of feedback in the adrenocortical system: An apparent shift in sensitivity of adrenocorticotropin to inhibition by corticosterone between morning and evening
35. Insulin in the brain: A hormonal regulator of energy balance
36. Insulin inhibits pyramidal neurons in hippocampal slices
37. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis
38. Hyperinsulinemia suppresses glucose utilization in specific brain regions: In vivo studies using the euglycemic clamp in the rat
39. Insulin receptors in the pituitary gland: Morphological evidence for influence on opioid peptide-synthesizing cells
40. Characterization of insulin-like growth factor I and insulin receptors on cultured bovine adrenal fasciculata cells. Role of these peptides on adrenal cell function
41. Does central obesity reflect 'Cushing's disease of the omentum'?