Ultrastructural and morphometric investigation of human brain capillaries in normal and peritumoral tissues

Ultrastructural Pathology

Volumn 21, Issue 1, 1997, Pages 41-49

  Bertossi, Mirella ^a,b   Maiorano, Eugenio ^a   Occhiogrosso, Michèle ^a   Roncali, Luisa ^a  

^a UNIVERSITY OF BARI   (Italy)

^b POLICLINICO   (Italy)

Author keywords

endothelium; human brain; morphometry; peritumoral capillaries; permeability

Indexed keywords

ADULT; ARTICLE; BRAIN CAPILLARY; BRAIN EDEMA; BRAIN TUMOR; CASE REPORT; ENDOTHELIUM CELL; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; PRIORITY JOURNAL; ULTRASTRUCTURE;

EID: 0031039178     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.3109/01913129709023246     Document Type: Article

References (63)

1. Hossmann KA. Morphological substrate of the bloodbrain barrier in human brain tumors. In: Klatzo I, Seitelberger F, eds. Brain Edema. New York: Springer; 1967:249-267.
2. Shibata S. Ultrastructure of capillary walls in human brain tumors. Acta Neuropathol (Berl). 1989;78:561-571.
3. Stewart PA, Hayakawa K, Farrell CL, Del Maestro RF. Quantitative study of microvessel ultrastructure in human peritumoral brain tissue: evidence for a blood-brain barrier defect. J Neurosurg. 1987;67:697-705.
4. Criscuolo GR. Possible relationship between vascular permeability factors, endothelial cells, and peritumoral brain edema: a neurosurgeon's perspective. In: Simionescu N, Simionescu M, eds. Endothelial Cell Dysfunctions. New York: Plenum; 1992:477-503.
5. Bruce JN, Criscuolo GR, Merrill MJ, Moquin RR, Blacklock JB, Oldfield EH. Vascular permeability induced by protein product of malignant brain tumors: inhibition by desamethasone. J Neurosurg. 1987;67:880-884.
6. Yamada K, Ushio Y, Hajakawa T, Kato A, Yamada N, Mogami H. Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model. J Neurosurg. 1982; 57:394-398.
7. Hossmann KA, Hurter T, Oschlies U. The effect of dexamethasone on serum protein extravasation and edema development in experimental brain tumors of cat. Acta Neuropathol (Berl). 1983;60:223-231.
8. Kaye AH, Morstyn G, Ashcroft RG. Uptake and retention of hematoporphyrin derivative in an in vivo/in vitro model of cerebral glioma. Neurosurgery. 1985;17:883-890.
9. Levin VA, Freeman-Dove W, Landhai HD. Permeability characteristics of brain adjacent to tumors in rats. Arch Neural. 1975;32:785-791.
10. Stewart PA, Hayakawa K, Hayakawa E, Farrell CL, Del Maestro RF. A quantitative study of blood-brain barrier permeability ultrastructure in a new rat glioma model. Acta Neuropathol (Berl). 1985;67:96-102.
11. Castejön OJ. Electron microscopic study of capillary wall in human cerebral edema. J Neumpathol Exp Neurol. 1980;39:296-328.
12. Castejön OJ. Submicroscopic changes of cortical capillary pericytes in human perifocal edema. J Submicrosc Cytol. 1984;16:601-618.
13. Castejön OJ. Electron microscopic observations of endothelial junctions in perifocal human brain edema: an interpretative study. J Submicrosc Cytol. 1985:17:105-114.
14. Castejön OJ. Ultrastructural alterations of human cortical capillary basement membrane in perifocal brain edema. J Submicrosc Cytol Pathol. 1988:20:519-536.
15. Hurter T. Experimental brain tumors and edema in rats, III: peritumorous edema. Exp Pathol. 1984:26:227-234.
16. Nakagawa H, Groothuis D, Blasberg RG. The effect of graded hypertonic intracarotid infusions on drug delivery to experimental RG-2 gliomas. Neurology. 1984:34:15711581.
17. Stewart PA, Farrell CL, Del Maestro RF. The effect of cellular microenvironment on vessels in the brain, I: vessel structure in tumour, peritumour and brain from humans with malignant glioma. Int J Radiât Biol. 1991:60:125-130.
18. Kleihues P, Burger PC, Scheithauer BW, Sobin LH. Histological Typing of Tumours of the Central Nervous System. WHO International Histological Classification of Tumours, 2d ed. Berlin: Springer; 1993.
19. Stewart PA, Farrell CR, Coomber BL Blood-brain barrier ultrastructure: beyond tight junctions. Ann NYAcad Sei. 1988:529:295-297.
20. Stewart PA, Hayakawa K, Akers MA, Vinters HV. A morphometric study of the blood-brain barrier in Alzheimer's disease. Lab Invest. 1992;67:734-742.
21. Frank RN, Turczyn TJ, Das A. Pericyte coverage of retinal and cerebral capillaries. Invest Ophthalmol Vis Sei. 1990; 31:999-1007.
22. Shepro D, Morel NML Pericyte physiology. FASEB J. 1994:7:1031-1038.
23. Simionescu M, Ghinea NM, Fixman A, et al. The cerebral microvasculature of the rat: structure and luminal surface properties during early development. J Submicrosc Cytol. 1988:20:243-261.
24. Tilton RG. Capillary pericytes: perspectives and future trends. J Electron Microsc Techn. 1991; 19:327-344.
25. Stewart PA, Magliocco M, Hayakawa K, et al. A quantitative analysis of blood-brain barrier ultrastructure in the aging human. Microvasc Res. 1987:33:270-282.
26. Brightman MW, Zis K, Anders J. Morphology of cerebral endothelium and astrocytes as determinants of the neural microenvironment. Acta Neuropathol (Berl). 1983;Suppl VIII:21-33.
27. Cervos-Navarro J, Artigas J, Mrsulja BJ. Morphofunctional aspects of the normal and pathological blood-brain barrier. Acta Neuropathol (Berl). 1983;Suppl Vlll:1-19.
28. Claudio L, Kress I, Norton WT, Brosnan CF. Increased vesicular transport and decreased mitochondria! content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis. Am J Pathol. 1989;135: 1157-1168.
29. Klatzo I. Disturbances of the blood-brain barrier in cerebrovascular disorders. Acta Neuropathol (Berl). 1983;Suppl VIII:81-88.
30. Westergaard E. The blood-brain barrier to horseradish peroxidase under normal and experimental conditions. Acta Neuropathol (Berl). 1977:39:181-187.
31. Westergaard E. Ultrastructural permeability properties of cerebral microvasculature under normal and experimental conditions after application of tracers. In: Cervös-Navarro J, Ferszt R, eds. Advances in Neurology: Brain Edema. New York: Raven; 1980:55-74.
32. Coomber BL, Stewart PA. Morphometric analysis of CMS microvascular endothelium. Microvasc Res. 1985:30:99115.
33. Coomber BL, Stewart PA. Three-dimensional reconstruction of vesicles in endothelium of blood-brain barrier versus highly permeable microvessels. Anat /fee. 1986;215: 256-261.
34. Lossinsky AS, Vorbrodt AW, Wisniewski HM. Ultracytochemical studies of vesicular and canalicular transport structures in the injured mammalian blood-brain barrier. Acta Neuropathol (Berl). 1983;61:239-245.
35. Petito C, Schaefer JA, Plum F. Ultrastructural characteristics of the brain and blood-brain barrier in experimental seizures. Brain Res. 1977:127:251-267.
36. Simionescu N, Simionescu M, Palade GE. Permeability of muscle capillaries to small heme-peptides: evidence for the existence of patent transendothelial channels. J Cell Biol. 1975;64:586-607.
37. Simionescu N, Simionescu M, Palade GE. Recent studies on vascular endothelium. Ann NYAcad Sei. 1976:275:6475.
38. Simionescu N, Simionescu M, Palade GE. Structural basis of permeability in sequential segments of the microvasculature of the diaphragm, II: pathways followed by microperoxidase across the endothelium. Microvasc Res. 1978; 15:17-36.
39. Noguchi Y, Yamamoto T, Shibata Y. Distribution of endothelial vesicles in the microvasculature of skeletal muscle and brain cortex of the rat, as demonstrated by tannic acid tracer analysis. Cell Tissue Res. 1986;246:487-494.
40. Raviola G, Butler JM. Unidirectional vesicular transport mechanism in retinal vessels. Invest Ophthalmol Vis Sei. 1983:24:1465-1474.
41. VanDeurs B. Vesicular transport of horseradish peroxidase from brain to blood in segments of the cerbral microvasculature in adult mice. Brain Res. 1977;124:1-8.
42. Wagner HJ, Pilgrim C, Brandt J. Penetration and removal of horseradish peroxidase injected into the cerebrospinal fluid. Acta Neuropathol (Berl). 1974:27:299-305.
43. Glees P, Hasan M, Voth D, Schwarz M. Fine structural features of the cerebral microvasculature in hydrocéphalie human infants: correlated clinical observations. Neurosurg Rev. 1989:12:315-321.
44. Roy D, Sarkar C. Ultrastructural study of micro blood vessels in human brain tumors and peritumoral tissue. J Neurooncol. 1989:7:283-292.
45. Vorbrodt AV, Lossinsky AS, Wisniewski HM, et al. Ultrastructural observations on the transvascular route of protein removal in vasogenic brain edema. Acta Neuropathol (Berl). 1985:66:265-273.
46. Castejôn OJ. Increased vesicular and vacuolar transport in traumatic human brain edema: a combined electron microscopy study and theoretical approach. J Submicrosc Cytol. 1984:16:359-369.
47. Calhoun CL, Mottaz JK. Capillary bed of rat cerebral cortex: the fine structure in the experimental cerebral infarction. Arch Neurol. 1966:15:320-328.
48. Camilleri JP. Fine structural capillary changes and basal lamina thickening in sclerodermia (progressive systemic sclerosis) and Raynaud's disease. Pathol Res Pract. 1984; 178:230-236.
49. Carson KA, Hanker JS. Basal lamina thickness and permeability to horseradish peroxidase of intraneural capillaries in diabetic mice. Microvasc Res. 1980:20:223-232.
50. Gazendam J, Houtoff HJ, Huitema S, Go KG. Cerebral edema formation and blood brain barrier impairment by intraventricular collagenase infusion. In: Go KG, Baethmann A, eds. Recent Progress in the Study and Therapy of Brain Edema. New York: Plenum; 1982;45-54.
51. Long DM. Microvascular changes in cold injury edema. In: Go KG, Baethmann A, eds. Recent Progress in Study and Therapy of Brain Edema. New York: Plenum; 1982:45-54.
52. Long DM, Hartman JF, French L. The ultrastructure of human cerebral edema. J Neuropathol Exp Neurol. 1966;25: 373-395.
53. McDonald LW, Hayes L. The role of capillaries in the pathogenesis of delayed radionecrosis of brain. Am J Pathol. 1967; 50:745-764.
54. Scheibe! AB, Duong Th, Jacobs R. Alzheimer's disease as a capillary dementia. Ann Med. 1989;21:103-107.
55. Tani E, Evans JP. Electron microscope studies of cerebral swelling, I: studies on the permeability of brain capillaries, using ferritin molecules as tracers. Acta Neuropathol. 1965:4:507-526.
56. Torack RM. Ultrastructure of capillary reaction to brain tumors. Arch Neurol. 1961;5:86-98.
57. Rhodin JAG. Ultrastructure of mammalian venous capillaries, venules, and small collecting veins. J Ultrastruct Res. 1968;25:452-500.
58. Cancilla PA, Baker RN, Pollock PS, Frommes SP. The reaction of pericytes of the central nervous system to exogenous proteins. Lab Invest. 1972;26:376-383.
59. Van Deurs B. Observations on the blood-brain barrier in hypertensive rats with particular references to phagocytic pericytes. J Ultrastruct Res. 1976;56:65-77.
60. Klatzo I, Chui E, Fujiwara K, Spatz M. Resolution of vasogenic brain edema. In: Cervos-Navarro J, Ferszt R, eds. Advances in Neurology. New York: Raven; 1980;28:359375.
61. Van Deurs B, Amtorp O. Blood-brain barrier in rats to hemepeptide microperoxidase. Neuroscience. 1978;3:737748.
62. Klatzo I. Pathophysiological aspects of brain edema. Acta Neuropathol (Berl). 1987;72:236-239.
63. Klatzo I. Evolution of brain edema concepts. Acta Neuropathol (Berl). 1994;S60:3-6.