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1
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0029731661
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Cross-talk between bacterial pathogens and their host cells
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Galán JE, Bliska JB Cross-talk between bacterial pathogens and their host cells. Annu Rev Cell Dev Biol. 12:1996;221-255.
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(1996)
Annu Rev Cell Dev Biol
, vol.12
, pp. 221-255
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Galán, J.E.1
Bliska, J.B.2
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2
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0029817221
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Identification of a pathogenicity island required for Salmonella survival in host cells
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Ochman H, Soncini FC, Solomon F, Groisman EA Identification of a pathogenicity island required for Salmonella survival in host cells. Proc Natl Acad Sci USA. 93:1996;7800-7804.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7800-7804
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Ochman, H.1
Soncini, F.C.2
Solomon, F.3
Groisman, E.A.4
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3
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0029913901
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Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium
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Shea JE, Hensel M, Gleeson C, Holden DW Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium. Proc Natl Acad Sci USA. 93:1996;2593-2597.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2593-2597
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Shea, J.E.1
Hensel, M.2
Gleeson, C.3
Holden, D.W.4
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4
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0024323292
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Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
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Galán JE, Curtiss RD Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells. Proc Natl Acad Sci USA. 86:1989;6383-6387.
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(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 6383-6387
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Galán, J.E.1
Curtiss, R.D.2
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5
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0031864184
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Type III protein secretion systems in bacterial pathogens of animals and plants
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A very useful and comprehensive catalogue of type III secretion systems in both animal and plant pathogenic bacteria.
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Hueck CJ Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Rev. 62:1998;379-433. A very useful and comprehensive catalogue of type III secretion systems in both animal and plant pathogenic bacteria.
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(1998)
Microbiol Rev
, vol.62
, pp. 379-433
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Hueck, C.J.1
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6
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0029879556
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Molecular genetic bases of Salmonella entry into host cells
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Galán JE Molecular genetic bases of Salmonella entry into host cells. Mol Microbiol. 20:1996;263-271.
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(1996)
Mol Microbiol
, vol.20
, pp. 263-271
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Galán, J.E.1
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7
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0030606233
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Pathogenicity islands - bacterial evolution in quantum leaps
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Groisman EA, Ochman H Pathogenicity islands - bacterial evolution in quantum leaps. Cell. 87:1996;791-794.
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(1996)
Cell
, vol.87
, pp. 791-794
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Groisman, E.A.1
Ochman, H.2
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8
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85030357230
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Salmonella typhimurium encodes an iron transport system within the centisome 63 pathogenicity island
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in press.
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Zhou D, Hardt W-D, Galán JE Salmonella typhimurium encodes an iron transport system within the centisome 63 pathogenicity island. Infect Immun. 1998;. in press.
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(1998)
Infect Immun
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Zhou, D.1
Hardt, W.-D.2
Galán, J.E.3
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9
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0032562678
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Supramolecular structure of the Salmonella typhimurium type III protein secretion system
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This paper demonstrates that the type III protein secretion apparatus forms a supramolecular structure on the bacterial envelope and provides the first glance at the architecture of this structure. The electron micrographs demonstrate that the type III secretion machinery spands both the inner and outer membrane ressembling the flagellar basal body structure. These studies also give support to the evolutionary relationship between type III secretion and flagellar assembly mechanisms.
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Kubori T, Matsushima Y, Nakamura D, Uralil J, Lara-Tejero M, Sukhan A, Galán JE, Aizawa S-I Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science. 280:1998;602-605. This paper demonstrates that the type III protein secretion apparatus forms a supramolecular structure on the bacterial envelope and provides the first glance at the architecture of this structure. The electron micrographs demonstrate that the type III secretion machinery spands both the inner and outer membrane ressembling the flagellar basal body structure. These studies also give support to the evolutionary relationship between type III secretion and flagellar assembly mechanisms.
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(1998)
Science
, vol.280
, pp. 602-605
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Kubori, T.1
Matsushima, Y.2
Nakamura, D.3
Uralil, J.4
Lara-Tejero, M.5
Sukhan, A.6
Galán, J.E.7
Aizawa, S.-I.8
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10
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0028957850
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Functional analysis of the Salmonella typhimurium invasion genes invI and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus
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Collazo CM, Zierler MK, Galán JE Functional analysis of the Salmonella typhimurium invasion genes invI and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus. Mol Microbiol. 15:1995;25-38.
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(1995)
Mol Microbiol
, vol.15
, pp. 25-38
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Collazo, C.M.1
Zierler, M.K.2
Galán, J.E.3
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11
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0029846007
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Requirement of exported proteins for secretion through the invasion-associated Type III system in Salmonella typhimurium
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Collazo C, Galán JE Requirement of exported proteins for secretion through the invasion-associated Type III system in Salmonella typhimurium. Infect Immun. 64:1996;3524-3531.
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(1996)
Infect Immun
, vol.64
, pp. 3524-3531
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Collazo, C.1
Galán, J.E.2
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12
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0030886017
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A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria
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Hardt W-D, Galán JE A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria. Proc Natl Acad Sci USA. 94:1997;9887-9892.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9887-9892
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Hardt, W.-D.1
Galán, J.E.2
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13
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0032478074
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A target of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage
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This paper shows that a substrate of the centisome 63 type III secretion apparatus of Salmonella typhimurium is encoded within the genome of a cryptic bacteriophage. Encoding substrates of type III secretion systems within highly mobile genetic elements may facilitate the rapid optimization of the set of effector proteins to be delivered to a given host or in a given environment.
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Hardt W-D, Urlaub H, Galán JE A target of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage. Proc Natl Acad Sci USA. 95:1998;2574-2579. This paper shows that a substrate of the centisome 63 type III secretion apparatus of Salmonella typhimurium is encoded within the genome of a cryptic bacteriophage. Encoding substrates of type III secretion systems within highly mobile genetic elements may facilitate the rapid optimization of the set of effector proteins to be delivered to a given host or in a given environment.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2574-2579
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Hardt, W.-D.1
Urlaub, H.2
Galán, J.E.3
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14
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0029059332
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Homologues of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
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Kaniga K, Tucker SC, Trollinger D, Galán JE Homologues of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. J Bacteriol. 177:1995;3965-3971.
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(1995)
J Bacteriol
, vol.177
, pp. 3965-3971
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Kaniga, K.1
Tucker, S.C.2
Trollinger, D.3
Galán, J.E.4
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15
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0028886418
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Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins
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Kaniga K, Trollinger D, Galán JE Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins. J Bacteriol. 177:1995;7078-7085.
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(1995)
J Bacteriol
, vol.177
, pp. 7078-7085
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Kaniga, K.1
Trollinger, D.2
Galán, J.E.3
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16
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0029839017
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A secreted tyrosine phosphatase with modular effector domains encoded by the bacterial pathogen Salmonella typhimurium
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Kaniga K, Uralil J, Bliska JB, Galán JE A secreted tyrosine phosphatase with modular effector domains encoded by the bacterial pathogen Salmonella typhimurium. Mol Microbiol. 21:1996;633-641.
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(1996)
Mol Microbiol
, vol.21
, pp. 633-641
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Kaniga, K.1
Uralil, J.2
Bliska, J.B.3
Galán, J.E.4
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17
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0030921542
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A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa
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This paper describes the identification of a new substrate of the centisome 63 type III secretion system that is implicated in the Salmonella-induced diarrhea.
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Galyov EE, Wood MW, Rosqvist R, Mullan PB, Watson PR, Hedges S, Wallis TS A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa. Mol Microbiol. 25:1997;1903-1912. This paper describes the identification of a new substrate of the centisome 63 type III secretion system that is implicated in the Salmonella-induced diarrhea.
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(1997)
Mol Microbiol
, vol.25
, pp. 1903-1912
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Galyov, E.E.1
Wood, M.W.2
Rosqvist, R.3
Mullan, P.B.4
Watson, P.R.5
Hedges, S.6
Wallis, T.S.7
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18
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0029806327
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SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry
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Wood MW, Rosqvist R, Mullan PB, Edwards MH, Galyov EE SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry. Mol Microbiol. 22:1996;327-338.
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(1996)
Mol Microbiol
, vol.22
, pp. 327-338
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Wood, M.W.1
Rosqvist, R.2
Mullan, P.B.3
Edwards, M.H.4
Galyov, E.E.5
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19
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0029560515
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Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins
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Hueck CJ, Hantman MJ, Bajaj V, Johnston C, Lee CA, Miller SI Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol Microbiol. 18:1995;479-490.
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(1995)
Mol Microbiol
, vol.18
, pp. 479-490
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Hueck, C.J.1
Hantman, M.J.2
Bajaj, V.3
Johnston, C.4
Lee, C.A.5
Miller, S.I.6
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20
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0031919952
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Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE
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Hong KH, Miller VL Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE. J Bacteriol. 180:1998;1793-1802.
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(1998)
J Bacteriol
, vol.180
, pp. 1793-1802
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Hong, K.H.1
Miller, V.L.2
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21
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0031007757
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The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell
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Collazo C, Galán JE The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell. Mol Microbiol. 24:1997;747-756.
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(1997)
Mol Microbiol
, vol.24
, pp. 747-756
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Collazo, C.1
Galán, J.E.2
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22
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0031801744
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Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium
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Fu Y, Galán JE Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium. J Bacteriol. 180:1998;3393-3399.
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(1998)
J Bacteriol
, vol.180
, pp. 3393-3399
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Fu, Y.1
Galán, J.E.2
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23
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0031983624
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The Salmonella spp. protein tyrosine phosphatase SptP is translocated into host cells and disrupts the host-cell cytoskeleton
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Fu Y, Galán JE The Salmonella spp. protein tyrosine phosphatase SptP is translocated into host cells and disrupts the host-cell cytoskeleton. Mol Microbiol. 27:1998;359-368.
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(1998)
Mol Microbiol
, vol.27
, pp. 359-368
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Fu, Y.1
Galán, J.E.2
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24
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0031928971
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Identification of a pathogenicity island required for Salmonella enteropathogenicity
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Wood MW, Jones MA, Watson PR, Hedges S, Wallis TS, Galyov EE Identification of a pathogenicity island required for Salmonella enteropathogenicity. Mol Microbiol. 29:1998;883-891.
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(1998)
Mol Microbiol
, vol.29
, pp. 883-891
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Wood, M.W.1
Jones, M.A.2
Watson, P.R.3
Hedges, S.4
Wallis, T.S.5
Galyov, E.E.6
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25
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0031613807
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'Avirulence genes' in animal pathogens?
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Galan JE 'Avirulence genes' in animal pathogens? Trends Microbiol. 6:1998;3-6.
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(1998)
Trends Microbiol
, vol.6
, pp. 3-6
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Galan, J.E.1
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26
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0031306875
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Involvement of the mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal cells
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This paper demonstrates that Salmonella typhimurium induces nuclear responses in intestinal epithelial cells through the function of the centisome 63 type III secretion system. These responses are characterized by the induction of specific transcription factors such as NF-κB and AP-1 and are the result of the activation of the mitogen-activated protein (MAP) kinase pathways. Activation of these nuclear responses leads to the production of pro-inflammatory cytokines, which is important for the induction of diarrhea.
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Hobbie S, Chen LM, Davis R, Galán JE Involvement of the mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal cells. J Immunol. 159:1997;5550-5559. This paper demonstrates that Salmonella typhimurium induces nuclear responses in intestinal epithelial cells through the function of the centisome 63 type III secretion system. These responses are characterized by the induction of specific transcription factors such as NF-κB and AP-1 and are the result of the activation of the mitogen-activated protein (MAP) kinase pathways. Activation of these nuclear responses leads to the production of pro-inflammatory cytokines, which is important for the induction of diarrhea.
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(1997)
J Immunol
, vol.159
, pp. 5550-5559
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Hobbie, S.1
Chen, L.M.2
Davis, R.3
Galán, J.E.4
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27
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0018305137
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Importance of the intestinal inflammatory reaction in Salmonella-mediated intestinal secretion
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Giannella RA Importance of the intestinal inflammatory reaction in Salmonella-mediated intestinal secretion. Infect Immun. 23:1979;140-147.
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(1979)
Infect Immun
, vol.23
, pp. 140-147
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Giannella, R.A.1
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29
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0025010979
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The GTPase superfamily
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a conserved switch for diverse cell functions
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Bourne HR, Sanders DA, McCormick F The GTPase superfamily. a conserved switch for diverse cell functions Nature. 348:1990;125-132.
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(1990)
Nature
, vol.348
, pp. 125-132
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Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
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30
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0030448437
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Requirement of CDC42 for Salmonella typhimurium-induced cytoskeletal reorganization and nuclear responses in cultured cell
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Chen LM, Hobbie S, Galán JE Requirement of CDC42 for Salmonella typhimurium-induced cytoskeletal reorganization and nuclear responses in cultured cell. Science. 274:1996;2115-2118.
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(1996)
Science
, vol.274
, pp. 2115-2118
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Chen, L.M.1
Hobbie, S.2
Galán, J.E.3
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31
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0032577563
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Salmonella typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
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This paper demonstrates that transient expression or microinjection of a substrate of the type III secretion system, SopE, is sufficient to stimulate Cdc42- and Rac-dependent cytoskeletal and nuclear responses that closely resemble those induced by Salmonella. SopE stimulates these responses by acting as an exchange factor for Rho GTPases, including Cdc42 and Rac. This paper therefore provides the molecular bases for the ability of Salmonella to stimulate nuclear and cytoskeletal responses through the type III secretion system and establishes a new paradigm by which bacterial agonists engage the cellular signaling machinery within the host cell.
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Hardt W-D, Chen L-M, Schuebel KE, Bustelo XR, Galán JE Salmonella typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell. 93:1998;815-826. This paper demonstrates that transient expression or microinjection of a substrate of the type III secretion system, SopE, is sufficient to stimulate Cdc42- and Rac-dependent cytoskeletal and nuclear responses that closely resemble those induced by Salmonella. SopE stimulates these responses by acting as an exchange factor for Rho GTPases, including Cdc42 and Rac. This paper therefore provides the molecular bases for the ability of Salmonella to stimulate nuclear and cytoskeletal responses through the type III secretion system and establishes a new paradigm by which bacterial agonists engage the cellular signaling machinery within the host cell.
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(1998)
Cell
, vol.93
, pp. 815-826
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Hardt, W.-D.1
Chen, L.-M.2
Schuebel, K.E.3
Bustelo, X.R.4
Galán, J.E.5
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32
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2642703408
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Delivery of epitopes by the Salmonella type III secretion system for vaccine development
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This paper provides a description of the use of the type III secretion for the delivery of viral epitopes to an MHC Class I antigen presenting compartment. The use of this system overcomes a severe limitation in the use of Salmonella as a carrier of heterologous antigens for vaccine development due to its intracellular localization within a membrane-bound compartment. This location hampers its ability to deliver epitopes to the Class I antigen presenting pathway. Type III secreted substrates are used as molecular couriers to deliver epitopes to the cytosol of infected cells thereby stimulating class I-restricted responses.
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Rüssmann H, Shams H, Poblete F, Fu Y, Galán JE, Donis RD Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science. 281:1998;565-568. This paper provides a description of the use of the type III secretion for the delivery of viral epitopes to an MHC Class I antigen presenting compartment. The use of this system overcomes a severe limitation in the use of Salmonella as a carrier of heterologous antigens for vaccine development due to its intracellular localization within a membrane-bound compartment. This location hampers its ability to deliver epitopes to the Class I antigen presenting pathway. Type III secreted substrates are used as molecular couriers to deliver epitopes to the cytosol of infected cells thereby stimulating class I-restricted responses.
-
(1998)
Science
, vol.281
, pp. 565-568
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Rüssmann, H.1
Shams, H.2
Poblete, F.3
Fu, Y.4
Galán, J.E.5
Donis, R.D.6
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