The blood-brain barrier in primary CNS lymphomas: Ultrastructural evidence of endothelial cell death

Neuro-Oncology

Volumn 1, Issue 2, 1999, Pages 89-100

  Molnár, Peter P ^a   O'Neill, Brian P ^b   Scheithauer, Bernd W ^b   Groothuis, Dennis R ^a,c,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d EVANSTON NORTHWESTERN HEALTHCARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CORTICOSTEROID;

ADULT; AGED; APOPTOSIS; ARTICLE; ASTROCYTOMA; BLOOD BRAIN BARRIER; CAPILLARY; CENTRAL NERVOUS SYSTEM TUMOR; ELECTRON MICROSCOPY; FEMALE; HUMAN; LARGE CELL LYMPHOMA; MALE; METABOLISM; MIDDLE AGED; MIXED CELL LYMPHOMA; PATHOLOGY; PERMEABILITY; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ADRENAL CORTEX HORMONES; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASTROCYTOMA; BLOOD-BRAIN BARRIER; CAPILLARIES; CENTRAL NERVOUS SYSTEM NEOPLASMS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; LYMPHOMA, LARGE-CELL, DIFFUSE; LYMPHOMA, MIXED-CELL, DIFFUSE; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; PERMEABILITY;

EID: 0033108223     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1093/neuonc/1.2.89     Document Type: Article

References (60)

1. Asher, E., Payne, C.M., and Bernstein, C. (1995) Evaluation of cell death in EBV-transformed lymphocytes using agarose gel electrophoresis, light microscopy and electron microscopy. II. Induction of non-classic apoptosis ("Para-apoptosis") by tritiated thymidine. Leuk. Lymphoma 19, 107-119.
2. Bashir, R., Chamberlain, M., Ruby, E., and Hochberg, F.H.(1996). T-cell infiltration of primary CNS lymphoma. Neurology 46, 440-444.
3. Bellamy, C.O.C., Malcomson, R.D.G., Harrison, D.J., and Wyllie, A.H. (1995) Cell death in health and disease: The biology and regulation of apoptosis. Semin. Cancer Biol. 6, 3-16.
4. Benharroch, D., Prinsloo, I., Goldstein, J., Brousset, P., Kachko, L., and Gopas, J.U.P. (1996) A comparison of distinct modes of tumor cell death in Hodgkin's disease using morphology and in situ DNA fragmentation. Ultrastruct. Pathol. 20, 497-507.
5. Bertossi, M., Virgintino, D., Maiorano, E., Occhiogrosso, M., and Roncali, L. (1997) Ultrastructural and morphometric investigation of human brain capillaries in normal and peritumoral tissues. Ultrastruct. Pathol. 21, 41-49.
6. Burger, P.C., and Scheithauer, B.W. (1994) Tumors of the central nervous system. In: Rosai, J. (Ed.) Atlas of Tumor Pathology, Third series, Fascicle 10. Washington, D.C.: Armed Forces Institute of Pathology.
7. Cheville, N.F. (1994) Ultrastructural Pathology. An Introduction to Interpretation. Ames, IA: Iowa State University Press.
8. Clarke, P.G.H. (1990) Developmental cell death: Morphological diversity and multiple mechanisms. Anat. Embryol. (Berl.) 181, 195-213.
9. Colliris, J.A., Schandl, C.A., Young, K.K., Vesely, J., and Willingham, M.C. (1997) Major DNA fragmentation is a late event in apoptosis. J. Histochem. Cytochem. 45, 923-934.
10. Corn, B.W., Marcus, S.M., Topham, A., Hauck, W., and Curran, W.J., Jr. (1997) Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in year 2000? Cancer 79, 2409-2413.
11. Cory, S. (1995) Regulation of lymphocyte survival by the bel 2 gene family. Annu. Rev. Immunol. 13, 513-43.
12. Crisby, M., Kallin, B., Thyberg, J., Zhivotovsky, B., Orrenius, S., Kostulas, V., and Nilsson, J. (1997) Cell death in human atherosclerotic plaques involves both oncosis and apoptosis. Atherosclerosis 130, 17-27.
13. Cummings, M.C., Winterford, C.M., and Walker, N.I. (1997) Apoptosis. Am. J. Surg. Pathol. 21, 88-101.
14. DeAngelis, L.M. (1993) Cerebral lymphoma presenting as a nonenhancing lesion on computed tomographic/magnetic resonance scan. Ann. Neurol. 33, 308-311.
15. Distelhorst, C.W., and Dubyak, G. (1998) Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: Resurrection of old theories by new findings. Blood 91, 731-734.
16. Grant, J.W., and Isaacson, P.G. (1992) Primary central nervous system lymphoma. Brain Pathol. 2, 97-109.
17. Haudenschild, C.C., and Schwartz, S.M. (1979) Endothelial regeneration. II. Restitution of endothelial continuity. Lab. Invest. 41, 407-418.
18. Hirano, A., Ghatak, N.R., Becker, N.H., and Zimmerman, H.M. (1974) A comparison of the fine structure of small blood vessels in intracranial and retroperitoneal malignant lymphomas. Acta Neuropathol. (Berl.) 27, 93-104.
19. Honma, T., and Hamasaki, T. (1996) Ultrastructure of multinucleated giant cell apoptosis in foreign-body granuloma. Virchows Archiv. 428, 165-176.
20. Kahaleh, M.B., Smith, E.A. Soma, Y., and LeRoy, E.C. (1988) Effect of lymphotoxin and tumor necrosis factor on endothelial and connective tissue cell growth and function. Clin. Immunol. Immunopathol. 49, 261-272.
21. Kaufmann, S.H. (1997) Apoptosis. Pharmacological and Therapeutic Opportunities. San Diego, CA: Academic Press.
22. Kobayashi, T., Shibuya, N., Yoshida, J., Kagemaya, N., Usui, K., Hara, M., Hirota, T., and Suchi, T. (1983) Malignant intracranial lymphoma - clinical and patho-immunological study. No Shinkei Geka 11, 917-924.
23. Lo, A.C., Houenou, L.J., and Oppenheim, R.W. (1995) Apoptosis in the nervous system: Morphological features, methods, pathology, and prevention. Arch. Histol. Cytol. 58, 139-149.
24. Lorenzen, J., Thiele, J., and Fischer, R. (1997) The mummified Hodgkin cell: Cell death in Hodgkin's disease. J. Pathol. 182, 288-298.
25. Madigan, M.C., and Penfold, P.L. (1997) Human retinoblastoma: A morphological study of apoptotic, leukocytic, and vascular elements. Ultrastruct. Pathol. 21, 95-107.
26. Maier, J.A.M., Morelli, D., Ménard, S., Colnaghi, M.I., and Balsari, A. (1996) Tumor-necrosis-factor-induced fibroblast growth factor-1 acts as a survival factor in a transformed endothelial cell line. Am. J. Pathol. 149, 945-952.
27. Majno, G., and Joris, I. (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146, 3-15.
28. Mantovani, A., Bussolino, F., and lntrona, M. (1997) Cytokine regulation of endothelial cell function: From molecular level to the bedside. Immunol. Today 18, 231-240.
29. Merrill, J.E., and Benveniste, E.N. (1996) Cytokines in inflammatory brain lesions: Helpful and harmful. Trends Neurosci. 19, 331-338.
30. Morgello, S. (1995) Pathogenesis and classification of primary central nervous system lymphoma: An update. Brain Pathol. 5, 383-393.
31. Negri, C., Donzelli, M., Bernardi, R., Rossi, L., Burkle, A., and Scovassi, A.I. (1997) Multiparametric staining to identify apoptotic human cells. Exp. Cell Res. 234, 174-177.
32. Neuwelt, E.A., Gumerlock, M.K., and Dahlborg, S.A. (1990) Lymphomas of the brain in adults. In: Youmans, J.R. (Ed.) Neurological Surgery, Vol. 5, Third edition. Philadelphia: W.B. Saunders. pp. 3137-3151.
33. Ochi, A., Shibata, S., and Mori, K. (1989) Ultrastructure of capillary permeability in malignant lymphoma. No Shinkel Geka 17, 1139-1143.
34. Ott, R.J., Brada, M., Flower, M.A., Babich, J.W., Cherry, S.R., and Deehan, B.J. (1991) Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma. Eur. J. Cancer 27, 1356-1361.
35. Piris, M.A., Pezzella, F., Martinez-Montero, J.C., Orradre, J.L., Villuendas, R., Sanchez-Beato, M., Cuena, R., Cruz, M.A., Martinez, B., Garrido, M.C., Gatter, K., Aiello, A., Delia, D., Giardini, R., and Rilke, F. (1994) p53 and bcl-2 expression in high-grade B-cell lymphomas: Correlation with survival time. Br. J. Cancer 69, 337-341.
36. Pirotte, B., Levivier, M., Goldman, S., Brucher, J.-M., Brotchi, J., and Hildebrand, J. (1997) Glucocorticoid-induced long-term remission in primary cerebral lymphoma: Case report and review of the literature. J. Neurooncol. 32, 63-69.
37. Pistoia, V. (1997) Production of cytokines by human B cells in health and disease. Immunol. Today 18, 343-350.
38. Plowman, P.N., and Wise, R.J. (1984) Intracerebral lymphoma deposits: Investigation and treatment. Int. J. Rad. Oncol. Biol. Phys. 10, 843-849.
39. Polunovsky, V.A., Wendt, C.H., lngbar, D.H., Peterson, M.S., and Bitterman, RB. (1994) Induction of endothelial cell apoptosis by TNF alpha: Modulation by inhibitors of protein synthesis. Exp. Cell Res. 214, 584-594.
40. Portera-Cailliau, C., Price, D.L., and Martin, L.J. (1997) Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J. Comp. Neurol. 378, 70-87.
41. Regan, R.F., Panter, S.S., Witz, A., and Tilly, J.L. (1995) Ultrastructure of excitotoxic neuronal death in murine cortical culture. Brain Res. 705, 188-198.
42. Reidy, M.A., and Schwartz, S.M. (1981) Endothelial regeneration. III. Time course of intimai changes after small defined injury to rat aortic endothelium. Lab. Invest. 44, 301-308.
43. Reidy, M.A., and Schwartz, S.M. (1983) Endothelial injury and regeneration. IV. Endotoxin: A nondenuding injury to aortic endothelium. Lab. Invest. 48, 25-34.
44. Romero, L.I., Zhang, D.-N., Herron, G.S., and Karasek, M.A. (1997) Interleukin-1 induces major phenotypic changes in human skin microvascular endothelial cells. J. Cell. Physiol. 173, 84-92.
45. Rojiani, A.M., and Dorovini-Zis, K. (1996) Glomeruloid vascular structures in glioblastoma multiforme: An immunohistochemical and ultrastructural study. J. Neurosurg. 85, 1078-1084.
46. Roy, S., and Sarkar, C. (1989) Ultrastructural study of micro-blood vessels in human brain tumors and peritumoral tissue. J. Neurooncol. 7, 283-294.
47. Savill, J. (1994) Apoptosis in disease. Eur. J. Clin. Invest. 24, 715-723.
48. Shibata, S. (1989) Ultrastructure of capillary walls in human brain tumors. Acta Neuropathol. 78, 561-571.
49. Schulte-Herman, N.R., Bursch, W., Grasl-Kraupp, B., Marian, B., Kahl-Rainer, P., and Ellinger, A.T.P. (1997) Concepts of cell death and application to carcinogenesis. Toxicol. Pathol. 25, 89-93.
50. Schwartz, L.M. (1995) The faces of death. Cell Death Differ. 2, 83-85.
51. Schwartz, S.M., Haudenschild, C.C., and Eddy, E.M. (1978) Endothelial regeneration. I. Quantitative analysis of initial stages of endothelial regeneration in rat aortic intima. Lab. Invest. 38, 568-580.
52. Sgonc, R., and Wick, G. (1994) Methods for the detection of apoptosis. Int. Arch. Allergy Immunol. 105, 327-332.
53. Slowik, M.R., Min, W., Ardito, T., Karsan, A., Kashgarian, M., and Pober, J.S. (1997) Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1 -converting enzyme-like protease-dependent and -independent pathways. Lab. Invest. 77, 257-267.
54. Tellez, C., VonRoenn, J., and Levy, R.M. (1997) Neoplasms of the central nervous system in acquired immunodeficiency syndrome. In: Berger, J.R., and Levy, R.M. (Eds.), AIDS and the Nervous System. Second edition. New York: Lippincott-Raven. pp. 705-720.
55. Tomlinson, F.H., Kurtin, P.J., Suman, V.J., Scheithauer, B.W., O'Fallon, J.R., Kelly, P.J., Jack, C.R., Jr., and O'Neill, B.P. (1995) Primary intracerebral malignant lymphoma: A clinicopathological study of 89 patients. J. Neurosurg. 82, 558-566.
56. Trump, B.F., Berezesky, I.K., Chang, S.H., and Phelps, P.C. (1997) The pathways of cell death: Oncosis, apoptosis, and necrosis. Toxicol. Pathol. 25, 82-88.
57. Tsai, E.Y., Yie, J., Thanos, D., and Goldfeld, A.E. (1996) Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/Jun. Mol. Cell. Biol. 16, 5232-5244.
58. Ueda, F., Takashima, T., Suzuki, M., Kadoya, M., Yamashita, J., and Kida, T. (1995) MR imaging of primary intracranial malignant lymphoma. Radiat. Med. 13, 51-57.
59. Vaquero, J., Martinez, R., Rossi, E., and Lopez, R. (1984) Primary cerebral lymphoma: The "ghost tumor." J. Neurosurg. 60, 174-176.
60. Wyllie, A.H. (1997) Apoptosis. An overview. Br. Med. Bull. 53, 451-685.