Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin

Journal of Immunology

Volumn 163, Issue 7, 1999, Pages 4033-4040

  Marguerat, Samuel ^a,c   MacDonald, H Robson ^a   Kraehenbuhl, Jean Pierre ^b   Van Meerwijk, Joost P M ^a,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; GAMMA IRRADIATION; HELPER CELL; HEMATOPOIETIC CELL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION; ULCERATIVE COLITIS;

ANIMALS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLITIS; DENDRITIC CELLS; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERFERON TYPE II; INTESTINAL MUCOSA; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RADIATION CHIMERA;

EID: 0033214528     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Mombaerts, P., E. Mizoguchi, M. J. Grusby, L. H. Glimcher, A. K. Bhan, and S. Tonegawa. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:274.
2. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
3. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
4. Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359:693.
5. + T cells. J. Exp. Med. 178:237.
6. + T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int. Immunol. 5:1461.
7. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179:589.
8. Podolsky, D. K. 1997. Lessons from genetic models of inflammatory bowel disease. Acta Gastroenterol. Belg. 60:163.
9. Kim, H. S., and A. Berstad. 1992. Experimental colitis in animal models. Scand. J. Gastroenterol. 27:529.
10. Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stuber, and W. Strober. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
11. Neurath, M. F., I. Fuss, B. L. Kelsall, D. H. Presky, W. Waegell, and W. Strober. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 183:2605.
12. + T cells. J. Exp. Med. 183:2669.
13. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
14. Nishimoto, H., H. Kikutani, K. Yamamura, and T. Kishimoto. 1987. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 328:432.
15. k transgenic mice. Nature 345:724.
16. Lund, T., L. O'Reilly, P. Hutchings, O. Kanagawa, E. Simpson, R. Gravely, P. Chandler, J. Dyson, J. K. Picard, A. Edwards, et al. 1990. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain. Nature 345:727.
17. d transgene on collagen-induced arthritis. J. Exp. Med. 180:1559.
18. Mustafa, M., C. Vingsbo, T. Olsson, S. Issazadeh, A. Ljungdahl, and R. Holmdahl. 1994. Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles. J. Immunol. 153:3337.
19. k α transgene in B10 mice suppresses the development of myasthenia gravis. Immunogenetics 31:241.
20. Merino, R., M. Iwamoto, L. Fossati, P. Muniesa, K. Araki, S. Takahashi, J. Huarte, K. Yamamura, J. D. Vassalli, and S. Izui. 1993. Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E α chain. J. Exp. Med. 178:1189.
21. Reich, E. P., R. S. Sherwin, O. Kanagawa, and C. A. Janeway, Jr. 1989. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature 341:326.
22. Schmidt, D., J. Verdaguer, N. Averill, and P. Santamaria. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. Med. 186:1059.
23. Slattery, R. M., J. F. Miller, W. R. Heath, and B. Charlton. 1993. Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes. Proc. Natl. Acad. Sci. USA 90:10808.
24. Bohme, J., B. Schuhbaur, O. Kanagawa, C. Benoist, and D. Mathis. 1990. MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science 249:293.
25. Luhder, F., J. Katz, C. Benoist, and D. Mathis. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J. Exp. Med. 187:379.
26. d transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc. Natl. Acad. Sci. USA 90:9566.
27. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
28. Deng, H., R. Apple, M. Clare-Salzler, S. Trembleau, D. Mathis, L. Adorini, and E. Sercarz. 1993. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 178:1675.
29. Mizoguchi, A., E. Mizoguchi, C. Chiba, G. M. Spiekermann, S. Tonegawa, C. Nagler-Anderson, and A. K. Bhan. 1996. Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease. J. Exp. Med. 183:847.
30. + T cells. Nature 369:654.
31. Duchmann, R., I. Kaiser, E. Hermann, W. Mayet, K. Ewe, and K. H. Meyer zum Buschenfelde. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102:448.
32. Duchmann, R., E. Schmitt, P. Knolle, K. H. Meyer zum Buschenfelde, and M. Neurath. 1996. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 26:934.
33. Contractor, N. V., H. Bassiri, T. Reya, A. Y. Park, D. C. Baumgart, M. A. Wasik, S. G. Emerson, and S. R. Carding. 1998. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. J. Immunol. 160:385.
34. Dianda, L., A. M. Hanby, N. A. Wright, A. Sebesteny, A. C. Hayday, and M. J. Owen. 1997. T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 150:91.
35. Mahler, M., I. J. Bristol, E. H. Leiter, A. E. Workman, E. H. Birkenmeier, C. O. Elson, and J. P. Sundberg. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 274:G544.
36. + -cell depleted, athymic and NK-cell depleted SCID mice. Inflamm. Res. 45:181.
37. Dieleman, L. A., B. U. Ridwan, G. S. Tennyson, K. W. Beagley, R. P. Bucy, and C. O. Elson. 1994. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107:1643.
38. Grusby, M. J., and L. H. Glimcher. 1995. Immune responses in MHC class II-deficient mice. Annu. Rev. Immunol. 13:417.
39. + T cells, but affect their long-term life span. Immunity 5:217.
40. Beutner, U., and H. R. MacDonald. 1998. TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host. Int. Immunol. 10:305.
41. Swain, S. L. 1983. T cell subsets and the recognition of MHC class. Immunol. Rev. 74:129.
42. + T cells. Science 248:1227.
43. Koentgen, F., G. Suess, C. Stewart, M. Steinmetz, and H. Bluethmann. 1993. Targeted disruption of the MHC class II Aα gene in C57BL/6 mice. Int. Immunol. 5:957.
44. van Meerwijk, J. P. M., E. M. O'Connell, and R. N. Germain. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J. Immunol. 154:6314.
45. Koo, G. C., and J. R. Peppard. 1984. Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma 3:301.
46. - variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis. J. Exp. Med. 153:595.
47. Dialynas, D. P., Z. S. Quan, K. A. Wall, A. Pierres, J. Quintans, M. R. Loken, M. Pierres, and F. W. Fitch. 1983. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131:2445.
48. Golstein, P., C. Goridis, A.-M. Schmitt-Verhulst, B. Hayot, A. Pierres, A. van Agthoven, Y. Kaufmann, Z. Eshhar, and M. Pierres. 1982. Lymphoid cell surface interaction structures detected using cytolysis-inhibiting monoclonal antibodies. Immunol. Rev. 68:5.
49. +) subsets among anti-Ia cytolytic T cell clones. J. Immunol. 132:2775.
50. Ledbetter, J. A., and L. A. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47:63.
51. Bhattacharya, A., M. E. Dorf, and T. A. Springer. 1981. A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J. Immunol. 127:2488.
52. Metlay, J. P., M. D. Witmer-Pack, R. Agger, M. T. Crowley, D. Lawless, and R. M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753.
53. Poussier, P., P. Edouard, C. Lee, M. Binnie, and M. Julius. 1992. Thymus-independent development and negative selection of T cells expressing T cell receptor αβ in the intestinal epithelium: evidence for distinct circulation patterns of gut-and thymus-derived T lymphocytes. J. Exp. Med. 176:187.
54. + T cells in an experimental model of colitis. Eur. J. Immunol. 27:17.
55. Prussin, C., and D. D. Metcalfe. 1995. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J. Immunol. Methods 188:117.
56. Maric, I., P. G. Holt, M. H. Perdue, and J. Bienenstock. 1996. Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine. J Immunol 156:1408.
57. + T cells. Immunity 1:553.
58. Novak, J. M., J. T. Collins, M. Donowitz, J. Farman, D. G. Sheahan, and H. M. Spiro. 1979. Effects of radiation on the human gastrointestinal tract. J. Clin. Gastroenterol. 1:9.
59. Mowat, A. M., and J. L. Viney. 1997. The anatomical basis of intestinal immunity. Immunol. Rev. 156:145.
60. Powrie, F. 1995. T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 3:171.
61. van Bekkum, D. W., O. Vos, and W. W. H. Weyzen. 1959. The pathogenesis of the secondary disease after foreign bone-marrow transplantation in X-irradiated mice. J. Natl. Cancer Inst. 23:75.
62. Kerneis, S., A. Bogdanova, J. P. Kraehenbuhl, and E. Pringault. 1997. Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277:949.
63. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
64. Croft, M., L. M. Bradley, and S. L. Swain. 1994. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 152:2675.
65. + T lymphocytes in class II-deficient mice. Proc. Natl. Acad. Sci. USA 90:2779.
66. van Meerwijk, J. P. M., S. Marguerat, R. K. Lees, R. N. Germain, B. J. Fowlkes, and H. R. MacDonald. 1997. Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185:377.
67. van Meerwijk, J. P.M., and H. R. MacDonald. 1999. In vivo T lymphocyte tolerance in the absence of thymic clonal deletion mediated by hematopoietic cells. Blood 93:3856.
68. Garside, P., and A. M. Mowat. 1997. Mechanisms of oral tolerance. Crit. Rev. Immunol. 17:119.
69. Weiner, H. L., A. Friedman, A. Miller, S. J. Khoury, A. al-Sabbagh, L. Santos, M. Sayegh, R. B. Nussenblatt, D. E. Trentham, and D. A. Hafler. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12:809.