Expansion of neonatal tolerance to self in adult life: II. Tolerance preferentially spreads in an intramolecular manner

International Immunology

Volumn 11, Issue 6, 1999, Pages 907-913

  Grabie, Nir ^a   Karin, Nathan ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Experimental autoimmune encephalomyelitis; IL 4; Intramolecular deviation; Multiple sclerosis; Neonatal tolerance; T(h)1; T(h)2; Tolerizing T cells

Indexed keywords

MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IN VITRO STUDY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; FEMALE; INJECTIONS, INTRAPERITONEAL; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RATS; RATS, INBRED LEW; SELF TOLERANCE; T-LYMPHOCYTES;

EID: 0033062129     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.6.907     Document Type: Article

References (51)

1. Qin, Y. F., Sun, D. M., Goto, M., Meyermann, R. and Wekerle, H. 1989. Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination vs. regulation of autoaggressive lymphocytes. Eur. J. Immunol. 19:373.
2. Clayton, J. P., Gammon, G. M., Ando, D. G., Kono, D. H., Hood, L. and Sercarz, E. E. 1989. Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J. Exp. Med. 169:1681.
3. Vandenbark, A. A., Vainiene, M., Celnik, B., Hashim, G. A., Buenafe, A. and Offner, H. 1994. Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides. J. Immunol. 153:852.
4. Gammon, G. M., Oki, A., Shastri, N. and Sercarz, E. E. 1986. Induction of tolerance to one determinant on a synthetic peptide does not affect the response to a second linked determinant. Implications for the mechanism of neonatal tolerance induction. J. Exp. Med. 164:667.
5. Gammon, G., Don, K., Shastri, N., Oki, A., Wilbur, S. and Sercarz, E. E. 1986. Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature 309:413.
6. Ramsdell, F. and Fowlkes, B. J. 1990. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 248:1342.
7. Kappler, J., Roehm, N. and Marrack, P. 1987. T cell tolerance by clonal elemination in the thymus. Cell 49:273.
8. O'Garra, A. and Murphy, K. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6:458.
9. Abbas, A. K., Murphy, K. M. and Sher, A. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
10. h2-like helper effectors. J. Immunol. 145:3796.
11. Lederer, J. A., Perez, V. L., DesRoches, L., Kim, S. M., Abbas, A. K. and Lichtman, A. H. 1996. Cytokine transcriptional events during helper T cell subset differentiation. J. Exp. Med. 184:397.
12. + T cells to enhance priming for IFN-g production and diminishes IL-4 inhibition of such priming. Proc. Natl Acad. Sci. USA 90:10188.
13. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091.
14. h1 cells. J. Immunol. 146:3444.
15. h2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 9:145.
16. h2 responses. Immunol. Today 12:A49.
17. Huang, H., Hu-Li, J., Chen, H., Ben-Sasson, S. Z. and Paul, W. E. 1997. IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. J. Immunol. 159:3731.
18. h3 T cells by oral administration of myelin in multiple sclerosis patients. J. Clin. Invest. 98:70.
19. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
20. Singh, R. R., Hahn, B. H. and Sercarz, E. E. 1996. Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity [see comments]. J. Exp. Med. 183:1613.
21. Forsthuber, T., Yip, H. C. and Lehmann, P. V. 1996. Induction of TH1 and TH2 immunity in neonatal mice [see comments]. Science 271:1728.
22. Sarzotti, M., Robbins, D. S. and Hoffman, P. M. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus [see comments]. Science 271:1726.
23. Ridge, J. P., Fuchs, E. J. and Matzinger, P. 1996. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells [see comments]. Science 271:1723.
24. Karin, N., Binah, O., Grabie, N., Mitchel, D. J., Felzen, B., Solomon, M. D., Conlon, P., Gaur, A., Ling, N. and Steinman, L. 1998. Short peptide based tolerogens without antigenic activity reverse autoimmunity. J. Immunol. 160:5188.
25. Karin, N., Mitchell, J. D., Brocke, S., Ling, N. and Steinman, L. 1994. Reversal of experimental autoimmune encephalomyelitis by as soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of IFN-γ and TNF-α production. J. Exp. Med. 180:2227
26. Brocke, S., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., Blankenstein, T., Martin, R., Utz, U., Karin, N., Mitchell, D., et al. 1996. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379:343.
27. Karin, N., Szafer, F., Mitchell, D., Gold, D. P. and Steinman, L. 1993. Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis. J. Immunol. 150:4116.
28. Offner, H., Hashim, G. A., Celnik, B., Galang, A., Li, X. B., Burns, F. R., Shen, N., Heber-Katz, E. and Vandenbark, A. A. 1989. T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. J. Exp. Med. 170:355.
29. Offner, H., Vainiene, M., Gold, D. P., Celnik, B., Wang, R., Hashim, G. A. and Vandenbark, A. A. 1992. Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. T cell receptor peptide regulation of T cell clones expressing cross-reactive V beta genes. J. Immunol. 148:1706.
30. Lehmann, P. V., Forsthuber, T., Miller, A. and Sercarz, E. E. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
31. Mor, F. and Cohen, I. R. 1993. Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 92:2199.
32. McRae, B. L., Vanderlugt, C. L., Dal Canto, M. C. and Miller, S. D. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75.
33. Zhao, W., Wegmann, K. W., Trotter, J. L., Ueno, K. and Hickey, W. F. 1994. Identification of an N-terminally acetylated encephalitogenic epitope in myelin proteolipid apoprotein for the Lewis rat. J. Immunol. 153:901.
34. Olee, T., Powers, J. M. and Brostoff, S. W. 1988. A T cell epitope for experimental allergic neuritis. J. Neuroimmunol. 19:167.
35. Yednock, T. A., Cannon, C., Fritz, L. C., Sanchez, M. F., Steinman, L. and Karin, N. 1992. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 356:63.
36. Ben-Nun, A., Wekerle, H. and Cohen, I. R. 1981. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:195.
37. Pette, M., Fujita, K., Kitze, B., Whitaker, J. N., Albert, E., Kappos, L. and Wekerle, H. 1990. Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals. Neurology 40:1770.
38. Steinman, L. 1995. Escape from 'horror autotoxicus': pathogenesis and treatment of autoimmune disease. Cell 80:7.
39. Friedman, A. and Weiner, H. L. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl Acad. Sci. USA 91:6688.
40. Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. and Weiner, H. L. 1994. Regulatory T-cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
41. Khoury, S. J., Hancock, W. W. and Weiner, H. L. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176:1355.
42. Cash, E., Minty, A., Ferrara, P., Caput, D., Fradelizi, D. and Rott, O. 1994. Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats. J. Immunol. 153:4258.
43. Saoudi, A., Kuhn, J., Huygen, K., de, K. Y., Velu, T., Goldman, M., Druet, P. and Bellon, B. 1993. TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur. J. Immunol. 23:3096.
44. Critchfield, J. M., Racke, M. K., Zuniga, P. J., Cannella, B., Raine, C. S., Goverman, J. and Lenardo, M. J. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139.
45. Critchfield, J. M. and Lenardo, M. J. 1995. Antigen-induced programmed T cell death as a new approach to immune therapy [review]. Clin. Immunol. Immunopathol. 75:13.
46. Burstein, H. J. and Abbas, A. K. 1993. In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J. Exp. Med. 177:457.
47. Rapoport, M. J., Jaramillo, A., Zipris, D., Lazarus, A., Serreze, D. V., Leiter, E. H., Cyopick, P., Danska, J. S. and Delovitch, T. L. 1993. Interleukin-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:87.
48. + T-Cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34.
49. Segal, B. M., Dwyer, B. K. and Shevach, E. M. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187:537.
50. h2) responses to pancreatic islet autoantigens. J. Exp. Med. 186:2039.
51. Wu, B., Deng, C., Goluszko, E. and Christadoss, P. 1997. Tolerance to a dominant T cell epitope in the acetylcholine receptor molecule induces epitope spread and suppresses murine myasthenia gravis. J. Immunol. 159:3016.