Synthesis and evaluation of amino acid esters of 6-deoxypenciclovir as potential prodrugs of penciclovir

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 2, 1999, Pages 419-424

  Kim, Dae Kee ^a   Lee, Namkyu ^a   Kim, Young Woo ^a   Chang, Kieyoung ^a   Im, Guang Jin ^a   Choi, Won Son ^a   Kim, Key H ^a  

^a Sunkyong Industries   (South Korea)

Author keywords

Antivirals; Chemotherapy; Enzyme inhibitors; Nucleosides

Indexed keywords

6 DEOXYPENCICLOVIR O ISOLEUCINATE; 6 DEOXYPENCICLOVIR O VALINATE; 6 DEOXYPENCICLOVIR O,O DIGLYCINATE; AMINO ACID; ANTIVIRUS AGENT; PENCICLOVIR; PENCICLOVIR DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG EXCRETION; DRUG SYNTHESIS; DRUG TRANSFORMATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RAT; REACTION ANALYSIS;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MODELS, CHEMICAL; RATS; SPECTROPHOTOMETRY;

EID: 0033051827     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00235-1     Document Type: Article

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