메뉴 건너뛰기




Volumn 9, Issue 5, 1997, Pages 380-386

Lymphocytes, cytokines, inflammation, and immune trafficking

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CALCIUM ION; CYTOKINE; DNA ANTIBODY; FAS ANTIGEN; GLYCOPROTEIN GP 39; INTERLEUKIN 10; LYMPHOCYTE RECEPTOR; MEMBRANE ANTIGEN; TYROSINE;

EID: 0030821695     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-199709000-00002     Document Type: Review
Times cited : (30)

References (57)
  • 1
    • 0027372258 scopus 로고
    • B-cell and T-cell function in systemic lupus erythematosus
    • Via CS, Handwerger BS: B-cell and T-cell function in systemic lupus erythematosus. Curr Opin Rheumatol 1993, 5:570-574.
    • (1993) Curr Opin Rheumatol , vol.5 , pp. 570-574
    • Via, C.S.1    Handwerger, B.S.2
  • 2
    • 0025954363 scopus 로고
    • Biochemical and molecular abnormalities in systemic lupus erythematosus
    • Tsokos GC: Biochemical and molecular abnormalities in systemic lupus erythematosus. Clin Exp Rheumatol 1992, 9:533-539.
    • (1992) Clin Exp Rheumatol , vol.9 , pp. 533-539
    • Tsokos, G.C.1
  • 4
    • 0003262391 scopus 로고
    • Overview of cellular Immune function in systemic lupus erythematosus
    • Edited by Lahita RG. New York: Churchill Livingstone
    • Tsokos GC: Overview of cellular Immune function in systemic lupus erythematosus. In Systemic Lupus Erythematosus, edn 2. Edited by Lahita RG. New York: Churchill Livingstone; 1992:15-50.
    • (1992) Systemic Lupus Erythematosus, Edn 2 , pp. 15-50
    • Tsokos, G.C.1
  • 5
    • 0028145041 scopus 로고
    • Lymphocytes, cytokines, inflammation, and immune trafficking
    • Tsokos GC: Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol 1994, 6:461-467.
    • (1994) Curr Opin Rheumatol , vol.6 , pp. 461-467
    • Tsokos, G.C.1
  • 6
    • 0029117670 scopus 로고
    • Lymphocytes, cytokines, inflammation, and immune trafficking
    • Tsokos GC: Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol 1995, 7:376-383.
    • (1995) Curr Opin Rheumatol , vol.7 , pp. 376-383
    • Tsokos, G.C.1
  • 7
    • 0029852061 scopus 로고    scopus 로고
    • Lymphocytes, cytokines, inflammation, and immune trafficking
    • Tsokos GC: Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol 1996, 8:395-402.
    • (1996) Curr Opin Rheumatol , vol.8 , pp. 395-402
    • Tsokos, G.C.1
  • 9
    • 0028915916 scopus 로고
    • Receptors for immunoglobulin G: Molecular diversity and implications for disease
    • Kimberly RP, Salmon JE, Edberg JC: Receptors for immunoglobulin G: molecular diversity and implications for disease. Arthritis Rheum 1995, 38:306-314.
    • (1995) Arthritis Rheum , vol.38 , pp. 306-314
    • Kimberly, R.P.1    Salmon, J.E.2    Edberg, J.C.3
  • 11
    • 0028919313 scopus 로고
    • The basis of autoimmunity. Part II: Genetic predisposition
    • Theofilopoulos AN: The basis of autoimmunity. Part II: genetic predisposition. Immunol Today 1995, 15:150-158.
    • (1995) Immunol Today , vol.15 , pp. 150-158
    • Theofilopoulos, A.N.1
  • 12
    • 0031027561 scopus 로고    scopus 로고
    • Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus
    • Tsao BP, Cantor RM, Kalunian KC, Chen CJ, Badsha H, Singh R, Wallace DJ, Kitridou RC, Chen SL, Shen N, et al.: Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. J Clin Invest 1997, 99:725-731. The distal end of chromosome 1 in murine models of lupus has been linked to manifestations of SLE. In this study, the human homologous region was analyzed using the microsatellite marker technique in 52 lupus-affected sibling pairs. A strong linkage was identified for the distal region 1q41-q42, which was unaffected even by ethnic differences among the patients in the study group. Even though the number of participating patient pairs did not have the statistical power to exclude localization of a susceptibility locus to other regions more proximal on chromosome 1, it certainly has enough power to localize a disease-susceptibility locus on this specific human chromosome.
    • (1997) J Clin Invest , vol.99 , pp. 725-731
    • Tsao, B.P.1    Cantor, R.M.2    Kalunian, K.C.3    Chen, C.J.4    Badsha, H.5    Singh, R.6    Wallace, D.J.7    Kitridou, R.C.8    Chen, S.L.9    Shen, N.10
  • 13
    • 0031568575 scopus 로고    scopus 로고
    • Susceptibility loci for lupus: A guiding light from murine models
    • Kotzin BL: Susceptibility loci for lupus: a guiding light from murine models [editorial]? J Clin Invest 1997, 99:557-558.
    • (1997) J Clin Invest , vol.99 , pp. 557-558
    • Kotzin, B.L.1
  • 15
    • 0028798616 scopus 로고
    • Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus
    • Desai-Mehta A, Mao C, Rajagopalan S, Robinson T, Datta SK: Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J Clin Invest 1995, 95:531-541.
    • (1995) J Clin Invest , vol.95 , pp. 531-541
    • Desai-Mehta, A.1    Mao, C.2    Rajagopalan, S.3    Robinson, T.4    Datta, S.K.5
  • 16
    • 0028858002 scopus 로고
    • Lupus: Key pathogenic mechanisms and contributing factors
    • Mohan C, Datta SK: Lupus: key pathogenic mechanisms and contributing factors. Clin Immunol Immunopathol 1995, 77:209-220.
    • (1995) Clin Immunol Immunopathol , vol.77 , pp. 209-220
    • Mohan, C.1    Datta, S.K.2
  • 17
  • 18
    • 0029965137 scopus 로고    scopus 로고
    • A few autoreactive cells in an autoimmune infiltrate control a vast population of non-specific cells: A tale of smart bombs and the infantry
    • Steinman L: A few autoreactive cells in an autoimmune infiltrate control a vast population of non-specific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci U S A 1996, 93:2253-2256.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2253-2256
    • Steinman, L.1
  • 19
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptor
    • Weiss A, Littman DR: Signal transduction by lymphocyte antigen receptor. Cell 1994, 76:263-274.
    • (1994) Cell , vol.76 , pp. 263-274
    • Weiss, A.1    Littman, D.R.2
  • 20
    • 0028346563 scopus 로고
    • Signal transduction by the B cell receptor and its coreceptors
    • Cambier JC, Pleiman CM, Clark MR: Signal transduction by the B cell receptor and its coreceptors. Annu Rev Immunol 1994, 12:457-486.
    • (1994) Annu Rev Immunol , vol.12 , pp. 457-486
    • Cambier, J.C.1    Pleiman, C.M.2    Clark, M.R.3
  • 21
    • 0026729146 scopus 로고
    • Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-γ2 in B lymphocytes
    • Coggeshall KM, McHugh JC, Altman A: Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-γ2 in B lymphocytes. Proc Natl Acad Sci U S A 1992, 89:5660-5664.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5660-5664
    • Coggeshall, K.M.1    McHugh, J.C.2    Altman, A.3
  • 22
    • 0029164734 scopus 로고
    • TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus
    • Vassilopoulos D, Kovacs B, Tsokos GC: TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J Immunol 1995, 137:2269-2281.
    • (1995) J Immunol , vol.137 , pp. 2269-2281
    • Vassilopoulos, D.1    Kovacs, B.2    Tsokos, G.C.3
  • 23
    • 0029829026 scopus 로고    scopus 로고
    • B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events
    • 2+ responses, which were associated with increased production of tyrosyl phosphorylated proteins. These findings were disease specific, disease activity independent, and unrelated to clinical manifestations or treatment, implying a possible pathogenic significance for SLE B cells.
    • (1996) J Clin Invest , vol.98 , pp. 2549-2557
    • Liossis, S.N.C.1    Kovacs, B.2    Dennis, G.3    Kammer, G.M.4    Tsokos, G.C.5
  • 24
    • 0029952074 scopus 로고    scopus 로고
    • Selective activation of the calcium signaling pathway by altered peptide ligands
    • Sloan-Lancaster J, Steinberg TH, Allen PM: Selective activation of the calcium signaling pathway by altered peptide ligands. J Exp Med 1996, 184:1525-1530.
    • (1996) J Exp Med , vol.184 , pp. 1525-1530
    • Sloan-Lancaster, J.1    Steinberg, T.H.2    Allen, P.M.3
  • 25
    • 0026537347 scopus 로고
    • CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding FA, McArthur JG, Gross JA, Raulet DH: CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992, 356:607-609.
    • (1992) Nature , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3    Raulet, D.H.4
  • 26
    • 0029810388 scopus 로고    scopus 로고
    • Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation
    • Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM: Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med 1996, 184:365-376.
    • (1996) J Exp Med , vol.184 , pp. 365-376
    • Boussiotis, V.A.1    Barber, D.L.2    Lee, B.J.3    Gribben, J.G.4    Freeman, G.J.5    Nadler, L.M.6
  • 27
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995, 182:459-465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 28
    • 0028238287 scopus 로고
    • B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus
    • Sfikakis PP, Oglesby R, Sfikakis P, Tsokos GC: B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus. Clin Exp Immunol 1994, 96:8-14.
    • (1994) Clin Exp Immunol , vol.96 , pp. 8-14
    • Sfikakis, P.P.1    Oglesby, R.2    Sfikakis, P.3    Tsokos, G.C.4
  • 29
    • 0029929607 scopus 로고    scopus 로고
    • Defective antigen-presenting cell function in patients with systemic lupus erythematosus: Role of the B7-1 (CD80) costimulatory molecule
    • Tsokos GC, Kovacs B, Sfikakis PP, Theocharis S, Vogelgesang SA, Via CS: Defective antigen-presenting cell function in patients with systemic lupus erythematosus: role of the B7-1 (CD80) costimulatory molecule. Arthritis Rheum 1996, 39:600-609.
    • (1996) Arthritis Rheum , vol.39 , pp. 600-609
    • Tsokos, G.C.1    Kovacs, B.2    Sfikakis, P.P.3    Theocharis, S.4    Vogelgesang, S.A.5    Via, C.S.6
  • 31
    • 0029862164 scopus 로고    scopus 로고
    • Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
    • Koshy M, Berger D, Crow MK: Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J Clin Invest 1996, 98:826-837. The expression, regulation, and function of the CD40 ligand on SLE lymphocytes-which is part of the very important pair of costimulatory molecules CD40 and CD40 ligand-were addressed in this study. Increased and prolonged expression of the CD40 ligand was shown on lupus T cells compared with normal T cells. CD40 ligand was elegantly shown to retain functional properties using as a measure the increased induced upregulation of B7-1 on a B-cell line.
    • (1996) J Clin Invest , vol.98 , pp. 826-837
    • Koshy, M.1    Berger, D.2    Crow, M.K.3
  • 32
    • 0029913381 scopus 로고    scopus 로고
    • Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
    • Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK: Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996, 97:2063-2073. This study not only demonstrates abnormalities in the expression and regulation of the CD40 ligand on lupus T cells but also reveals the surprising finding that B cells from patients with SLE are highly and intensely positive for CD40 ligand. The expression of CD40 ligand on T cells was related to disease activity, but the regulation of this molecule was not only abnormal but also, and more importantly, disease activity independent. The appearance of the CD40 ligand on the surface of peripheral B cells was verified by polymerase chain reaction analysis, and the functionality of the molecule was ingeniously shown by inhibition of anti-DNA antibody production using an anti-CD40 ligand monoclonal antibody.
    • (1996) J Clin Invest , vol.97 , pp. 2063-2073
    • Desai-Mehta, A.1    Lu, L.2    Ramsey-Goldman, R.3    Datta, S.K.4
  • 33
    • 0023114332 scopus 로고
    • The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin crosslinkage to the Fcγ receptor
    • Wilson HA, Greenblatt D, Taylor CW, Putney JW, Tsien RY, Finkelman FD, Chused TM: The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin crosslinkage to the Fcγ receptor. J Immunol 1987, 138:1712-1718.
    • (1987) J Immunol , vol.138 , pp. 1712-1718
    • Wilson, H.A.1    Greenblatt, D.2    Taylor, C.W.3    Putney, J.W.4    Tsien, R.Y.5    Finkelman, F.D.6    Chused, T.M.7
  • 34
    • 0018776991 scopus 로고
    • Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus
    • Frank MM, Hamburger MI, Lawley TJ, et al.: Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 1993, 300:518-523.
    • (1993) N Engl J Med , vol.300 , pp. 518-523
    • Frank, M.M.1    Hamburger, M.I.2    Lawley, T.J.3
  • 35
    • 0027477557 scopus 로고
    • Rote of the CD45 tyrosine phosphatase in signal transduction in the immune system
    • Koretzky GA: Rote of the CD45 tyrosine phosphatase in signal transduction in the immune system. FASEB J 1993, 7:420-426.
    • (1993) FASEB J , vol.7 , pp. 420-426
    • Koretzky, G.A.1
  • 36
    • 0029986670 scopus 로고    scopus 로고
    • Cell-type specificity of anti-CD45 autoantibodies in systemic lupus erythematosus
    • Czyzyk J, Fernsten P, Shaw M, Winfield JB: Cell-type specificity of anti-CD45 autoantibodies in systemic lupus erythematosus. Arthritis Rheum 1996, 39:592-599.
    • (1996) Arthritis Rheum , vol.39 , pp. 592-599
    • Czyzyk, J.1    Fernsten, P.2    Shaw, M.3    Winfield, J.B.4
  • 38
    • 0029867033 scopus 로고    scopus 로고
    • Disease severity in patients with systemic lupus erythematosus correlates with increased ratio of interleukin-10: Interferon-gamma-secreting cells in the peripheral blood
    • Hagiwara E, Gourley MF, Lee S, Klinman DM: Disease severity in patients with systemic lupus erythematosus correlates with increased ratio of interleukin-10: interferon-gamma-secreting cells in the peripheral blood. Arthritis Rheum 1996, 39:379-385.
    • (1996) Arthritis Rheum , vol.39 , pp. 379-385
    • Hagiwara, E.1    Gourley, M.F.2    Lee, S.3    Klinman, D.M.4
  • 40
    • 0028147255 scopus 로고
    • Expression and function of Fas antigen and bcl-2 in human systemic lupus erythematosus lymphocytes
    • Ohsako S, Hara M, Harigai M, Fukasawa C, Kashiwazaki S: Expression and function of Fas antigen and bcl-2 in human systemic lupus erythematosus lymphocytes. Clin Immunol Immunopathol 1994, 73:109-114.
    • (1994) Clin Immunol Immunopathol , vol.73 , pp. 109-114
    • Ohsako, S.1    Hara, M.2    Harigai, M.3    Fukasawa, C.4    Kashiwazaki, S.5
  • 41
    • 0028330345 scopus 로고
    • Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus
    • Emlen W, Niebur J, Kadera R: Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994, 152:3685-3692.
    • (1994) J Immunol , vol.152 , pp. 3685-3692
    • Emlen, W.1    Niebur, J.2    Kadera, R.3
  • 42
    • 0030839580 scopus 로고    scopus 로고
    • Increased expression of functional Fas ligand in activated T cells from patients with systemic lupus erythematosus
    • in press
    • Kovacs B, Liossis SNC, Dennis GJ, Tsokos GC: Increased expression of functional Fas ligand in activated T cells from patients with systemic lupus erythematosus. Autoimmunity 1997, in press.
    • (1997) Autoimmunity
    • Kovacs, B.1    Liossis, S.N.C.2    Dennis, G.J.3    Tsokos, G.C.4
  • 43
    • 1842334483 scopus 로고    scopus 로고
    • In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases
    • Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B, Kalden JR: In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1997, 40:306-317.
    • (1997) Arthritis Rheum , vol.40 , pp. 306-317
    • Lorenz, H.M.1    Grunke, M.2    Hieronymus, T.3    Herrmann, M.4    Kuhnel, A.5    Manger, B.6    Kalden, J.R.7
  • 44
    • 0029802697 scopus 로고    scopus 로고
    • Fas gene mutations in the Canale-Smith syndrome: An inherited lymphoproliferative disorder associated with autoimmunity
    • Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB: Fas gene mutations in the Canale-Smith syndrome: an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 1996, 335:1643-1649.
    • (1996) N Engl J Med , vol.335 , pp. 1643-1649
    • Drappa, J.1    Vaishnaw, A.K.2    Sullivan, K.E.3    Chu, J.L.4    Elkon, K.B.5
  • 46
    • 0029737324 scopus 로고    scopus 로고
    • Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease
    • Wu J, Wilson J, He J, Xiang L, Schur PH, Mountz JD: Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. J Clin Invest 1996, 98:1107-1113.
    • (1996) J Clin Invest , vol.98 , pp. 1107-1113
    • Wu, J.1    Wilson, J.2    He, J.3    Xiang, L.4    Schur, P.H.5    Mountz, J.D.6
  • 48
    • 0028889990 scopus 로고
    • Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice
    • Reap EA, Leslie D, Abrahams M, Eisenberg RA, Cohen PL: Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice. J Immunol 1995, 154:936-943.
    • (1995) J Immunol , vol.154 , pp. 936-943
    • Reap, E.A.1    Leslie, D.2    Abrahams, M.3    Eisenberg, R.A.4    Cohen, P.L.5
  • 49
    • 0027477318 scopus 로고
    • Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan C, Adams S, Stanik V, Datta SK: Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 1993, 177:1367-1381.
    • (1993) J Exp Med , vol.177 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3    Datta, S.K.4
  • 50
    • 0030023574 scopus 로고    scopus 로고
    • Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis: Activation-induced death can occur without Fas receptor
    • Tucek-Szabo CL, Andjelik S, Lacy E, Elkon KB, Nikolic-Zugic J: Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis: activation-induced death can occur without Fas receptor. J Immunol 1996, 156:192-200.
    • (1996) J Immunol , vol.156 , pp. 192-200
    • Tucek-Szabo, C.L.1    Andjelik, S.2    Lacy, E.3    Elkon, K.B.4    Nikolic-Zugic, J.5
  • 52
    • 0023874728 scopus 로고
    • Tumour necrosis factor-alpha in murine autoimmune "lupus" nephritis
    • Jacob CO, McDevitt HO: Tumour necrosis factor-alpha in murine autoimmune "lupus" nephritis. Nature 1988, 331:356-358.
    • (1988) Nature , vol.331 , pp. 356-358
    • Jacob, C.O.1    McDevitt, H.O.2
  • 53
    • 0025016823 scopus 로고
    • Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: Relevance to genetic predisposition to systemic lupus erythematosus
    • Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDevitt HO: Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U S A 1990, 87:1233-1237.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1233-1237
    • Jacob, C.O.1    Fronek, Z.2    Lewis, G.D.3    Koo, M.4    Hansen, J.A.5    McDevitt, H.O.6
  • 54
    • 0030891492 scopus 로고    scopus 로고
    • Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus
    • Utz PJ, Hottelet M, Schur PH, Anderson P: Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J Exp Med 1997, 185:843-854.
    • (1997) J Exp Med , vol.185 , pp. 843-854
    • Utz, P.J.1    Hottelet, M.2    Schur, P.H.3    Anderson, P.4
  • 55
    • 0029910218 scopus 로고    scopus 로고
    • Impaired recovery and cytolytic function of CD56+ T and non-T cells in systemic lupus erythematosus following in vitro polyclonal T cell stimulation: Studies in unselected patients and monozygotic disease-discordant twins
    • Stohl W, Elliott JE, Hamilton AS, Deapen DM, Mack TM, Horwitz DA: Impaired recovery and cytolytic function of CD56+ T and non-T cells in systemic lupus erythematosus following in vitro polyclonal T cell stimulation: studies in unselected patients and monozygotic disease-discordant twins. Arthritis Rheum 1996, 39:1840-1851. Peripheral blood mononuclear cells from a large number of patients with SLE and normal controls were polyclonally expanded, and the recovery of CD56+ T and non-T cells was determined. Significantly fewer CD56+ cells were recovered, and the cytolytic activity of this population was also found to be significantly decreased. This was not due to a lack of precursors but rather was the effect of impaired maturation of existing cells into the cytolytic effectors examined. More importantly, this effect was unrelated to disease activity or treatment and extended to the unaffected by SLE monozygotic twins of lupus patients. These data suggest that impaired generation of cytolytic CD56+ effectors may be inherent to the disease.
    • (1996) Arthritis Rheum , vol.39 , pp. 1840-1851
    • Stohl, W.1    Elliott, J.E.2    Hamilton, A.S.3    Deapen, D.M.4    Mack, T.M.5    Horwitz, D.A.6
  • 56
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994, 179:1317-1330.
    • (1994) J Exp Med , vol.179 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 57
    • 0029866102 scopus 로고    scopus 로고
    • Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus
    • Casciola-Rosen LA, Rosen A, Petri M, Schlissel M: Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci U S A 1996, 93:1624-1629.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 1624-1629
    • Casciola-Rosen, L.A.1    Rosen, A.2    Petri, M.3    Schlissel, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.