Modulation of P450-dependent ifosfamide pharmacokinetics: A better understanding of drug activation in vivo

British Journal of Cancer

Volumn 77, Issue 11, 1998, Pages 1768-1776

  Brain, E G C ^a   Yu, L J ^a   Gustafsson, K ^a   Drewes, P ^a   Waxman, D J ^a  

^a BOSTON UNIVERSITY   (United States)

Author keywords

Cytochrome P450; Ifosfamide; Neurotoxicity; Pharmacokinetics

Indexed keywords

CHLOROACETALDEHYDE; CYTOCHROME P450; IFOSFAMIDE; PHENOBARBITAL; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DRUG ACTIVATION; DRUG HALF LIFE; DRUG HYDROXYLATION; DRUG INACTIVATION; DRUG METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031779382     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.295     Document Type: Article

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