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0032481058
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Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
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Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH et al.: Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 1998, 396:433-439. A mouse with a deletion in the PSD-95 gene is shown to have enhanced LTP and to have lost the capacity for long-term depression (LTD). The animals are severely impaired in spatial learning. The findings demonstrate an interesting regulatory function for PSD-95 in controlling the balance between LTP and LTD, presumably by regulating the clustering of signaling molecules in close proximity to NMDA receptors. In addition, the results demonstrate that enhancing LTP will not necessarily improve memory ability.
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(1998)
Nature
, vol.396
, pp. 433-439
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Migaud, M.1
Charlesworth, P.2
Dempster, M.3
Webster, L.C.4
Watabe, A.M.5
Makhinson, M.6
He, Y.7
Ramsay, M.F.8
Morris, R.G.9
Morrison, J.H.10
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48
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0029098659
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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
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Kornau HC, Schenker LT, Kennedy MB, Seeburg PH: Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 1995, 269:1737-1740.
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(1995)
Science
, vol.269
, pp. 1737-1740
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Kornau, H.C.1
Schenker, L.T.2
Kennedy, M.B.3
Seeburg, P.H.4
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