Synthesis and evaluation of amino acid ester prodrugs of penciclovir

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 15, 1996, Pages 1849-1854

  Kim, Dae Kee ^a   Lee, Namkyu ^a   Im, Guang Jin ^a   Kim, Young Woo ^a   Chang, Kieyoung ^a   Kim, Hun Taek ^a   Cho, Yong Baik ^a   Choi, Won Son ^a   Jung, Inho ^a   Kim, Key H ^a  

^a Sunkyong Industries   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; FAMCICLOVIR; O ACETYL O VALYLPENCICLOVIR; PENCICLOVIR; PENCICLOVIR DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; VERO CELL;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030572498     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00329-0     Document Type: Article

References (14)

1. 1. Harnden, M. R.; Jarvest, R. L.; Bacon, T. H.; Boyd, M. R. J. Med. Chem. 1987, 30, 1636-1642.
2. 2. Boyd, M. R.; Bacon, T. H.; Sutton, D.; Cole, M. Antimicrob. Agents Chemother. 1987, 31, 1238-1242.
3. 3. Boyd, M. R.; Safrin, S.; Kern, E. R. Antiviral Chem. Chemother. 1993, 4 (Suppl. 1), 3-11.
4. 4. Bacon, T. H.; Schinazi, R. F. Antiviral Chem. Chemother. 1993, 4 (Suppl. 1), 25-36.
5. 5. de Miranda, P.; Krasny, H. C; Page, D. A.; Elion, G. B. J. Pharmacol. Exp. Ther. 1981, 219, 309-315.
6. 6. Jacobson, M. A.; de Miranda, P.; Cederberg, D. M.; Burnett, T.; Cobb, E.; Brodie, H. R.; Mills, J. Antimicrob. Agents Chemother. 1987, 31, 1251-1254.
7. 7. Larsson, A.; Stenberg, K.; Ericson, A.-C; Haglund, U.; Yisak, W.-A.; Johansson, N. G.; Öberg, B.; Datema, R. Antimicrob. Agents Chemother. 1986,30, 598-605.
8. 8. Harnden, M. R.; Jarvest, R. L.; Boyd, M. R.; Sutton, D.; Vere Hodge, R. A. J. Med. Chem. 1989, 32, 1738-1743.
9. 9. Vere Hodge, R. A.; Sutton, D.; Boyd, M. R.; Harnden, M. R.; Jarvest, R. L. Antimicrob. Agents Chemother. 1989, 33, 1765-1773.
10. 10. Pue, M. A.; Benet, L. Z. Antiviral Chem. Chemother. 1993, 4 (Suppl. 1), 47-55.
11. 11. Beauchamp, L. M.; Orr, G. F.; de Miranda, P.; Burnett, T.; Krenitsky, T. A. Antiviral Chem. Chemother. 1992, 3, 157-164.
12. 12. Soul-Lawton, J.; Seaber, E.; On, N.; Wootton, R.; Rolan, P.; Posner, J. Antimicrob. Agents Chemother. 1995, 39, 2759-2764.
13. 13. Patent Cooperation Treaty (PCT) 1995, WO 95/09855.
14. 5: C, 47.39; H, 6.32; N, 19.50. Found: C, 47.16; H, 6.51; N, 19.42.