Insulin receptors in the pituitary gland: Morphological evidence for influence on opioid peptide-synthesizing cells

Cell and Tissue Research

Volumn 288, Issue 3, 1997, Pages 471-483

  Unger, Jürgen W ^a   Lange, Winfried ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Beta endorphin; Immunocytochemistry; Insulin receptor; Insulin like growth factor 1 receptor; Phosphotyrosine; Pituitary; Rat (Sprague Dawley)

Indexed keywords

BETA ENDORPHIN; FOLLITROPIN; INSULIN RECEPTOR; PHOSPHOTYROSINE; SOMATOMEDIN C RECEPTOR;

ADENOHYPOPHYSIS; ANIMAL TISSUE; ARTICLE; ELECTRON MICROSCOPY; ENDOCRINE CELL; IMMUNOCYTOCHEMISTRY; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SECRETORY CELL;

ANIMALS; BETA-ENDORPHIN; CELL NUCLEUS; CYTOPLASMIC GRANULES; ENERGY METABOLISM; FEEDING BEHAVIOR; HOMEOSTASIS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, IMMUNOELECTRON; MITOCHONDRIA; MODELS, BIOLOGICAL; PHOSPHOTYROSINE; PITUITARY GLAND; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN;

ANIMALIA;

EID: 0030915928     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050833     Document Type: Article

References (69)

1. Ang LC, Bhaumick B, Munoz DG, Sass J, Juurlink HJ (1992) Effects of astrocytes, insulin and insulin-like growth factor I on the survival of motoneurons in vitro. J Neurol Sci 109:168-172
2. Bancroft FC (1981) Functional cell lines of rat pituitary tumor cells. In: Sato G (ed) Functionally differentiated cell lines. Liss, New York, pp 47-59
3. Baskin DG, Figlewicz DP, Woods SC, Porte D Jr, Dorsa DM (1987) Insulin in the brain. Annu Rev Physiol 49:335-347
4. Baskin DG, Sipols AJ, Schwartz MW, White MF (1993) Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine. Regul Pept 48:257-266
5. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL (1981) Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 212:1279-1281
6. Blasquez C, Jégou S, Friard O, Tonon MC, Fournier A, Vaudry H (1995) Effect of centrally administered neuropeptide Y on hypothalamic and hypophyseal proopiomelanocortin-derived peptides in the rat. Neuroscience 68:221-227
7. Bloom F, Battenberg ELF, Rossier J, Ling N, Leppaluotu J, Vargo TM, Guillemin R (1977) Endorphins are located in the intermediate and anterior lobes of the pituitary gland, not in the neurohypophysis. Life Sci 20:43-48
8. Bohannon NJ, Corp ES, Wilcox BJ, Figlewicz DP, Dorsa DM, Baskin DG (1988) Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography. Brain Res 444:205-213
9. Bondy CA, Lee W-H (1993) Patterns of insulin-like growth factor and IGF receptor gene expression in the brain: functional implications. Ann NY Acad Sci 692:33-43
10. Cusin I, Dryden S, Wang Q, Rohner-Jeanrenaud F, Jeanrenaud B, Williams G (1995) Effects of sustained physiological hyperinsulinemia on hypothalamic neuropeptide Y and NPY mRNA levels in the rat. Neuroendocrinology 7:193-197
11. Dalayeun JF, Norès JM, Bergal S (1993) Physiology of β-endorphins. A close-up view and a review of the literature. Biomed Pharmacother 47:311-320
12. De Keyser J, Wilczak N, De Backer J-P, Herroelen L, Vauquelin G (1994) Insulin-like growth factor-I receptors in human brain and pituitary gland: an autoradiographic study. Synapse 17: 196-202
13. D'Ercole AJ, Stiles AD, Underwood LE (1984) Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine and autocrine mechanisms of action. Proc Natl Acad Sci USA 81:935-939
14. Girault JA, Chamak B, Bertuzzi G, Tixier H, Wang JKT, Pang DT, Greengard P (1992) Protein phosphotyrosine in mouse brain - developmental changes and regulation by epidermal growth factor, type-I insulin-like growth factor, and insulin. J Neurochem 58:518-528
15. Giugliano D, Lefebvre PJ (1991) A role for β-endorphin in the pathogenesis of human obesity? Horm Metab Res 6:251-256
16. Giugliano D, Cozzolino D, Ceriello A, Salvatore T, Paolisso G, Torella R (1989) Beta-endorphin and islet hormone release in humans: evidence for interference with cAMP. Am J Physiol 257:E361-E366
17. Goldstein BJ, Dudley AL (1990) The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing. Mol Endocrinol 2:235-244
18. Grossman SP (1986) The role of glucose, insulin and glucagon in the regulation of food intake and body weight. Neurosci Behav Rev 10:295-315
19. Ipp E, Dobbs R, Unger RH (1978) Morphine and β-endorphin influence the secretion of endocrine pancreas. Nature 276:190-191
20. Johnson RD (1995) Opioid involvment in feeding behaviour and the pathogenesis of certain eating disorders. Med Hypothes 45:491-497
21. Kalra PS, Dube MG, Sahu A, Phelps CP, Kalra SP (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 88:10931-10935
22. Kanematsu T, Irahara M, Miyake T, Shitsukawa K, Aono T (1991) Effect of insulin-like growth factor-I on gonadotropin release from the hypothalamus-pituitary axis in vitro. Acta Endocrinol 125:227-233
23. Kononen J, Soinila S, Persson H, Honkaniemi J, Höfelt T, Pelto-Huikko M (1994) Neurotrophins and their receptors in the rat pituitary gland: regulation of BDNF and trkB mRNA levels by adrenal hormones. Mol Brain Res 27:347-354
24. Kotz CM, Grace MK, Briggs J, Levine AS, Billington CJ (1995) Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. J Clin Invest 96:163-170
25. Leibowitz SF (1992) Neurochemical-neuroendocrine systems in the brain controlling macronutrient intake and metabolism. Trends Neurosci 15:491-497
26. Leibowitz SF, Weiss GF, Shor-Posner G (1987) Medial hypothalamic serotonin in the control of eating behavior. Int J Obes Suppl 3:109-123
27. Lesniak MA, Hill JA, Kiess W, Rojeski M, Pert CB, Roth J (1988) Receptors for IGF-I and -II: autoradiographic localization in the rat brain and comparison to receptors for insulin. Endocrinology 123:2089-2099
28. Levine AS, Morley JE, Gosnell BA, Billington CJ, Bartness TJ (1985) Opioids and consummatory behaviour. Brain Res Bull 14:663-672
29. Livingston JN, Unger JW (1992) Immunohistochemical localization and biochemical analysis of tyrosine kinases in the central nervous system. Neuroprotocols 1:193-200
30. Margules DL, Moisset B, Lewis MJ, Shibuya H, Pert CB (1978) Beta-endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). Science 202:988-991
31. McCaleb ML, Myers RD (1982) 2-Deoxy-D-glucose and insulin modify release of norepinephrine from rat hypothalamus. Am J Physiol 242:R596-R60l
32. McElduff A, Poronnik P, Baxter RC, Williams P (1988) A comparison of the insulin and insulin-like growth factor I receptors from rat brain and liver. Endocrinology 122:1933-1939
33. McKibbin PE, McCarthy HD, Shaw P, Williams G (1992) Insulin deficiency is a specific stimulus to hypothalamic neuropeptide Y: a comparison of the effects of insulin replacement and food restriction in streptozocin-diabetic rats. Peptides 13:721-727
34. McLaughlin CL, Baile CA, Della-Fera MA (1985) Meal-stimulated increased concentrations of beta-endorphin in the hypothalamus of Zucker obese and lean rals. Physiol Behav 35:891-896
35. Michels KM, Lee WH, Seltzer A, Saavedra JM, Bondy CA (1993) Up-regulation of pituitary [1251]insulin-like growth factor-I (1GF-I) binding and IGF binding protein-2 and IGF-I gene expression by estrogen. Endocrinology 132:23-29
36. Missale C, Boroni F, Sigala S, Buriani A, Fabris M, Leon A, Dal Toso R, Spano PF (1996) Nerve growth factor in the anterior pituitary: localization in mammotroph cells and cosecretion with prolactin by a dopamine-regulated mechanism. Proc Natl Acad Sci USA 93:4240-4245
37. Moss AM, Unger JW, Moxley III RT, Livingston JN (1990) Location of phosphotyrosine containing proteins in the rat forebrain corresponds to the distribution of the insulin receptor. Proc Natl Acad Sci USA 87:4453-4457
38. Nitsch C, Riesenberg R (1988) Immunocytochemical demonstration of GABAergic synaptic connections in rat substantia nigra after different lesions of the strionigral projection. Brain Res 461:127-142
39. Noguchi T, Sugisaki T, Kanamatsu T, Nishikawa N (1989) Presence of an insulin-like growth factor I (somatomedin C) immunoreactive substance in GH producing cells in the bovine anterior pituitary. Horm Metab Res 12:165-167
40. Ramabadran K, Bansinath M (1990) Glucose homeostasis and endogenous opioid peptides. Int J Clin Pharamacol Ther Toxicol 28:89-98
41. Rosenfeld RG, Ceda G, Wilson DM, Dollar LA, Hoffmann AR (1984) Characterization of high affinity receptors for insulin-like growth factors I and II on rat anterior pituitary cells. Endocrinology 114:1571-1575
42. Rossier J, Pittman Q, Bloom F, Guillemin R (1980) Distribution of opioid peptides in the pituitary: a new hypothalamic-pars nervosa enkephalinergic pathway. Fed Proc 39:2555-2560
43. Sandberg A-C, Engberg C, Lake M, Holst H von, Sara VR (1988) The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma. Neurosci Lett 93:114-119
44. Sara VR, Hall K, Von Holtz H, Humbel R, Sjögren B, Wetterberg L (1982) Evidence for the presence of specific receptors for insulin-like growth factors I (IGF-1) and 2 (1GF-2) and insulin throughout the adult human brain. Neurosci Lett 34:39-44
45. Sauter A, Goldstein M, Engel J, Ueta K (1983) Effect of insulin on central catecholamines. Brain Res 260:330-333
46. Schick RR, Schusdziarra V, Nussbaumer C, Classen M (1991) Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain Res 552:232-239
47. Schick RR, Samsami S, Zimmermann JP, Eberl T, Endres C, Schusdziarra V, Classen M (1993) Effect of galanin on food intake in rats: involvement of lateral and ventromedial hypothalamic sites. Am J Physiol 264:R355-R361
48. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr (1992a) Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 13:387-414
49. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP, Porte D Jr (1992b) Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608-3616
50. Shia MA, Pilch PF (1983) The β-subunit of the insulin receptor is an insulin-activated protein-kinase. Biochemistry 22:717-721
51. Soldani R, Cagnacci A, Yen SS (1994) Insulin, insulin-like growth factor I (IGF-I) and IGF-II enhance basal and gonadotrophin-releasing hormone-stimulated luteinizing hormone release from rat anterior pituitary cells in vitro. Fur J Endocrinol 131:641-645
52. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-1192
53. Stanley BG, Magdalin W, Seirafi A, Nguyen MM, Leibowitz SF (1992) Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 13:581-587
54. Sternberger LA (1979) Immunocytochemistry, 2nd edn. Wiley, New York
55. Sun AJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White ME (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77
56. Turyn D, Dellacha JM (1980) Insulin binding sites in rat hypophysis. Int Res Commun Syst Med Sci Libr Compend 8:580-581
57. Ullrich A, Bell JR, Chen E, Herrera R, Petruzzelli LM, Dull TJ, Gray A, Coussens L, Liao Y-C, Tsubokawa M, Mason A, Secburg PH, Greenfeld C, Rosen OM, Ramachandran J (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756-761
58. Ullrich A, Gray A, Tam AW, Yang-Zeng T, Tsubokawa M, Collina C, Henzel W, LeBon T, Kathuria S, Chen E, Jacobs S, Frabcke U, Ramachandran J, Fujita-Yamaguchi Y (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinates that define functional specificity. EMBO J 5:2503-2512
59. Unger J, McNeill TH, Moxley III RT, White M, Moss AM, Livingston JN (1989) Distribution of insulin receptor-like immunoreactivity in the rat forebrain. Neuroscience 31:143-157
60. Unger JW, Livingston JN, Moss AM (1991) Insulin receptors in the central nervous system: localizalion, signalling mechanisms and functional aspects. Prog Neurobiol 36:343-362
61. Unger JW, Moss AM, Livingston JN (1993) The pars tuberalis is enriched with distinct phosphotyrosine-containing proteins not detected in other areas of the brain and pituitary. Cell Tissue Res 272:499-507
62. Werner H, Roberts CT Jr, Raizada MK, Bondy CA, Adamo M, LeRoith D (1993) Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system. In: Zagon JS, McLaughlin PJ (eds) Receptors in the developing nervous system, vol 1. Growth factors and hormones. Chapman & Hall, London, pp 109-127
63. Werther GA, Hogg A, Oldfield BJ, McKinley MJ, Figdor R, Allen AM, Mendelsohn FAO (1987) Localization and characterization of insulin receptors in the rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 121:1562-1570
64. Werther GA, Hogg A, Oldfield BJ, McKinley MJ, Figdor R, Mendelsohn FAO (1989) Localization and characterization of IGF-I receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry: a distinct distribution from insulin receptors. J Neuroendocrinol 1:369-377
65. Williams G, Jaswinder SG, Lee YC, Cardoso HM, Okpere BE, Bloom SR (1989) Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats. Diabetes 38:321-327
66. Whitley NC, Barb CR, Utley RV, Popvell JM, Kraeling RR, Rampacek GB (1995) Influence of stage of the estrous cycle on insulin-like growth factor-I modulation of luteinizing hormone secretion in the gilt. Biol Reprod 53:1359-1364
67. Woods SC, Lotter EC, McKay LD, Porte D Jr (1979) Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282:503-505
68. Woods SC, Porte D Jr, Bobbioni E, Ionescu E, Sauter J-F, Rohner-Jeanrenaud F, Jeanrenaud B (1985) Insulin: its relationship to the central nervous system and control of food intake and body weight. Am J Clin Nutr 42:1063-1071
69. Yamashita S, Melmed S (1986) IGF-I action on rat anterior pituitary cells: suppression of growth hormone secretion and mRNA levels. Endocrinology 118:176-182