메뉴 건너뛰기




Volumn 19, Issue 2, 1999, Pages 290-297

Urokinase activates the Jak/Stat signal transduction pathway in human vascular endothelial cells

Author keywords

Endothelial cells; Jak Stat pathway; Signal transduction; Urokinase receptor

Indexed keywords

UROKINASE; UROKINASE RECEPTOR;

EID: 0033045293     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.2.290     Document Type: Article
Times cited : (57)

References (43)
  • 1
    • 1842407860 scopus 로고    scopus 로고
    • Vascular development: Cellular and molecular regulation
    • Beck L Jr, D'Amore PA. Vascular development: cellular and molecular regulation. FASEB J. 1997;11:365-373.
    • (1997) FASEB J. , vol.11 , pp. 365-373
    • Beck L., Jr.1    D'Amore, P.A.2
  • 2
    • 0030952477 scopus 로고    scopus 로고
    • Cytokine regulation of endothelial cell function: From molecular level to the bedside
    • Mantovani A, Bussolino F, Introna M. Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol Today. 1997;18:231-240.
    • (1997) Immunol Today , vol.18 , pp. 231-240
    • Mantovani, A.1    Bussolino, F.2    Introna, M.3
  • 3
    • 0028966599 scopus 로고
    • Vascular endothelium: An integrator of pathophysiologic stimuli in atherosclerosis
    • Gimbrone MA Jr. Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol. 1995;75:67B-70B.
    • (1995) Am J Cardiol. , vol.75
    • Gimbrone M.A., Jr.1
  • 4
    • 0026806895 scopus 로고
    • Migration of smooth muscle and endothelial cells: Critical events in restenosis
    • Casscells W. Migration of smooth muscle and endothelial cells: critical events in restenosis. Circulation. 1992;86:723-729.
    • (1992) Circulation , vol.86 , pp. 723-729
    • Casscells, W.1
  • 5
    • 0030944931 scopus 로고    scopus 로고
    • Integrins and vascular extracellular matrix assembly
    • Ruoslahti E, Engvall E. Integrins and vascular extracellular matrix assembly. J Clin Invest. 1997;99:1149-1152.
    • (1997) J Clin Invest. , vol.99 , pp. 1149-1152
    • Ruoslahti, E.1    Engvall, E.2
  • 6
    • 0030878409 scopus 로고    scopus 로고
    • Integrins signaling in vascular biology
    • Shattil SJ, Ginsberg MH. Integrins signaling in vascular biology. J Clin Invest. 1997;100:1-5.
    • (1997) J Clin Invest. , vol.100 , pp. 1-5
    • Shattil, S.J.1    Ginsberg, M.H.2
  • 7
    • 0023746649 scopus 로고
    • Membrane and matrix localization of proteases: A common theme in tumor invasion and angiogenesis
    • Moscatelli D, Rifkin DB. Membrane and matrix localization of proteases: a common theme in tumor invasion and angiogenesis. Biochim Biophys Acta. 1988;948:67-85.
    • (1988) Biochim Biophys Acta , vol.948 , pp. 67-85
    • Moscatelli, D.1    Rifkin, D.B.2
  • 8
    • 0025697078 scopus 로고
    • Proteolytic balance and capillary morphogenesis
    • Pepper MS, Montesano R. Proteolytic balance and capillary morphogenesis. Cell Differ Dev. 1991;32:319-328.
    • (1991) Cell Differ Dev. , vol.32 , pp. 319-328
    • Pepper, M.S.1    Montesano, R.2
  • 9
    • 0024146930 scopus 로고
    • Cell associated plasminogen activation: Regulation and physiological functions
    • Saskela O, Rifkin DB. Cell associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol. 1988;4:93-126.
    • (1988) Annu Rev Cell Biol. , vol.4 , pp. 93-126
    • Saskela, O.1    Rifkin, D.B.2
  • 10
    • 0025336879 scopus 로고
    • The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes
    • Estriecher A, Mühlhauser J, Carpentier J.-L, Orci L, Vassalli J-D. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol. 1990;111: 783-792.
    • (1990) J Cell Biol. , vol.111 , pp. 783-792
    • Estriecher, A.1    Mühlhauser, J.2    Carpentier, J.-L.3    Orci, L.4    Vassalli, J.-D.5
  • 12
    • 0028905522 scopus 로고
    • Migrating vascular smooth muscle cells polarize cell surface urokinase receptors after injury in vitro
    • Okada SS, Tomaszewski JE, Barnathan ES. Migrating vascular smooth muscle cells polarize cell surface urokinase receptors after injury in vitro. Exp Cell Res. 1995;217:180-187.
    • (1995) Exp Cell Res. , vol.217 , pp. 180-187
    • Okada, S.S.1    Tomaszewski, J.E.2    Barnathan, E.S.3
  • 14
    • 0030057694 scopus 로고    scopus 로고
    • Migration of arterial wall cells: Expression of plasminogen activators and inhibitors in injured rat arteries
    • Reidy MA, Irvin C, Lindner V. Migration of arterial wall cells: expression of plasminogen activators and inhibitors in injured rat arteries. Circ Res. 1996;78:405-414.
    • (1996) Circ Res. , vol.78 , pp. 405-414
    • Reidy, M.A.1    Irvin, C.2    Lindner, V.3
  • 16
    • 0028305433 scopus 로고
    • Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanism for signal transduction in human epithelial cells
    • Busso N, Masur SK, Lazeda D, Waxman S, Ossowski L. Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. J Cell Biol. 1994;128: 259-270.
    • (1994) J Cell Biol. , vol.128 , pp. 259-270
    • Busso, N.1    Masur, S.K.2    Lazeda, D.3    Waxman, S.4    Ossowski, L.5
  • 17
    • 0028294295 scopus 로고
    • Induction of c-fos gene by urokinase plasminogen activator in human ovarian cancer cells
    • Dumler I, Petri T, Schleuning W-D. Induction of c-fos gene by urokinase plasminogen activator in human ovarian cancer cells. FEBS Lett. 1994; 343:103-106.
    • (1994) FEBS Lett. , vol.343 , pp. 103-106
    • Dumler, I.1    Petri, T.2    Schleuning, W.-D.3
  • 18
    • 0028925552 scopus 로고
    • Urokinase plasminogen activator receptor, β2-integrins, and Src-kinases within a single receptor complex of human monocytes
    • Bohuslav J, Horejsi V, Hansmann C, Stöckl J, Weidle, UH, Majdic O, Bartke I, Knapp W, Stockinger H. Urokinase plasminogen activator receptor, β2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med. 1995;181:1381-1390.
    • (1995) J Exp Med. , vol.181 , pp. 1381-1390
    • Bohuslav, J.1    Horejsi, V.2    Hansmann, C.3    Stöckl, J.4    Majdic, O.5    Bartke, I.6    Knapp, W.7    Stockinger, H.8
  • 19
    • 0029923744 scopus 로고    scopus 로고
    • Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect
    • Resnati M, Guttinger M, Valcamonica S, Sidenius N, Blasi F, Fazioli F. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J. 1996;15:1572-1582.
    • (1996) EMBO J. , vol.15 , pp. 1572-1582
    • Resnati, M.1    Guttinger, M.2    Valcamonica, S.3    Sidenius, N.4    Blasi, F.5    Fazioli, F.6
  • 21
    • 0029873910 scopus 로고    scopus 로고
    • The urokinase receptor is a major vitronectin-binding protein on endothelial cells
    • Kanse SM, Kost C, Wilhelm OG, Andreasen PA, Preissner KT. The urokinase receptor is a major vitronectin-binding protein on endothelial cells. Exp Cell Res. 1996;224:344-353.
    • (1996) Exp Cell Res. , vol.224 , pp. 344-353
    • Kanse, S.M.1    Kost, C.2    Wilhelm, O.G.3    Andreasen, P.A.4    Preissner, K.T.5
  • 22
    • 0030757506 scopus 로고    scopus 로고
    • Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
    • Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest. 1997;100:58-67.
    • (1997) J Clin Invest. , vol.100 , pp. 58-67
    • Waltz, D.A.1    Natkin, L.R.2    Fujita, R.M.3    Wei, Y.4    Chapman, H.A.5
  • 23
    • 0029847191 scopus 로고    scopus 로고
    • Requirement of receptor-bound urokinase-type plasminogen activator for integrin avb5-directed cell migration
    • Yebra M, Parry CN, Strömblad S, Mackman N, Rosenberg S, Mueller BM, Cheresh DA. Requirement of receptor-bound urokinase-type plasminogen activator for integrin avb5-directed cell migration. J Biol Chem. 1996;271:29393-29399.
    • (1996) J Biol Chem. , vol.271 , pp. 29393-29399
    • Yebra, M.1    Parry, C.N.2    Strömblad, S.3    Mackman, N.4    Rosenberg, S.5    Mueller, B.M.6    Cheresh, D.A.7
  • 24
    • 0030718565 scopus 로고    scopus 로고
    • Signal transduction via urokinase receptor: Is a transmembrane adapter molecule really necessary?
    • Dumler I, Hucho F, Gulba D. Signal transduction via urokinase receptor: is a transmembrane adapter molecule really necessary? Fibrinolysis Proteolysis. 1997;11(suppl 2):165-169.
    • (1997) Fibrinolysis Proteolysis , vol.11 , Issue.2 SUPPL. , pp. 165-169
    • Dumler, I.1    Hucho, F.2    Gulba, D.3
  • 26
    • 0028359835 scopus 로고
    • JAK protein tyrosine kinases: Their role in cytokine signalling
    • Ziemiecki A, Harpur AG, Wilks AF. JAK protein tyrosine kinases: their role in cytokine signalling. Trends Cell Biol. 1994;4:207-212.
    • (1994) Trends Cell Biol. , vol.4 , pp. 207-212
    • Ziemiecki, A.1    Harpur, A.G.2    Wilks, A.F.3
  • 28
    • 0030962017 scopus 로고    scopus 로고
    • The state of the STATs: Recent developments in the study of signal transduction to the nucleus
    • Horvath CM, Darnell JE Jr. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr Opin Cell Biol. 1997;9:233-239.
    • (1997) Curr Opin Cell Biol. , vol.9 , pp. 233-239
    • Horvath, C.M.1    Darnell J.E., Jr.2
  • 29
    • 0030042198 scopus 로고    scopus 로고
    • PDGF receptor-to-nucleus signaling of p91 (STAT1a) transcription factor in rat smooth muscle cells
    • Yamamoto H, Crow M, Cheung L, Lakatta E, Kinsella J. PDGF receptor-to-nucleus signaling of p91 (STAT1a) transcription factor in rat smooth muscle cells. Exp Cell Res. 1996;222:125-130.
    • (1996) Exp Cell Res. , vol.222 , pp. 125-130
    • Yamamoto, H.1    Crow, M.2    Cheung, L.3    Lakatta, E.4    Kinsella, J.5
  • 30
    • 0030936627 scopus 로고    scopus 로고
    • GAS elements: A few nucleotides with a major impact on cytokine-induced gene expression
    • Decker T, Kovarik P, Meinke A. GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J Interferon Cytokine Res. 1997;17:121-134.
    • (1997) J Interferon Cytokine Res. , vol.17 , pp. 121-134
    • Decker, T.1    Kovarik, P.2    Meinke, A.3
  • 31
    • 0030716909 scopus 로고    scopus 로고
    • Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598
    • Koshelnick Y, Ehart M, Hufnagl P, Heinrich PC, Binder BR. Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598. J Biol Chem. 1997;272:28563-28567.
    • (1997) J Biol Chem. , vol.272 , pp. 28563-28567
    • Koshelnick, Y.1    Ehart, M.2    Hufnagl, P.3    Heinrich, P.C.4    Binder, B.R.5
  • 32
    • 0031983177 scopus 로고    scopus 로고
    • The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells
    • Dumler I, Weis A, Mayboroda OA, Maasch C, Jerke U, Haller H, Gulba DC. The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem. 1998;273:315-321.
    • (1998) J Biol Chem. , vol.273 , pp. 315-321
    • Dumler, I.1    Weis, A.2    Mayboroda, O.A.3    Maasch, C.4    Jerke, U.5    Haller, H.6    Gulba, D.C.7
  • 33
    • 0029791664 scopus 로고    scopus 로고
    • Unique signal transduction of Eyk: Constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase
    • Zong C, Yan R, August A, Darnell JE, Hanafusa H. Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J. 1996;15:4515-4525.
    • (1996) EMBO J. , vol.15 , pp. 4515-4525
    • Zong, C.1    Yan, R.2    August, A.3    Darnell, J.E.4    Hanafusa, H.5
  • 34
    • 0030696081 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes
    • Kodama H, Fukuda K, Pan J, Makino S, Baba A, Hori S, Ogawa S. Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes. Circ Res. 1997;81:656-663.
    • (1997) Circ Res. , vol.81 , pp. 656-663
    • Kodama, H.1    Fukuda, K.2    Pan, J.3    Makino, S.4    Baba, A.5    Hori, S.6    Ogawa, S.7
  • 36
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle JN. STATs: signal transducers and activators of transcription. Cell. 1996;84:331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 37
    • 0030587087 scopus 로고    scopus 로고
    • Delayed tyrosine phosphorylation and nuclear expression of Stat1 following antigen receptor stimulation of B lymphocytes
    • Karras JG, Huo L, Wang Z, Frank DA, Zimmet JM, Rothstein TL. Delayed tyrosine phosphorylation and nuclear expression of Stat1 following antigen receptor stimulation of B lymphocytes. J Immunol. 1996; 157:2299-2309.
    • (1996) J Immunol. , vol.157 , pp. 2299-2309
    • Karras, J.G.1    Huo, L.2    Wang, Z.3    Frank, D.A.4    Zimmet, J.M.5    Rothstein, T.L.6
  • 39
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su WCS, Kitawaga M, Xue N, Xie B, Garofalo S, Cho J, Deng C, Horton WA, Fu XY. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature. 1997;386: 288-292.
    • (1997) Nature , vol.386 , pp. 288-292
    • Su, W.C.S.1    Kitawaga, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6    Deng, C.7    Horton, W.A.8    Fu, X.Y.9
  • 40
    • 0029738371 scopus 로고    scopus 로고
    • Interferon-γ-mediated activation of Stat1a regulates growth factor-induced mitogenesis
    • Marra F, Choudhury GG, Abboud HE. Interferon-γ-mediated activation of Stat1a regulates growth factor-induced mitogenesis. J Clin Invest. 1996;98:1218-1230.
    • (1996) J Clin Invest. , vol.98 , pp. 1218-1230
    • Marra, F.1    Choudhury, G.G.2    Abboud, H.E.3
  • 41
    • 0030026354 scopus 로고    scopus 로고
    • Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and Stat1a
    • Singh K, Balligand JL, Fischer T, Smith TW, Kelly RA. Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and Stat1a. J Biol Chem. 1996;271: 1111-1117.
    • (1996) J Biol Chem. , vol.271 , pp. 1111-1117
    • Singh, K.1    Balligand, J.L.2    Fischer, T.3    Smith, T.W.4    Kelly, R.A.5
  • 42
    • 0031281444 scopus 로고    scopus 로고
    • Molecular mechanisms of angiotensin II in modulating cardiac function: Intracardiac effects and signal transduction pathways
    • Dostal DE, Hunt RA, Kule CE, Bhat GJ, Karoor V, McWhinney CD, Baker KM. Molecular mechanisms of angiotensin II in modulating cardiac function: intracardiac effects and signal transduction pathways. J Mol Cell Cardiol. 1997;29:2893-2902.
    • (1997) J Mol Cell Cardiol. , vol.29 , pp. 2893-2902
    • Dostal, D.E.1    Hunt, R.A.2    Kule, C.E.3    Bhat, G.J.4    Karoor, V.5    McWhinney, C.D.6    Baker, K.M.7
  • 43
    • 0030774561 scopus 로고    scopus 로고
    • Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation
    • Marrero MB, Schieffer B, Li B, Sun J, Harp JB, Ling BN. Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J Biol Chem. 1997;272:24684-24690.
    • (1997) J Biol Chem. , vol.272 , pp. 24684-24690
    • Marrero, M.B.1    Schieffer, B.2    Li, B.3    Sun, J.4    Harp, J.B.5    Ling, B.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.