How cells use proteolysis to control their growth

Molecular Medicine

Volumn 5, Issue 12, 1999, Pages 773-782

  Tansey, W P ^a  

^a Watson School of Biological Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; PROTEASOME; UBIQUITIN;

CELL CYCLE; CELL DIVISION; CELL GROWTH; GROWTH REGULATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW;

EID: 0033276624     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401990     Document Type: Review

References (39)

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2. Expression of the Hs-Orc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
3. CDK inhibitors: Positive and negative regulators of G1-phase progression
4. The ubiquitin system
5. The proteasome, a novel protease regulated by multiple mechanisms
6. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
7. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
8. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
9. Whose end is destruction: Cell division and the anaphase-promoting complex
10. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
11. SCF and APC: The yin and yang of cell cycle regulated proteolysis
12. Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins
13. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
14. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase
15. Cyclin is degraded by the ubiquitin pathway
16. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
17. Geminin, an inhibitor of DNA replication, is degraded during mitosis
18. Cdc25 cell-cycle phosphatase as a target of c-myc
19. The role of c-myc in cellular growth control
20. Control of c-myc regulation in normal and neoplastic cells
21. Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
22. Yeast G1 cyclins are unstable in G1 phase
23. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis
24. Stress-activated kinases regulate protein stability
25. Mdm2 promotes the rapid degradation of p53
26. DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells
27. Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Weel
28. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
29. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
30. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
31. The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex
32. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
33. Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway
34. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
35. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
36. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
37. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene
38. The cyclin-dependent kinase inhibitor p27(Kip1) induces N-terminal proteolytic cleavage of cyclin A
39. Giant Proteases: Beyond the proteasome