Autoxidation of amyloid precursor protein and formation of reactive oxygen species

Advances in Experimental Medicine and Biology

Volumn 448, Issue , 1999, Pages 183-192

  Multhaup, G ^a   Hesse, L ^a   Borchardt, T ^a   Ruppert, Thomas ^b   Cappai, R ^c,d   Masters, C L ^c,d   Beyreuther, K ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; REACTIVE OXYGEN METABOLITE;

AUTOOXIDATION; CONFERENCE PAPER; METAL BINDING; NERVE CELL DEGENERATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

EID: 0033278328     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4859-1_16     Document Type: Conference Paper

References (51)

1. Beem, K. M., Rich, W. E., and Rajagopalan, K. V. (1974). Total reconstitution of copper-zinc superoxide dismutase. J. Biol. Chem. 249, 7298-7305.
2. Beher, D., Hesse, L., Masters, C. L., and Multhaup, G. (1996). Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem 271, 1613-1620.
3. Beyreuther, K., Multhaup, G., and Masters, C. L. (1996). Alzheimer's disease: genesis of amyloid. Ciba Found Symp 199, 119-27; discussion 127-31
4. Breen, K. C. (1992). APP-collagen interaction is mediated by a heparin bridge mechanism. Mol. Chem. Neuropathol. 16, 109-121.
5. Brown, R. H., Jr. (1995). Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 80, 687-92.
6. Bush, A. I., Multhaup, G., Moir, R. D., Williamson, T. G., Small, D. H., Rumble, B., Pollwein, P., Beyreuther, K., and Masters, C. L. (1993). A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. J. Biol. Chem. 268, 16109-16112.
7. Bush, A. I., Pettingell, W. H., Multhaup, G., d Paradis, M., Vonsattel, J. P., Gusella, J. F., Beyreuther, K., Masters, C. L., and Tanzi, R. E. (1994). Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265, 1464-7.
8. Camakaris, J., Petris, M. J., Bailey, L., Shen, P. Y., Lockhart, P., Glover, T. W., Barcroft, C. L., Patton, J., and Mercer, J. F. B. (1995). Gene amplification of the Menkes (Mnk ATP7a) P Type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux. Hum. Mol. Genet. 4, 2117-2123.
9. Cork, L. C., Masters, C., Beyreuther, K., and Price, D. L. (1990). Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. Am J Pathol 137, 1383-92.
10. Culotta, V. C., Klomp, L. W., Strain, J., Casareno, R. L., Krems, B., and Gitlin, J. D. (1997). The copper chaperone for superoxide dismutase. J Biol Chem 272, 23469-72.
11. Giaccone, G., Tagliavini, F., Linoli, G., Bouras, C., Frigerio, L., Frangione, B., and Bugiani, O. (1989). Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques. Neurosci Lett 97, 232-8.
12. Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H. X., Chen, W., Zhai, P., Sufit, R. L., and Siddique, T. (1994). Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-5.
13. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992). Amyloid beta-peptide is produced by cultured cells during normal metabolism ·. Nature 359, 322-5.
14. Harris, E. D. (1991). Copper transport: an overview. Proc. Soc. Exp. Biol. Med. 196, 130-40.
15. Hesse, L., Beher, D., Masters, C. L., and Multhaup, G. (1994). The beta A4 amyloid precursor protein binding to copper. FEBS. Lett. 349, 109-116.
16. Hodgson, E. K., and Fridovich, I. (1975). The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. Biochemistry 14, 5294-9.
17. Hottinger, A. F., Fine, E. G., Gurney, M. E., Zurn, A. D., and Aebischer, P. (1997). The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis. Eur J Neurosci 9, 1548-51.
18. Hung, I. H., Suzuki, M., Yamaguchi, Y., Yuan, D. S., Klausner, R. D., and Gitlin, J. D. (1997). Biochemical characterization of the wilson disease protein and functional expression in the yeast saccharomyces cerevisiae. J. Biol. Chem. 272, 21461-2146.
19. Komiyama, Y., Murakami, T., Egawa, H., Okubo, S., Yasunaga, K., and Murata, K. (1992). Purification of factor XIa inhibitor from human platelets. Thromb Res 66, 397-408.
20. Koo, E. H., and Squazzo, S. L. (1994). Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J. Biol. Chem. 269, 17386-17389.
21. Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., and Strickland, D. K. (1995). LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82, 331-340.
22. Li, Q. X., Evin, G., Small, D. H., Multhaup, G., Beyreuther, K., and Masters, C. L. (1995). Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets. J. Biol. Chem. 270, 14140-14147.
23. Linder, M. C., and Hazegh Azam, M. (1996). Copper biochemistry and molecular biology. Am. J. Clin. Nutr. 63, 797s-811s.
24. Milward, E. A., Papadopoulos, R., Fuller, S. J., Moir, R. D., Small, D., Beyreuther, K., and Masters, C. L. (1992). The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9, 129-137.
25. Miyata, M., and Smith, J. D. (1996). Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat. Genet. 14, 55-61.
26. Multhaup, G. (1994). Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans. Biochimie 76, 304-311.
27. Multhaup, G., Bush, A. I., Pollwein, P., and Masters, C. L. (1994). Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP). FEBS Lett 355, 151-154.
28. Multhaup, G., Ruppert, T., Schlicksupp, A., Hesse, L., Beher, D., Masters, C. L., and Beyreuther, K. (1997). Reactive oxygen species and Alzheimer's disease. Biochem Pharmacol 54, 533-9.
29. Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., and Beyreuther, K. (1996). The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I). Science 271, 1406-1409.
30. Narindrasorasak, S., Lowery, D. E., Altman, R. A., Gonzalez DeWhitt, P. A., Greenberg, B. D., and Kisilevsky, R. (1992). Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins. Lab. Invest. 67, 643-652.
31. Ooi, C. E., Rabinovich, E., Dancis, A., Bonifacino, J. S., and Klausner, R. D. (1996). Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis. EMBO J 15, 3515-3523.
32. Percival, S. S., and Harris, E. D. (1989). Ascorbate enhances copper transport from ceruloplasmin into human K562 cells. J. Nutr. 119, 779-784.
33. Pufahl, R. A., Singer, C. P., Peariso, K. L., Lin, S., Schmidt, P. J., Fahrni, C. J., Culotta, V. C., Penner-Hahn, J. E., and O'Halloran, T. V. (1997). Metal ion chaperone function of the soluble Cu(I) receptor atx1. Science 278, 853-6.
34. Roch, J. M., Shapiro, I. P., Sundsmo, M. P., Otero, D. A., Refolo, L. M., Robakis, N. K., and Saitoh, T. (1992). Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor. J. Biol. Chem. 267, 2214-2221.
35. Saitoh, T., Sundsmo, M., Roch, J. M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., and Schenk, D. B. (1989). Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 58, 615-622.
36. Sato, K., Akaike, T., Kohno, M., Ando, M., and Maeda, H. (1992). Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme. J Biol Chem 267, 25371-7.
37. Selkoe, D. J. (1996). Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271, 18295-18298.
38. Shivers, B. D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K., and Seeburg, P. H. (1988). Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. Embo J 7, 1365-70.
39. Simons, M., Ikonen, E., Tienari, P. J., Cidarregui, A., Monning, U., Beyreuther, K., and Dotti, C. G. (1995). Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites. J. Neurosci. Res. 41, 121-128.
40. Sisodia, S. S., Koo, E. H., Beyreuther, K., Unterbeck, A., and Price, D. L. (1990). Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-495.
41. Small, D. H., Nurcombe, V., Reed, G., Clarris, H., Moir, R., Beyreuther, K., and Masters, C. L. (1994). A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J. Neurosci. 14, 2117-2127.
42. Stewart, L. C., and Klinman, J. P. (1988). Dopamine beta-hydroxylase of adrenal chromaffin granules: structure and function. Annu. Rev. Biochem. 57, 551-592.
43. Van Nostrand, W. E. (1995). Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid beta-protein precursor. Thromb Res 78, 43-53.
44. Wang, D., and Munoz, D. G. (1995). Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer's disease and normal aged brain. J Neuropathol Exp Neurol 54, 548-556.
45. Whyte, S., Jones, L., Coulson, E. J., Moir, R. D., Bush, A. I., Beyreuther, K., and Masters, C. L. (1997). The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc. In Alzheimer's Disease: Biology, Diagnosis and Therapeutics, K. Iqbal, B. Winblad, T. Nishimura, M. Takeda and H. M. Wisniewski, eds. (Chichester: John Wiley & Sons Ltd), pp. 417-422.
46. Wiedau-Pazos, M., Goto, J. J., Rabizadeh, S., Gralla, E. B., Roe, J. A., Lee, M. K., Valentine, J. S., and Bredesen, D. E. (1996). Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 271, 515-518.
47. Wong, P. C., Pardo, C. A., Borchelt, D. R., Lee, M. K., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., Cleveland, D. W., and Price, D. L. (1995). An adverse property of a familial ALS-linked Cu/Zn-SOD mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 1105-16.
48. Yamazaki, T., Selkoe, D. J., and Koo, E. H. (1995). Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J. Cell. Biol. 129, 431-442.
49. Yim, H. S., Kang, J. H., Chock, P. B., Stadtman, E. R., and Yim, M. B. (1997). A familial amyotrophic lateral sclerosis-associated A4V Cu,Zn-Superoxide dismutase mutant has a lower K-m for hydrogen peroxide. J Biol Chem 272, 8861-8863.
50. Yim, M. B., Kang, J. H., Yim, H. S., Kwak, H. S., Chock, P. B., and Stadtman, E. R. (1996). A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in K-m for hydrogen peroxide. Proc Natl Acad Sci USA 93, 5709-5714.
51. Zhou, B., and Gitschier, J. (1997). hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci U S A 94, 7481-6.