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Volumn 38, Issue 5, 1999, Pages 708-711

"Base flipping": Photodamaged DNA-RNA duplexes are poor substrates for photoreactivating DNA-repair enzymes

Author keywords

DNA repair; DNA structures; DNA RNA hybrids photolyases; UV photolesions

Indexed keywords

DEOXYRIBODIPYRIMIDINE PHOTOLYASE; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA;

EID: 0033105505     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-3773(19990301)38:5<708::aid-anie708>3.0.co;2-8     Document Type: Article
Times cited : (23)

References (58)
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  • 20
    • 0032493753 scopus 로고    scopus 로고
    • d) evidence for base flipping with photolyases see reference [19] and: B. J. van de Berg, G. B. Sancar, J. Biol. Chem. 1998, 273, 20276-20284;
    • (1998) J. Biol. Chem. , vol.273 , pp. 20276-20284
    • Van De Berg, B.J.1    Sancar, G.B.2
  • 25
    • 0027299690 scopus 로고
    • Such hybrid duplexes are biologically relevant during DNA transcription, DNA replication, and RNA reverse transcription. For a detailed investigation of their conformation see for example: a) M. Egli, N. Usman, A. Rich, Biochemistry 1993, 32, 3221-3237;
    • (1993) Biochemistry , vol.32 , pp. 3221-3237
    • Egli, M.1    Usman, N.2    Rich, A.3
  • 30
    • 0027905034 scopus 로고
    • Other repair systems show also increased activity with increasing duplex instability. See for example: a) C. P. Selby, A. Sancar, Science 1993, 260, 53-58;
    • (1993) Science , vol.260 , pp. 53-58
    • Selby, C.P.1    Sancar, A.2
  • 40
    • 0024971180 scopus 로고
    • c) a small effect of the counter strand on the binding by photolyases was reported by: A. Kiener, I. Husain, A. Sancar, C. Walsh, J. Biol. Chem. 1989, 264, 13880-13887;
    • (1989) J. Biol. Chem. , vol.264 , pp. 13880-13887
    • Kiener, A.1    Husain, I.2    Sancar, A.3    Walsh, C.4
  • 56
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    • note
    • All thermodynamic experiments were performed in Tris/HCl buffer. ΔG is reported at 15°C. This allows the thermodynamic data to be compared more directly with the enzymatic repair kinetics, which were performed in a phosphate buffer (pH 7.0) at 15°C.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.