AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines

Molecular Medicine

Volumn 2, Issue 3, 1996, Pages 358-366

  Nuovo, Gerard J ^a   Alfieri, Maria Lynn ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; ASTROCYTE; CHILD; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN SITU HYBRIDIZATION; MICROGLIA; NERVE CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS REPLICATION;

EID: 0029833018     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401633     Document Type: Article

References (21)

1. Price RW, Brew B, Sidti J, Rosenblum M, Scheck AC, Cleary P. (1988) The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex. Science 239:586-592.
2. Grant I, Atkinson JH, Hesselink JR. (1987) Evidence for early central nervous system involvement in acquired immunodeficiency syndrome and other human immunodeficiency virus infections. Ann. Intern. Med. 107: 828-836.
3. Weiser B, LaNeve D, Eilbott DJ, Seidman R, Burger H. (1990) Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease. Proc. Natl. Acad. Sci. U.S.A. 87: 3997-4001.
4. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA. (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc. Natl. Acad. Sci. U.S.A. 83:7089-7093.
5. Tornatore C, Nath A, Amemiya K, Major EO. (1990) Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumore necrosis factor alpha and interleukin-1 beta. J. Virol. 65:6094-6100.
6. Watkins B, Dorn H, Kelley H, et al. (1990) Specific tropism of HIV-1 for microglial cells in primary human brain cultures. Science 249:549-553.
7. Cvetkovich TA, Lazar E, Blumberg BM, et al. (1992) Human immunodeficiency virus type 1 infection of neural xenografts. Proc. Natl. Acad. Sci. U.S.A. 89:5162-5166.
8. Harouse JM, Bhat S, Spitalnik SL, et al. (1991) Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide. Science 253:320-322.
9. Nuovo GJ, Gallery F, MacConnell P, Braun A. (1994) In situ detection of PCR-amplified HIV-1 nucleic acids and tumor necrosis factor RNA in the central nervous system. Am. J. Pathol. 144:659-666.
10. Lipton SA. (1991) HIV-1 related neurotoxicity. Brain Pathol. 1:193-199.
11. Yamada M, Zurbriggen A, Oldstone M, Fujinami R. (1991) Common immunologic determinant between human immunodeficiency virus type 1 gp41 and astrocytes. J. Virol. 65:1370-1376.
12. Dubrovsky L, Ulrich P, Nuovo GJ, Manogue KR, Cerami A, Burkinsky M. (1995) Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. Mol. Med. 1:217-230.
13. Schmidtmayerova H, Notte HS, Nuovo GJ, et al. (in press) HIV-1 infection alters chemokine β peptide expression in human monocytes: Implications for recruitment of leukocytes into brain and lymph nodes. Proc. Natl. Acad. Sci. U.S.A. (In press).
14. Nuovo GJ. (1994) PCR in Situ Hybridization: Protocols and Applications. 2nd Ed., Raven Press, New York.
15. Nuovo GJ, Becker J, Margiotta M, Burke M, Fuhrer J, Steigbigel R. (1994) In situ detection of PCR-amplified HIV-1 nucleic acids in lymph nodes and peripheral blood in asymptomatic infection and advanced stage AIDS. J. Acquir. Immune Defic. 7:916-923.
16. Bagasra O, Hauptman SP, Lischer HW, Sachs M, Pomerantz RJ. (1992) Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N. Engl. J. Med. 326:1385-1391.
17. Nuovo GJ, Forde A. (1995) An improved system for reverse transcriptase in situ PCR. J. Histotech. 18:295-299.
18. Seshamma P, Bagasra O, Oakes J, Pomerantz RJ. (1992) Quantitative RT PCR for HIV-1 RNA specific species. J. Virol. Methods 40:331-346.
19. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. (1991) Nitic oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88:6368-6371.
20. Buttery LDK, Evans TJ, Cohen J, Polak JM. (1994) Immunohistochemical localization of inducible nitric oxide synthetase in endotoxin treated rats. Lab. Invest. 71:755-764.
21. Huang Z, Huang PL, Dalkara T, Fishman MC, Moskowitz MA. (1994) Effect of cerebral ischemia in mice deficient in neuronla nitic oxide synthetase. Science 265:1883-1885.