Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 12, 1998, Pages 2525-2530

  Kim, Dae Kee ^a   Lee, Namkyu ^a   Im, Guang Jin ^a   Kim, Hun Taek ^a   Kim, Key H ^a  

^a SK Chemicals   (South Korea)

Author keywords

Antivirals; Chemotherapy; Enzyme inhibitors; Nucleosides

Indexed keywords

2 AMINO 6 FLUORO 9 (2 ISOBUTYRYLOXYETHOXYMETHYL)PURINE; ACICLOVIR; ANTIVIRUS AGENT; PRODRUG; PURINE DERIVATIVE; UNCLASSIFIED DRUG; VALACICLOVIR;

ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG SOLUBILITY; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; IN VITRO STUDY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REACTION ANALYSIS;

HUMAN HERPESVIRUS 1;

EID: 0032436343     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)80026-6     Document Type: Article

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