Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices

European Journal of Pharmacology

Volumn 309, Issue 1, 1996, Pages 79-85

  Kemp, Martyn C ^a,b   Jane, David E ^a   Tse, Heong Wai ^a   Roberts, Peter J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Langford House   (United Kingdom)

Author keywords

Agonist; cAMP; Cerebral cortex slice; Metabotropic glutamate receptor

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 (2 CARBOXYCYCLOPROPYL)ALANINE; 2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 (CARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 2 METHYL 4 PHOSPHONOBUTYRIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2 METHYLGLUTAMIC ACID; ADENYLATE CYCLASE; CYCLIC AMP; FORSKOLIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; METABOTROPIC RECEPTOR; PHOSPHOSERINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030221654     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00314-7     Document Type: Article

References (47)

1. Abe, T., H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno and S. Nakanishi, 1992, Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction, J. Biol. Chem. 267, 13361.
2. Akazawa, C., H. Ohishi, Y. Nakajima, N. Okamoto, R. Shigemoto, S. Nakanishi and N. Mizuno, 1994, Expression of mRNA of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina, Neurosci. Lett. 171, 52.
3. Baskys, A. and R.C. Malenka, 1991, Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus, J. Physiol. 444, 687.
4. Bedingfield, J.S., M.C. Kemp, D.E. Jane, H.-W. Tse, P. J. Roberts and J.C. Watkins, 1995, Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (rnGluRs), Br. J. Pharmacol. 116, 3323.
5. Bedingfield, J.S., D.E. Jane, M.C. Kemp, N.J. Toms and P.J. Roberts, 1996, Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors, Eur. J. Pharmacol. 309, 71.
6. Brown, D.A., 1988, in: Ion Channels, Vol. 1, ed. T. Narahishi (Plenum Publishing Corporation, New York) p. 55.
7. Bushell, T.J., D.E. Jane, H.-W. Tse, J.C. Watkins, C.H. Davies and G.L. Collingridge, 1995, Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4, Neuropharmacology 34, 239.
8. Cassidy, E.M. and J.J. O'Connor, 1995, Effects of metabotropic glutamate receptor on paired pulse depression in the rat dentate gyrus in vivo, Br. J. Pharmacol. 116 (Proc. Suppl.), P106.
9. Chavis, P., H. Shinozaki, J. Bockaert and L. Fagni, 1994, The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a Pertussis toxin-sensitive G-protein in cultured cerebellar granule cells, J. Neurosci. 14, 7067.
10. Chavis, P., L. Fagni, J. Bockaert and J.B. Lansman, 1995, Modulation of calcium channels by metabotropic glutamate receptors in cerebellar granule cells, Neuropharmacology 34, 8, 929.
11. Davies, J. and J.C. Watkins, 1982, Actions of D and L forms 2-amino-5-phosphonobutyrate in the cat spinal cord. Brain Res. 235, 378.
12. Duvoisin, R.M., C. Zhang and K. Ramonell, 1995, A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb, J. Neurosci. 15, 3075.
13. East, S.J., M.P. Hill and J.M. Brotchie, 1995, Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes, Eur. J. Pharmacol. 277, 117.
14. 3H]-L-2-Amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a, Br, J. Pharmacol. 116, 3279.
15. Evans, R.H., A.A. Francis, A.W. Jones, D.A.S. Smith and J.C. Watkins, 1982, The effects of a series of ω-phosphonic and α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations, Br. J. Pharmacol. 75, 65.
16. Glaum, S.R. and R.J. Miller, 1995, Presynaptic metabotropic glutamate receptors modulate ω-conotoxin-GVIA-insensitive calcium channels in the rat medulla, Neuropharmacology 34, 8, 953.
17. Herrero, I., T. Miras-Portugal and J. Sanchez-Prieto, 1992, Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation, Nature (London) 360, 163.
18. Herrero, I., T. Miras-Portugal and J. Sanchez-Prieto, 1994, Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals, Eur. J. Neurosci. 6, 115.
19. Houamed, K.M., J.L. Kuijper, T.L. Gilbert, B.A. Haldeman, P.J. O'Hara, E.R. Mulvihill, W. Almers and F.S. Hagen, 1991, Cloning, expression and gene structure of a G protein-coupled glutamate receptor from rat brain, Science 252, 1318.
20. Ishida, M., T. Saitoh, K. Shimamoto, Y. Ohfune and H. Shinozaki, 1993, A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord, Br. J. Pharmacol. 109, 1169.
21. Jane, D.E., P.L.St.J. Jones, P.C.K. Pook, H.-W. Tse and J.C. Watkins, 1994. Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord, Br. J. Pharmacol. 112, 809.
22. Jane, D.E., K. Pittaway, D.C. Sunter, N.K. Thomas and J.C. Watkins, 1995. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord, Neuropharmacology 34, 851.
23. Kemp, M.C., P.J. Roberts, P.C.-K. Pook, D.E. Jane, A.W. Jones, P.L.St.J. Jones, D.C. Sunter, P.M. Udvarhelyi and J.C. Watkins, 1994, Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors, Eur. J. Pharmacol. 266, 187.
24. Knöpfel, T., R. Kuhn and H. Allgeier, 1995a, Metabotropic glutamate receptors: novel targets for drug development, J. Med. Chem. 38, 1417.
25. Knöpfel, T., S. Lukic, T. Leonardt, P.J. Flor, R. Kuhn and F. Gasparini, 1995b, Pharmacological characterisation of MCCG and MAP4 at the mGluR1b, mGkuR2 and mGluR4a human metabotropic glutamate receptor subtypes, Neuropharmacology 34, 8, 1099.
26. Koerner, J.F. and C.W. Cotman, 1981, Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex, Brain Res. 216, 192.
27. 2+ channels by two different metabotropic glutamate receptor subtypes, Soc. Neurosci. Abstr. 20.
28. Manzoni, O.J., P.E. Castillo and R.A. Nicoll, 1995, Pharmacology of metabotropic glutamate receptors at the mossy fiber synapses of the guinea pig hippocampus, Neuropharmacology 34, 965.
29. Masu, M., Y. Tanabe, K. Tsuchida, R. Shigemoto and S. Nakanishi, 1991, Sequence and expression of a metabotropic glutamate receptor, Nature (London) 349, 760.
30. Monaghan, D.T., R.J. Bridges and C.W. Cotman, 1989, The excitatory amino acids receptors: their classes, pharmacology and distinct properties in the function of the central nervous system, Annu. Rev. Pharmacol. Toxicol. 29, 365.
31. Nakajima, Y., H. Iwakabe, C. Akazawa, H. Nawa, R. Shigemoto, N. Mizuno and S. Nakanishi, 1993, Molecular characterisation of a novel retinal metabotropic glutamate receptor tnGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate, J. Biol. Chem. 268, 11868.
32. Nakanishi, S., 1995, Second order neurones and receptor mechanisms in visual-and olfactory-information processing, Trends Neurosci. 18, 359.
33. Ohishi, H., R. Shigemoto, S. Nakanishi and N. Mizuno, 1993, Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat, Neuroscience 53, 1009.
34. Okamoto, N., S. Hori, C, Akazawa, Y. Hayashi, R. Shigemoto, N. Mizuno and S. Nakanishi, 1994, Molecular characterization of a new metabotropic glutamate receptor rnGluR7 coupled to inhibitory cyclic AMP signal transduction, J. Biol. Chem. 269, 1231.
35. Pin, J.-P. and R. Duvoisin, 1995, The metabotropic glutamate receptors: structure and functions, Neuropharmacology 34, 1.
36. Pook, P.C.K., D.C. Sunter, P.M. Udvarhelyi and J.C. Watkins, 1992, Evidence for presynaptic depression of monosynaptic depression in neonatal rat motoneurones by (1S,3S)-and (1S,3R)-ACPD, Exp. Physiol. 77, 529.
37. 5 immunoreactivity in rat brain, J. Comp. Neurol. 355, 455.
38. Salt, T.E. and S.A. Eaton, 1995, Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo, Neuroscience 65, 5.
39. Saugstad, J.A., J.M. Kinzie, E.R. Mulvihill, T.P. Segerson, and G.L. Westbrook, 1994, Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid - sensitive class of metabotropic glutamate receptors, Mol. Pharmacol. 45, 367.
40. Schoepp, D.D. and J.P. Conn, 1993, Metabotropic glutamate receptors in brain function and pathology, Trends Pharmacol. Sci. 14, 13.
41. Shigemoto, R., S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi and N. Mizuno, 1993, Immunohistochemical localisation of a metabotropic glutamate receptor, mGluR5, in the rat brain, Neurosci. Lett. 163, 53.
42. Tanabe, Y., M. Masu, T. Ishii, R. Shigemoto and S. Nakanishi, 1992, A family of metabotropic glutamate receptors, Neuron 8, 169.
43. Tanabe, Y., A. Nomura, M. Masu, R. Shigemoto, N. Mizuno and S. Nakanishi, 1993, Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4, J. Neurosci, 13, 1372.
44. Thomsen. C., P. Kristensen, E. Mulvihill, B. Haldeman and P.D. Suzdak, 1992, L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase, Eur. J. Pharmacol. 227, 361.
45. Trombley, P.Q. and G.L. Westbrook, 1992, L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor, J. Neurosci. 12, 2043.
46. Vignes, M., V.R.J. Clarke, C.H. Davies, A. Chambers, D.E. Jane, J.C. Watkins and G.L. Collingridge, 1995, Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices, Neuropharmacology 34, 8, 973.
47. Watkins J. and G. Collingridge, 1994, Phenylglycine derivatives as antagonists of glutamate receptors, Trends Pharmacol. Sci. 15, 333.