Frequencies of multiple IgL chain gene rearrangements in single normal or κL chain-deficient B lineage cells

Immunity

Volumn 11, Issue 3, 1999, Pages 317-327

  Yamagami, Tamotsu ^a   Ten Boekel, Edwin ^a   Andersson, Jan ^a   Rolink, Antonius ^a   Melchers, Fritz ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL SPECIFICITY; GENE FREQUENCY; GENE LOCUS; GENE REARRANGEMENT; HETEROZYGOSITY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0033198563     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80107-7     Document Type: Article

References (41)

1. Arakawa, H., Shimizu, T., and Takeda, S. (1996). Re-evaluation of the probabilities for productive arrangements on the kappa and lambda loci. Int. Immunol. 8, 91-99.
2. Chen, J., Trounstine, M., Kurahara, C., Young, F., Kuo, C.C., Xu, Y., Loring, J.F., Alt, F.W., and Huszar, D. (1993). B cell development in mice that lack one or both immunoglobulin κ light chain genes. EMBO J. 12, 821-830.
3. Chen, C., Radic, M.Z., Erikson, J., Camper, S.A., Litwin, S., Hardy, R.R., and Weigert, M. (1994). Deletion and editing of B cells that express antibodies to DNA. J. Immunol. 152, 1970-1982.
4. Coleclough, C., Perry, R.P., Karlajainen, K., and Weigert, M. (1981). Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290, 372-378.
5. Feddersen, R.M., and Van Ness, B.G. (1985). Double recombination of a single immunoglobulin κ-chain allele: Implications for the mechanism of rearrangement. Proc. Natl. Acad. Sci. USA 82, 4793-4797.
6. Feddersen, R.M., Martin, D.J., and Van Ness, B.G. (1990). The frequency of multiple recombination events occurring at the human Ig kappa L chain locus. J. Immunol. 144, 1088-1093.
7. Ghia, P., Gratwohl, A., Signer, E., Winkler, T.H., Melchers, F., and Rolink, A.G. (1995). Immature B cells from human and mouse bone marrow can change their surface light chain expression. Eur. J. Immunol. 25, 3108-3114.
8. Gorman, J.R., and Alt, F.W. (1998). Regulation of immunoglobulin light chain isotype expression. Adv. Immunol. 69, 113-181.
9. Grawunder, U., Leu, T.M.J., Schatz, D.G., Werner, A., Rolink, A.G., Melchers, F., and Winkler, T.H. (1995). Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 3, 601-608.
10. Harada, K., and Yamagishi, H. (1991). Lack of feedback inhibition of Vκ gene rearrangement by productively rearranged alleles. J. Exp. Med. 173, 409-415.
11. Hartley, S.B., Cooke, M.P., Fulcher, P.A., Harris, A.W., Cory, S., Basten, A., and Goodnow, C.C. (1993). Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death. Cell 72, 325-335.
12. - bone marrow B cells in vitro. Immunity 6, 429-436.
13. Hertz, M., Kouskoff, V., Nakamura, T., and Nemazee, D. (1998). V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signaling. Nature 394, 292-295.
14. Kirschbaum, T., Jaenichen, R., and Zachau, H.G. (1996). The mouse immunoglobulin κ locus contains about 140 variable gene segments. Eur. J. Immunol. 26, 1613-1620.
15. Kofler, R., Geley, S., Kofler, H., and Helmberg, A. (1992). Mouse variable-region gene families: Complexity, polymorphism and use in non-autoimmune responses. Immunol. Rev. 128, 5-21.
16. Lam, K.P., Kuhn, R., and Rajewsky, K. (1997). In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083.
17. Langman, R.E., and Cohn, M. (1992). What determines the κ/λ ratio. In 47th Forum in Immunology, R.E. Langman and M. Cohn, eds. (Paris: Institut Pasteur/Elsevier), pp. 803-839.
18. Luning Prak, E., and Weigert, M. (1995). Light chain replacement: A new model for antibody gene rearrangement. J. Exp. Med. 182, 541-548.
19. Luning Prak, E., Trounstine, M., Huszar, D., and Weigert, M. (1994). Light chain editing in kappa-deficient animals: A potential mechanism of B cell tolerance. J. Exp. Med. 180, 1805-1815.
20. Melamed, D., Benschop, R.J., Cambier, J.C., and Nemazee, D. (1998). Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92, 173-182.
21. Melchers, F. (1999). Fit for life in the immune system? Surrogate L chain tests H chains that test L chains. Proc. Natl. Acad. Sci. USA 96, 2571-2573.
22. Mostoslavsky, R., Singh, N., Kirillov, A., Pelanda, R., Cedar, H., Chess, A., and Bergman, Y. (1998). Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12, 1801-1811.
23. Nadel, B., Cazenave, P.A., and Sanchez, P. (1990). Murine lambda gene rearrangements: The stochastic model prevails over the ordered model. EMBO J. 9, 435-440.
24. Pelanda, R., Schaal, S., Torres, R.M., and Rajewsky, K. (1996). A prematurely expressed Igκ transgene, but not a VκJκ gene segment targeted into the Igk locus, can rescue B cell development in λ5-deficient mice. Immunity 5, 229-239.
25. Radic, M.Z., Erikson, J., Litwin, S., and Weigert, M. (1993). B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177, 1165-1173.
26. Ramsden, D.A., and Wu, G.E. (1991). Mouse k light-chain recombination signal sequences mediate recombination more frequently than do those of λ light chain. Proc. Natl. Acad. Sci. USA 88, 10721-10725.
27. Retter, M.W., and Nemazee, D. (1998). Receptor editing occurs frequently during normal B cell development. J. Exp. Med. 188, 1231-1238.
28. + B cells can continue to rearrange κ and λ L chain gene loci. J. Exp. Med. 178, 1263-1270.
29. Rolink, A., Haasner, D., Nishikawa, S.I., and Melchers, F. (1993b). Changes in frequencies of clonable preB cells during life in different lymphoid organs of mice. Blood 81, 2290-2300.
30. Rolink, A.G., Andersson, J., and Melchers, F. (1998). Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur. J. Immunol. 28, 3738-3748.
31. Schlissel, M.S., and Stanhope-Baker, P. (1997). Accessibility and the developmental regulation of V(D)J recombination. Semin. Immunol. 9, 161-170.
32. Selsing, E., and Daitch, L.E. (1995). Immunoglobulin λ genes. In Immunoglobulin Genes (2nd Edition), T. Honjo and F.W. Alt, eds. (London: Academic Press), pp. 193-203.
33. Selsing, E., Voss, J., and Storb, U. (1984). Immunoglobulin gene "remnant" DNA - Implications for antibody gene recombination. Nucleic Acids Res. 15, 2699-2705.
34. Shapiro, M.A., and Weigert, M. (1987a). A complex translocation at the murine kappa light-chain locus. Mol. Cell. Biol. 7, 4130-4133.
35. κ genes rearrange. J. Immunol. 139, 3834-3839.
36. Shimizu, T., Iwasato, T., and Yamagishi, H. (1991). Deletions of immunoglobulin Cκ region characterized by the circular excision products in mouse splenocytes. J. Exp. Med. 173, 1065-1072.
37. Takeshita, S.,Toda, M., and Yamagishi, H. (1989). Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus. EMBO J. 8, 3261-3270.
38. Tiegs, S.L., Russell, D.M., and Nemazee, D. (1993). Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020.
39. -/- small pre-BII cells have no L-chain gene rearrangments: Detection by high efficiency single cell PCR. Immunity 11, 309-316.
40. Yelton, D.E., Desaymard, C., and Scharff, M.D. (1981). Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies. Hybridoma 1, 5-11.
41. Zou, Y.R., Takeda, S., and Rajewsky, K. (1993). Gene targeting in the Ig kappa locus: Efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa. EMBO J. 12, 811-820.