Synthesis and evaluation of 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine mono- and diesters as potential prodrugs of penciclovir

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 3, 1999, Pages 565-570

  Kim, Dae Kee ^a   Lee, Namkyu ^a   Kim, Hun Taek ^a   Im, Guang Jin ^a   Kim, Key H ^a  

^a SK Chemicals   (South Korea)

Author keywords

Antivirals; Chemotherapy; Enzyme inhibitors; Nucleosides

Indexed keywords

2 AMINO 6 FLUORO 9 (4 HYDROXY 3 HYDROXYMETHYLBUT 1 YL)PURINE DERIVATIVE; FAMCICLOVIR; PENCICLOVIR; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG SYNTHESIS; ESTERIFICATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; RAT;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; ESTERS; MOLECULAR STRUCTURE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SPECTRUM ANALYSIS;

EID: 0033053325     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00263-6     Document Type: Article

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