5-aminosalicylic acid inhibits iNOS transcription in human intestinal epithelial cells

International Journal of Molecular Medicine

Volumn 4, Issue 4, 1999, Pages 437-443

  Kennedy, Michelle ^a,b   Wilson, Lori ^a,b   Szabö, Csaba ^a,b   Salzman, Andrew L ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b INOTEK CORPORATION   (United States)

Author keywords

5 ASA; Caco 2BBe; DLD 1; Enterocyte; Epithelium; Free radical; Inducible nitric oxide synthase; Inflammatory bowel disease; Intestinal mucosa; IRF 1; NF B; Nitric oxide

Indexed keywords

AMINOSALICYLIC ACID; CYTOKINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; MESSENGER RNA; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; INTERLEUKIN 1; MESALAZINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; NOS2A PROTEIN, HUMAN;

ARTICLE; CELL LINE; CONCENTRATION (PARAMETERS); DOSE RESPONSE; HUMAN; HUMAN CELL; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH MUCOSA INJURY; TRANSCRIPTION INITIATION; UPREGULATION; BIOSYNTHESIS; CELL STRAIN CACO 2; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; INTESTINE MUCOSA; METABOLISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CACO-2 CELLS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; INTESTINAL MUCOSA; MESALAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; TRANSCRIPTION, GENETIC;

EID: 0033210896     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.4.4.437     Document Type: Article

References (43)

1. Wahl C, Liptay S, Adler G and Schmid R: Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest 101: 1163-1174, 1998.
2. Crotty B, Hoang P, Dalton HR and Jewell DP: Salicylates used in inflammatory bowel disease and colchicine impair interferongamma induced HLA-DR expression. Gut 33: 59-64, 1991.
3. Miles AM and Grisham MB: Antioxidant properties of aminosalicylates. Methods Enzymol 234: 555-572, 1994.
4. Fox CC, Moore WC and Lichtenstein LM: Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. Dig Dis Sei 36: 179-184, 1991.
5. Crotty B, Rosenberg WMC, Aronson JK and Jewell DP: Inhibition of binding of interferon-gamma to its receptor by salicylates used in inflammatory bowel disease. Gut 33: 1353-1357, 1992.
6. Di Paolo MC, Merrett MN, Crotty B and Jewell DP: 5-Aminosalicylic acid inhibits the impaired epithelial barrier function induced by gamma interferon. Gut 38: 115-119, 1996.
7. Middleton SJ, Shorthouse M and Hunter JO: Increased nitric oxide synthesis in ulcerative colitis. Lancet 341: 465-466, 1993.
8. Guslandi M: Nitric oxide in ulcerative colitis. Lancet 341: 905-906, 1993.
9. Mourelle M, Casellas F, Guarner F and Malagelada J-R: Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon. Gastroenterology 109: 1497-1450, 1995.
10. MacDermott RP: Alterations of the mucosal immune system in inflammatory bowel disease. J Gastroenterol 31: 906-916, 1996.
11. Nakamura M, Saito H, Kasanuki J, Tamura Y and Yoshida S: Cytokine production in patients with inflammatory bowel disease. Gut 33: 933-937, 1992.
12. Boughton-Smith NK, Evans SM, Hawkey CJ, Cole AT, Balsitis M, Whittle BJ and Moncada S: Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 342: 338-340, 1993.
13. Rachmilewitz D, Stamler JS, Bachwich D, Karmeli F, Ackerman Z and Podolsky DK: Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. Gut 36: 718-723, 1995.
14. Salzman AL: Nitric oxide in the gut. New Horiz 3: 352-364, 1995.
15. Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE and Stenson WF: Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 111: 871-885, 1996.
16. Grisham MB, Specian RD and Zimmerman TE: Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis. J Pharmacol Exp Ther 271: 1114-1121, 1994.
17. Grisham MB and Yamada T: Neutrophils, nitrogen oxides, and inflammatory bowel disease. Ann NY Acad Sei 664: 103-115, 1992.
18. Salzman AL, Denenberg AG, Ueta I, O'Connor M, Linn S and Szabö C: Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers. Am J Physiol 270: G565-G573, 1996.
19. Salzman AL, Eaves-Pyles T, Linn S, Denenberg A and Szabö C: Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cells. Gastroenterology 114: 93-102, 1998.
20. Linn SC, Morelli PJ, Edry I, Cottongim SE, Szabö C and Salzman AL: Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line. Am J Physiol 272: G1499-G1508, 1997.
21. Miller MJ, Thompson JH, Zhang XJ, Sadowska-Krowicka H, Kakkis JL, Munshi UK, Sandoval M, Rossi JL, Eloby-Childress S, Beckman JS, Ye YZ, Rodi CP, Manning P, Currie M and Clark DA: Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109: 1475-1483, 1995.
22. Gardner PR, Costantino G, Szabö C and Salzman AL: Nitric oxide sensitivity of the aconitases. J Biol Chem 272: 25071-25076, 1997.
23. Kennedy MS, Denenberg A, Szabö C and Salzman AL: Poly (ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells. Gastroenterology 114: 510-518, 1998.
24. Peterson MD and Mooseker MS: An in vitro model for the analysis of intestinal brush border assembly. I. Ultrastructural analysis of cell contact-induced brush border assembly in Caco- 2BBe cells. J Cell Sei 102: 581-600, 1992.
25. Pflueger E, Mueller EA and Anderer FA: Preservation of cytotoxic function during multi-cycle immunomagnetic cell separations of human NK cells using a new type of magnetic bead. J Immunol Methods 129: 165-173, 1990.
26. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium fhiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
27. Marzluff WF and Huang RC: In: Transcription and Translation: A Practical Approach. Harnes BD and Higgins SJ (eds). IRL Press, Oxford, 1984.
28. Staerk Laursen L, Stokholm M, Bukhave K, Rask-Madsen J and Lauritsen K: Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion. Gut 31: 1271-1276, 1990.
29. Taylor BS, de Vera ME, Ganster RW, Wang Q, Shapiro RA, Morris SM, Billiar T and Geller D: Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem 273: 15148-15156, 1998.
30. Taniguchi T, Harada H and Lamphier M: Regulation of the interferon system and cell growth by the IRF transcription factors. J Cancer Res Clin Oncol 121: 516-520, 1995.
31. Taniguchi T: IRF-1 and IRF-2 as regulators of the interferon system and cell growth. Indian J Biochem Biophys 32: 235-239, 1995.
32. Farivar RS and Brecher P: Salicylate is a transcriptional inhibitor of the inducible nitric oxide synthase in cultured cardiac fibroblasts. J Biol Chem 271: 31585-31592, 1996.
33. Farivar RS, Chobanian AV and Brecher P: Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts. Circ Res 78: 759-768, 1996.
34. Amin AR, Vyas P, Attur M, Leszcynska-Piziak J, Patel IR, Weissmann G and Abramson SB: The mode of action of aspirinlike drugs: effect on inducible nitric oxide synthase. Proc Natl Acad Sei USA 92: 7926-7930, 1995.
35. Miller MJ, Chotinaruemol S, Sadowski-Krowicka H, Kakkis JL, Munshi UK, Zhang XJ and Clark DA: Nitric oxide: the Jekyll and Hyde of gut inflammation. Agents Actions 39: C180-C182, 1993.
36. Ribbons RA, Zhang XJ, Thompson JH, Greenberg SS, Moore SS, Kornmeier CM, Currie MG, Lerche N, Blanchard J, Clark DA and Miller MJS: Potential role of nitric oxide in a model of chronic colitis in rhesus macaques. Gastroenterology 108: 705-711, 1995.
37. McCafferty DM, Mudgett JS, Swain MG and Kubes P: Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 112: 1022-1027, 1997.
38. Ribbons KA, Currie MG, Connor JR, Manning PT, Allen PC, Didier P, Ratterree MS, Clark DA and Miller MJS: The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey. J Pharmacol Exp Ther 280: 1008-1015, 1997.
39. MacPherson BR and Pfeiffer CJ: Experimental production of diffuse colitis in rats. Digestion 17: 135-150, 1978.
40. Wong PY, Yue G, Yin K, Liy P, Lin M, Rodriquez A, Nomen M, Spur BW, Geng JG, Spökas EG and Sun FF: Anti-P-selectin antibody exacerbated inflammatory responses in acetic acidinduced colitis. Adv Exp Med Biol 433: 323-326, 1997.
41. Higa A, Eto T and Nawa Y: Evaluation of the role of neutrophils in the pathogenesis of acetic acid-induced colitis in mice. Scand J Gastroenterol 32: 564-568, 1997.
42. Yamada T, Zimmerman B J, Specian RD and Grisham MB: Role of neutrophils in acetic acid-induced colitis in rats. Inflammation 15:399-411, 1991.
43. Thomas TK, Will PC, Strivastava A, Wilson CL, Harbison M, Little J, Chesonis RS, Pignatello M, Schmölze D and Symington J: Evaluation of an interleukin-1 receptor antagonist in the rat acetic acid-induced colitis model. Agents Actions 34: 187-190, 1991.