Coenzyme Q10 can in some circumstances block apoptosis, and this effect is mediated through mitochondria

Annals of the New York Academy of Sciences

Volumn 887, Issue , 1999, Pages 31-47

  Kagan, Terri ^a   Davis, Claudette ^a   Lin, Lin ^a   Zakeri, Zahra ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; UBIDECARENONE; ALCOHOL; CERAMIDE; CYCLOHEXIMIDE; DRUG DERIVATIVE; UBIQUINONE;

ANIMAL CELL; APOPTOSIS; CELL CULTURE; CELL SURVIVAL; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; RAT; ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL MEMBRANE POTENTIAL; CELL PROTECTION; CELL STRAIN; CELL STRAIN U937; DRUG EFFECT; INTRACELLULAR MEMBRANE; MITOCHONDRION; PHYSIOLOGY;

ANIMALIA;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CERAMIDES; CYCLOHEXIMIDE; CYTOPROTECTION; ETHANOL; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; PC12 CELLS; RATS; U937 CELLS; UBIQUINONE;

EID: 0033233389     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07920.x     Document Type: Conference Paper

References (56)

1. 1. Kruman, I., Q. Guo & M.P. Mattson. 1998. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J. Neurosci. Res. 51: 293-308.
2. 2. Ha, H.C., J.D. Yager, P.A. Woster & R.A. Casero Jr. 1998. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem. Biophys. Res. Commun. 244: 298-303.
3. 3. Hruszkewycz, A.M. & D.S. Bertold. 1990. The 8-hydroxyguanine content of isolated mitochondria increases with lipid peroxidation. Mutat. Res. 244: 123-128.
4. 4. Zhang, J.R. & A. Sevanian. 1991. Effect of vitamin E on arachidonic acid peroxidation and its binding to Chinese hamster V79 cell DNA. Biochim. Biophys. Acta 1085: 159-166.
5. 5. Park, J.W. & K.A. Floyd. 1992. Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA. Free Radic. Biol. Med. 12: 245-250.
6. 6. Jacotot, E., P. Constantini, E. Laboureau, N. Zamzami, S.A. Susin & G. Kroemer. 1999. Mitochondrial membrane permeabilization during the apoptotic process. Ann. N.Y. Acad. Sci. 887: 18-30. This volume.
7. 7. Zwizinski, C.W. & H.H. Schmid. 1992. Peroxidative damage to cardiac mitochondria identification and purification of modified adenine nucleolide translocase. Arch. Biochem. Biophys. 294: 178-183.
8. 10 in patients with ischemic heart disease. Int. J. Clin. Pharmacol. Ther. Toxicol. 28: 123-126.
9. 9. Topi, P.L., A. Davini, G. Squarcini. 1989. Efficiency of ubidecarenone in the treatment of patients with cardiac insufficiency. Minerva Cardiangiol. 37: 255-258.
10. 10 for cardiomyopathy [abstract]. Klin. Wochenschr. 66: 583.
11. 11. Folkers, K., P. Langsjoen, Y. Nara, K Muratsu, J. Komorowski, P.C. Richardson & T.H. Smith. 1988. Biochemical deficiencies of Coenzyme Q10 in HIV-infection and exploratory treatment. Biochem. Biophys. Res. Commun. 153: 888-896.
12. 12. Densnuelle, J., F. Pellissier, G. Serratrice, J. Pouget & D.M. Turnbull. 1989. Kearns-Sayer syndrome: mitochondrial encephalomyopathy caused by deficiency of the respiratory chain. Rev. Neurol. (Paris). 145: 842-850.
13. 10 on dibenzpyrene-induced tumors and infection with friend leukemia virus in mice. Proc. Natl. Acad. Sci. USA 70: 390-394.
14. 10. Biochem. Biophys. Res. Commun. 192: 241-245.
15. 10 concentrations in breast cancer: prognosis and therapeutic consequences. Int. J. Clin. Pharmacol. Ther. 36: 506-509.
16. 16. Rawn, D.J. 1989. Oxidative Phosphorylation. Biochemistry. Neil Patterson Publishers, Burlington, NC.
17. 17. Mitchell, P. 1975. Proton-motive redox mechanism of the cytochrome b-c1 complex in the respiratory chain: proton-motive ubiquinone cycle. FEBS Lett. 56: 1-6.
18. 18. Schulze-Osthoff K., A.C. Bakker, B. Vanhaesebroeck, J. Beyaert, W.A. Jacob & W. Fiers 1992. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J. Biol. Chem. 267: 5317-5323.
19. 19. Forsmark-Andree, P. & L. Ernster. 1994. Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol. Aspects Med. 15(Suppl.): 73-81.
20. 20. Stocker, R., V.W. Bowry & B. Frei. 1991. Ubiquinol-10 protects human low-density lipoproteins more efficiently against lipid peroxidation than does α-tocopherol. Proc. Natl. Acad. Sci. USA 88: 1646-1650.
21. 10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim. Biophys. Acta 1126: 247-254.
22. 22. Frei, B., M.C. Kim & B.N. Ames. 1990. Ubiquinol-10 is an effective lipid-soluble antioxidanl at physiological concentrations. Proc. Natl. Acad. Sci. USA 87: 4879-4883.
23. 23. Ferrari, G., C.Y. Yan & L.A. Greene. 1995. N-acetylcysteine (D-and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci. 15: 2857-2866.
24. 24. Iimura, O., F. Vrtovsnik, F. Terzi & G. Friedlander. 1997. HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Kidney Int. 52: 962-972.
25. 25. Barroso, M.P., C. Gomez-Diaz, J.M. Villalba, M.I. Buron, G. Lopez-Lluch & P. Navas. 1997. Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. J. Bioenerg. Biomembr. 29: 259-267.
26. 26. Sun, I.L., E.E. Sun & F.L. Crane. 1992. Stimulation of serum-free cell proliferation by Coenzyme Q. Biochem. Biophys. Res. Commun. 189: 8-13.
27. 10-. plasma membrane oxidase and growth control. Mol. Aspects Med 15 (Suppl.): s1-s11.
28. 28. Camilleri-Broet, S., H. Vanderwerff, E. Caldwell & D. Hockenberry. 1998. Distinct alterations in mitochondrial mass and function characterize different models of apoptosis. Exp. Cell Res. 239: 277-292.
29. 29. Hannun, Y.A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science 274: 1855-1859.
30. 30. Haimovitz-Friedman, A., R.N. Kolesnick & Z. Fuks. 1997. Ceramide signaling in apoptosis. Br. Med. Bull. 53: 539-553.
31. 31. Hannun, A. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269: 3125-3128.
32. 32. Young, D.A. 1969. Glucocorticoid action on rat thymus cells. Interrelationships between carbohydrate, protein and adenine nucleotide metabolism and cortisol effects on these functions in vitro. J. Biol. Chem. 244: 2210-2217.
33. + T cells. J. Immunol. 162: 5287-5298.
34. 34. Miller, M.W. 1996. Mechanisms of ethanol induced neuronal death during development: from the molecule to behavior. Alcohol Clin. Exp. Res. 20 (Suppl. 8): 128A-132A.
35. 35. Kurose, I., H. Higuchi, S. Kato, S. Miura & H. Ishii. 1996. Ethanol induced oxidative stress in the liver. Alcohol Clin. Exp. Res. 20(Suppl. 1): 77A-85A.
36. 36. Batistatou, A. & L. Greene. 1991. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J. Cell Biol. 115: 461-471.
37. 37. Miyashita, T. & J.C. Reed. 1993. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81: 151-157.
38. 38. Kagan, T. & Z. Zakeri. 1998. Detection of apoptotic cells in the nervous system. Methods in Molecular Medicine. J. Harry & H.A. Tilson, Eds. 22: 105-123.
39. 39. Zakeri, Z., D. Quaglino & H.S. Ahuja. 1994. Apoptotic cell death in the mouse limb and its suppression in the hammertoe mutant. Dev. Biol. 165: 294-297.
40. + and mitochondrial membrane potential preceding cell death in hepatocytes. Nature 325: 78-81.
41. 41. Johnson, L.V., M.L. Walsh, B.J. Bockus & J.B. Chen. 1981. Monitoring of relative mitochondrial membrane potential I living cells by fluorescence microscopy. J. Cell Biol. 88: 526-535.
42. 42. Mossman, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63.
43. 43. Skulachev, V.P. 1996. Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell. FEBS Lett. 397: 7-10.
44. 44. Macouillard-Poulletier de Gann, M.A. Belaud-Rotureau, P. Voisin, N. Leducq, F. Belloc & P. Canioni. 1998. Flow cytometric analysis of mitochondrial activity in situ: application to acetylceramide induced mitochondrial swelling and apoptosis. Cytometry 33: 333-339.
45. 45. Pastorino, J.G., G. Simbula, K. Yamamoto, P.A. Glascott Jr., R.J. Rothman & J.L. Farber. 1996. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J Biol. Chem. 271: 29792-29798.
46. 46. Susin, S.A., N. Zamzami, & M. Castedo. 1997. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95-and ceramide-induced apoptosis. J. Exp. Med. 186: 25-37.
47. 47. Yang, J.C. & G.A. Cortopassi. 1998. dATP causes specific release of cytochrome c from mitochondria. Biochem Biophys Res Commun. 250: 454-457.
48. 48. Zamzami, N., S.A. Susin, P. Marcheti, T. Hirsch, I. Gomez-Monterrey, M. Castedo & G. Kroemer. 1996. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183: 1533-1544.
49. 49. Arora, A.S., B.J. Jones, T.C. Patel, S.F. Bronk & G.J. Gores. 1997. Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat. Hepatology. 25: 958-963.
50. 50. France-Lanord, V., B. Brugg, P.P. Michel, Y. Acid & M. Ruberg. 1997. Mitochondrial free radical signal in ceramide dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J. Neurochem. 69: 1612-1621.
51. 51. Quillet-Mary, A., J.P. Jaffrezou, V. Mansat, C. Bordier, J. Naval & G. Laurent. 1997. Implication of mitochondrial hydrogen peroxide generation in ceramide induced apoptosis. J. Biol Chem. 272: 21388-21395.
52. 52. Satoh, T., Y. Enokido, H. Aoshima, Y. Uchiyama & H. Hatanaku. 1997. Changes in mitochondrial membrane potential during oxidative stress induced apoptosis in PC12 cells. J. Neuro. Res. 50: 413-420.
53. 53. Balazs, R., O.S. Jorgensen & N. Hack. 1988. N-methyl D-aspartate promotes the survival of cerbellar granule cells in culture. Neuroscience 27: 437-451.
54. 54. Favit, A., F. Nicoletti, U. Scapagnini & P.L. Ceachico. 1992. Ubiquinone protects cultured neurons against spontaneous and excitotoxin induced degeneration. J. Cereb. Blood & Met. 12: 638-645.
55. 55. Xia, K., N.K. Mukhopadhyay, R.C. Inhorn, D.L. Barber, P.E. Rose, R.S. Lee, R.P. Narsimhan, A.D. D'Andrea, J.D. Griffin & T.M. Roberts. 1996. The cytokine activated tyrosine kinase JAK2 activates Raf1 in a p21ras dependent manner. Proc. Natl. Acad. Sci. USA 93: 11681-11686.
56. 56. Dobrowsky, R.T., M.H. Werner, A.M. Castellino, M.V. Chao & Y.A. Hannun. 1994. Activation of the sphingomyelin cycle through the low affinity neurotrophin receptor. Science 265: 1596-1599.