Cross-resistance to ionizing radiation in a murine leukemic cell line resistant to cis-dichlorodiammineplatinum(II): Role of Ku autoantigen

Molecular Pharmacology

Volumn 56, Issue 1, 1999, Pages 141-146

  Frit, Philippe ^a   Canitrot, Yvan ^a   Muller, Catherine ^a   Foray, Nicolas ^b   Calsou, Patrick ^a   Marangoni, Elisabetta ^b   Bourhis, Jean ^b   Salles, Bernard ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; CROSS RESISTANCE; DNA BINDING; DRUG RESISTANCE; ELECTROPHORETIC MOBILITY; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IONIZING RADIATION; LEUKEMIA CELL; LEUKEMIA L 1210; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL;

EID: 0033060948     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.1.141     Document Type: Article

References (43)

1. Anderson CW, Connelly MA, Lees-Miller SP, Lintott LG, Zhang H, Sipley JA, Sakaguchi K and Appelle E (1995) The human DNA-activated kinase, DNA-PK: Substrate specificity, in Methods in Protein Structure Analysis (Atassi MZ and Appella E eds) pp 395-406, Plenum Press, New York.
2. Bessho T, Mu D and Sancar A (1997) Initiation of DNA interstrand cross-link repair in humans: The nucleotide excision repair system makes dual incisions 5′ to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand. Mol Cell Biol 17:6822-6830.
3. Blier PR, Griffith AJ, Craft J and Hardin JA (1993) Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J Biol Chem 268:7594-7601.
4. Bradford MN (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Caldecott K and Jeggo PA (1991) Cross-sensitivity of γ-ray-sensitive hamster mutants to cross-linking agents. Mutat Res 255:111-121.
6. Calsou P, Barret JM, Cros S and Salles B (1993) DNA excision repair synthesis is enhanced in a murine leukemia L1210 cell line resistant to cisplatin. Eur J Biochem 211:403-409.
7. Canitrot Y, Frit P and Salles B (1997) Deficient apoptotic process in cisplatin-resistant L1210 cells cannot account for the cellular response to various drug treatments. Biochem Biophys Res Commun 234:573-577.
8. Chaney SG and Sancar A (1996) DNA repair: Enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 88:1346-1360
9. Christodoulopoulos G, Muller C, Salles B, Kazmi R and Panasci L (1998) Potentiation of chlorambucil cytotoxicity in B-Cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin. Cancer Res 58:1789-1792.
10. Coughlin CT and Richmond RC (1989) Biologic and clinical developments of cisplatin combined with radiation: Concepts, utility, projection for news trials, and the emergence of carboplatin. Semin Oncol 16:31-43.
11. De Pooter CM, Scalliet PG, Elst HJ, Huybreschts JJ, Gheuens EE, Van Oosterom AT, Fichtinger-Schepman AM and De Bruijn EA (1991) Resistance patterns between cis-diamminedichloroplatinium(II) and ionizing radiation. Cancer Res 51: 4523-4527.
12. Falzon M, Fewell JW and Kuff EL (1993) EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J Biol Chem 268:10546-10552.
13. Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA and Jackson SP (1995) DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci USA 92:320-324.
14. Foray N, Badie C, Alsbeih G, Fertil B and Malaise EP (1996) A new model describing the curves for repair of both double-strand breaks and chromosome damage. Radiat Res 146:53-60.
15. Foray N, Priestley A, Alsbeih G, Badie C, Capulas EP, Arlett CF and Malaise EP (1997) Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int J Radiat Biol 72:271-283.
16. Francoeur AM, Peebles EM, Gompper PT and Tan EM (1986) Identification of Ki (Ku, p70/p80) autoantigens and analysis of anti-Ki autoantibody reactivity. J Immunol 136:1648-1653.
17. Geran RI, Greenberg NH, McDonald MM, Schumacher AM and Abott BJ (1972) Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep 3:1-52.
18. Gottlieb TM and Jackson SP (1993) The DNA dependent-protein kinase: Requirement for DNA ends and association with Ku antigen. Cell 72:131-142.
19. Henkels KM and Turchi JJ (1997) Induction of apoptosis in cisplatin-sensitive and-resistant human ovarian cell lines. Cancer Res 57:4488-4492.
20. Hill BT (1991) Interactions between antitumor agents and radiation and the expression of resistance. Cancer Treat Rev 18:149-190.
21. Jeggo PA (1997) DNA-PK: At the cross-roads of biochemistry and genetics. Mutat Res DNA Repair 384:1-14.
22. Lee SE, Pulaski CR, He DM, Benjamin DM, Voss M, Um J and Hendrickson EA (1995) Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination. Mutat Res 336:279-291.
23. Manley JL, Fire A, Samuels M and Sharp PA In vitro transcription: Whole-cell extract. Methods Enzymol 101:568-582 (1983).
24. Muller C, Calsou P, Frit P, Cayrol C, Carter T and Salles B (1998a) UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells. Nucleic Acids Res 26:1382-1389.
25. Muller C, Christodoulopoulos G, Salles B and Panasci L (1998b) The activivity of the DNA dependent protein kinase correlates with in vivo and in vitro sensitivity of chronic lymphocytic leukemia (CLL) lymphocytes to nitrogen mustards. Blood 92:2213-2219.
26. Muller C, Dusseau C, Calsou P and Salles B (1998c) Human normal peripheral blood B-lymphocytes are deficient in DNA-dependent protein kinase activity due to the expression of a variant form of the Ku86 protein. Oncogene 16:1553-1560.
27. Muller C and Salles B (1997) Regulation of DNA-dependent protein kinase activity in leukemic cells. Oncogene 15:2343-2348.
28. Nussenzweig A, Chen C, Da Costa-Soares V, Sanchez M, Sokol K, Nussenzweig MC and Li GC (1996) Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature (Lond) 382:551-555.
29. Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon CC, Li WH, Cheong N, Nussenzweig M, Iliakis G, Chen DJ and Li GC (1997) Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo. J Exp Med 186:921-929.
30. Peterson SR, Kurimasa A, Oshimura M, Dynan WS, Bradbury EM and Chen DJ (1995) Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci USA 92:3171-3174.
31. Quinn JP, Simpson J and Farina AR (1992) The Ku complex is modulated in response to viral infection and other cellular changes. Biochim Biophys Acta 1131:181-187.
32. Ramsden DA and Gellert M (1998) Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks. EMBO J 17:609-614.
33. Satoh M, Wang JS and Reeves WH (1995) Role of free p70 (Ku) subunit in post-translational stabilization of newly synthesized p80 during DNA-dependent protein kinase assembly. Eur J Cell Biol 66:127-135.
34. Schwartz, JL, Rotmensch J, Beckett MA, Jaffe DR, Toohill M, Giovanizzi SM, McIntosh J and Weichselbaum RR (1988) X-ray and cisdiamminedichloroplatinium(II) cross-resistance in human tumor cell lines. Cancer Res 48:3355-3359.
35. Singleton BK, Priestley A, Steingrimsdottir H, Cell D, Blunt T, Jackson SP, Lehmann AR and Jeggo PA (1997) Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol Cell Biol 17:1264-1273.
36. Smider V, Rathmell WK, Lieber MR and Chu G (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science (Wash DC) 266:288-291.
37. Taccioli GE, Cheng HL, Varghese AJ, Whitmore G and Alt FW (1994) A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation. J Biol Chem 269:7439-7442.
38. Tanaka T, Yamagami T, Oka Y, Nomura T and Sugiyama H (1993) The acid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links. Mutat Res 288:277-280 (1993).
39. Wallner KE and Li GC (1987) Effect of ciaplatin resistance on cellular radiation response. Int J Radiat Oncol Biol Phys 13:587-591.
40. Wood RD, Robins P and Lindahl T (1988) Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell 53:97-106.
41. Wu X and Lieber MR (1996) Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol Cell Biol 16:5186-5193.
42. Zhang WW and Yaneva M (1992) On the mechanisms of Ku protein binding to DNA. Biochem Biophys Res Commun 186:574-579.
43. Zhu C, Bogue MA, Lim DS, Hasty P and Roth DB (1996) Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86:379-389.