Differential uptake of myo-inositol in vivo into rat brain areas

European Neuropsychopharmacology

Volumn 6, Issue 1, 1996, Pages 73-75

  Patishi, Yardena ^a   Lubrich, Beate ^b   Berger, Mathias ^b   Kofman, Ora ^a   Van Calker, Dietrich ^b   Belmaker, R H ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Brain areas; Inositol; Uptake

Indexed keywords

INOSITOL; LITHIUM;

ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; BRAIN TISSUE; IN VIVO STUDY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0029936721     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0924-977X(95)00061-S     Document Type: Article

References (19)

1. Agam, G., Shapiro, J., Bersudsky, Y., Kofman, O. and Belmaker, R.H. (1994) Effect of high-dose peripheral inositol: brain inositol levels and prevention of behavioral changes due to inositol depletion. Pharmacol. Biochem. Behav. 49, 341-343.
2. + as secondary, selective, consequences of inositol depletion in 1321 N1 cells. Biochem. J. 297, 529-537.
3. Batty, I.H., Michie, A., Fennel, M. and Downes, C.P. (1993) The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. Biochem. J. 294, 49-55.
4. Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D. and Belmaker, R.H. (1995) Inositol treatment for panic disorder: a double-blind placebo-controlled crossover trial. Am. J. Psychiatry (in press).
5. Bersudsky, Y., Mahler, O., Kofman, O. and Belmaker, R.H. (1994) Species differences in susceptibility to Li-pilocarpine seizures. Eur. Neuropsychopharmacol. 4, 429-430.
6. Hirvonen, M.R. and Savoluinen, K. (1991) Lithium-induced decrease of brain inositol and increase of brain inositol-1-phosphate is transient. Neurochem. Res. 16, 905-911.
7. Jenkinson, S., Patel, N., Nahorski, S.R. and Challiss, R.A.J. (1993) Comparative effects of lithium on the phosphoinositide cycle in rat cerebral cortex, hippocampus and striatum. J. Neurochem, 61, 1082-1090.
8. Kofman, O. and Belmaker, R.H. (1990) Intracerebroventricular myo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats. Brain Res. 534, 345-347.
9. Kofman, O. and Belmaker, R.H. (1993) Biochemical, behavioral and clinical studies of the role of inositol in lithium treatment and depression. Biol. Psychiatry 34, 839-852.
10. Lee, C.H., Dixon, J.F., Reichman, M., Moummi, C., Los, G. and Hokin, L.E. (1992) Li increases accumulation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. Biochem. J. 282, 377-385.
11. Levine, J., Rapaport, A., Lev, L., Bersudsky, Y., Kofman, O., Belmaker, R.H., Shapiro, J. and Agam, G. (1993) Inositol treatment raises CSF inositol levels. Brain Res. 627, 168-170.
12. Levine, J., Barak, Y., Gonsalves, M., Szor, H., Elizur, A., Kofman, O. and Belmaker, R.H. (1995) A double-blind controlled trial of inositol treatment of depression. Am. J. Psychiatry 152, 792-794.
13. Paredes, A., McManus, M., Kwon, H.M. and Strange, K. (1992) Osmoregulation of NA -inositol cotransporter activity and mRNA levels in brain glial cells. Am. J. Physiol. 263, 1282-1288.
14. Prpi, V. Blackmore, P.F. and Exton, J.H. (1982) Myo-inositol uptake and metabolism in isolated rat liver cells. J. Biol. Chem. 257, 11315-11322.
15. 2) receptor induced homologous and heterologous desensitization. Brain Res. 631, 349-351.
16. Sherman, W.R., Munsell, L.Y., Gish, B.G. and Honchar, M.P. (1985) Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney and testis. J. Neurochem. 44, 798-807.
17. Spector, R. (1976) The specificity and sulfhydryl sensitivity of the inositol transport system of the central nervous system. J. Neurochem. 27, 229-236.
18. Spector, R. and Lorenzo, A.V. (1975) Myo-inositol transport in the central nervous system. Am. J. Physiol. 288, 1510-1518.
19. Yamauchi, A., Nakanishi, T., Takamitsu, Y., Sugita, M., Imai. F., Noguchi, T., Fujiwara. Y., Kamada, T. and Ueda, N. (1994) In vivo osmoregulation of Na/myo-inositol cotransporter mRNA in rat kidney medulla. J. Am. Soc. Nephrol. 5, 62-67.