5-Aminosalicylic acid inhibits the impaired epithelial barrier function induced by gamma interferon

Gut

Volumn 38, Issue 1, 1996, Pages 115-119

  Di Paolo, M C ^a   Merrett, M N ^a   Crotty, B ^a   Jewell, D P ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

5 aminosalicylic acid; Epithelial barrier function; Interferon

Indexed keywords

GAMMA INTERFERON; HLA DR ANTIGEN; MESALAZINE; RECOMBINANT GAMMA INTERFERON;

ANTIGEN EXPRESSION; ARTICLE; CARCINOMA CELL; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0030048859     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.38.1.115     Document Type: Article

References (25)

1. Selby WS, Janossy G, Mason DY, Jewell DP. Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 1983; 53: 614-8.
2. Spencer J, Finn T, Isaacson PG. Expression of HLA-DR antigens on epithelium associated with lymphoid tissue in the human gastrointestinal tract. Gut 1986; 27: 153-7.
3. Fais S, Pallone F, Squarcia O, Biancone L, Ricci F, Paoluzzi P, et al. HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease. 1. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers. Clin Exp Immunol 1987; 68: 605-12.
4. DeMayer E, De Mayer-Giugnard J, eds. Production of IFN-gamma by T cells and modulation of T cells, B cells and NK activity by interferons. In: Interferons and other regulatory cytokines. New York: John Wiley, 1988: 221-73.
5. Sollid LM, Gaudernack G, Markussen G, Kvale D, Brandtzaeg P, Thorsby E. Induction of various HLA Class II molecules in a human colonic adenocarcinoma cell line. Scand J Immunol 1987; 25: 175-80.
6. Crotty B, Hoang P, Dalton HR, Jewell DP. Salicylates used in inflammatory bowel disease and colchicine impair interferon-γ induced HLA-DR expression. Gut 1992; 33: 59-64.
7. Bloom S, Jewell DP. Induction of adhesion molecules by cytokines (interferon-gamma, interleukin 1, tumour necrosis factor alfa, interleukin 6) on the surface of HT29 and 1407. Gut 1991; 32: A1239.
8. Kaiserlian D, Rigal D, Abelo J, Revillard JP. Expression, function and regulation of the intercellular adhesion molecule-1 (ICAA1-I) on human intestinal epithelial cell lines. Eur J Immunol 1991; 21: 2415-21.
9. Hoang P, Crotty B, Dalton HR, Jewell DP. Epithelial cells bearing class II molecules stimulate allogeneic human colonic intraepithelial lymphocytes. Gut 1992; 33: 1089-93.
10. Mayer L, Schlein R. Evidence for function of Ia molecules on gut epithelial cells in man. J Exp Med 1987; 166: 1471-83.
11. Crotty B, Rosenberg WMC, Aronson JK, Jewell DP. Inhibition of binding of interferon-γ to its receptor by salicylates used in inflammatory bowel disease. Gut 1992; 33: 1353-7.
12. Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989; 83: 724-7.
13. Colgan SP, Parkos CA, Mathews JB, D'Andrea L, Awtrey CS, Lichtman AH, et al. Interferon-γ induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J Physiol 1994; 267: C402-10.
14. Perdue MH, McKay DM. Integrative immunophysiology in the intestinal mucosa. Am J Physiol 1994; 267: G151-65.
15. Augeron C, Laboisse CL. Emergency of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate. Cancer Res 1984; 44: 3961-9.
16. Lauritsen K, Hansen J, Ryde M, Rask-Madsen J. Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterology 1984; 86: 1496-500.
17. Laursen LS, Stokholm M, Bukhave K, Rask-Madsen J, Lauritsen K. Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colins: comparison of intraluminal colonic concentrations, serum values, and urinary excretion. Gut 1990; 31: 1271-6.
18. Madara JL, Trier JS. Functional morphology of the mucosa of the small intestine. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press, 1986: 1209-50.
19. Ellory JC. Flux measurements. Shannon: Elsevier North-Holland Scientific, 1982.
20. Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989; 96: 736-49.
21. Ucer U, Bartsch H, Scheurich P, Pfizenmaier K. Biological effects of γ-interferon on human tumour cells: quantity and affinity of cell membrane receptors for IFN-γ in relation to growth inhibition and induction of HLA-DR expression. Int J Cancer 1985; 36: 103-8.
22. McRoberts JA, Barrett KE. Hormone-regulated ion transport in T84 colonic cells. In: Marlin KS, Valentich JD, eds. Functional epithelial cells in culture. New York: Liss, 1989: 235-65.
23. McRoberts JA, Riley NE. Regulation of T84 cell monolayers permeability by insulin-like growth factors. Am J Physiol 1992; 262: C207-13.
24. Ireland A, Lowes JR, Jewell DP. Acetylation of 5-aminosalicylic acid (5-ASA) and 4-ASA by the HT29 colonic epithelial cell line. Gastroenterology 1990; 98: A545.
25. 51Cr-EDTA in patients with active inflammatory bowel disease. Clin Invest Med 1988; 11: 151-5.