Synthesis and evaluation of 2-amino-9-(3-hydroxymethyl-4- alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir

Journal of Medicinal Chemistry

Volumn 41, Issue 18, 1998, Pages 3435-3441

  Kim, Dae Kee ^a   Lee, Namkyu ^a   Kim, Young Woo ^a   Chang, Kieyoung ^a   Kim, Jae Sun ^a   Im, Guang Jin ^a   Choi, Won Son ^a   Jung, Inho ^a   Kim, Taek Soo ^a   Hwang, Yong Youn ^a   Min, Dong Sun ^a   Um, Key An ^a   Cho, Yong Baik ^a   Kim, Key H ^a  

^a SK Chemicals   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 9 (3 HYDROXYMETHYL 4 ISOPROPOXYCARBONYLOXYBUT 1 YL)PURINE; 2 AMINO 9 [2 (2 OXO 1,3 DIOXAN 5 YL)ETHYL]PURINE; ACICLOVIR; ACYCLIC NUCLEOSIDE; BUCICLOVIR; GANCICLOVIR; PENCICLOVIR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG PURIFICATION; DRUG STABILITY; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; MALE; NONHUMAN; RAT; REACTION ANALYSIS; VIRUS INHIBITION; VIRUS REPLICATION;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE, TRANSFORMED; CERCOPITHECUS AETHIOPS; DRUG STABILITY; HERPESVIRUS 1, HUMAN; MALE; MICE; PRODRUGS; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; VERO CELLS; VIRUS REPLICATION;

EID: 15144355782     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980138g     Document Type: Article

References (22)

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