The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs

Infection and Immunity

Volumn 67, Issue 4, 1999, Pages 1659-1665

  Segal, Brahm H ^a   Doherty, T Mark ^a   Wynn, Thomas A ^a   Cheever, Allen W ^a   Sher, Alan ^a   Holland, Steven M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; GENE PRODUCT; INTERLEUKIN 4; INTERLEUKIN 5; PARASITE ANTIGEN; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; KNOCKOUT MOUSE; LUNG GRANULOMA; MONONUCLEAR CELL; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SPLEEN CELL; WORM EGG;

EID: 0033034095     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.4.1659-1665.1999     Document Type: Article

References (37)

1. Appelberg, R., A. G. Castro, J. Pedrosa, R. A. Silva, I. M. Orme, and P. Minoprio. 1994. Role of gamma Interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection. Infect. Immun. 62:3962-3971. (Erratum, 63:1145, 1995.)
2. 4) on BALB/c mice splenocyte production of Th1 and Th2 lymphokines. J. Immunopharmacol. 17:457-463.
3. 2: senescence-like growth arrest or apoptosis? Cell Growth. Differ. 8:589-598.
4. phox-/- mice: implications for fungal pathogenicity and host defense in chronic granulomatous disease. J. Clin. Investig. 101:1843-1850.
5. Cheever, A. W., M. E. Williams, T. A. Wynn, F. D. Finkelman, R. A. Seder, T. M. Cox, S. Hieny, P. Caspar, and A. Sher. 1994. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J. Immunol. 153:753-759.
6. Chin, T. W., E. R. Stiehm, J. Falloon, and J. I. Gallin. 1987. Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease. J. Pediatr. 111:349-352.
7. Clark, R. A., and S. J. Klebanoff. 1979. Chemotactic factor inactivation by the myeloperoxidase-hydrogen peroxide-halide system. J. Clin. Investig. 64: 913-920.
8. Coxon, A., P. Rieu, F. J. Barkalow, S. Askari, A. H. Sharpe, U. H. Von Andrian, M. A. Arnaout, and T. N. Mayadas. 1996. A novel role for the B2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5:653-666.
9. Doherty, T. M., and A. Sher. 1997. Defects in cell-mediated immunity after chronic, but not innate, resistance of mice to Mycobacterium avium infection. J. Immunol. 158:4822-4831.
10. Fang, W., K. A. Nath, M. F. Mackey, R. J. Noelle, D. L. Mueller, and T. W. Behrens. 1997. CD40 inhibits B cell apoptosis by upregulating bcl-xL expression and blocking oxidant accumulation. Am. J. Physiol. 272:C950-C956.
11. Gallin, J. I., and E. S. Buescher. 1983. Abnormal regulation of inflammatory skin responses in male patients with chronic granulomatous disease. Inflammation 7:227-232.
12. Gallin, J. I., E. S. Buescher, B. E. Seligmann, J. Nath, T. Gaither, and P. Katz. 1983. NIH conference. Recent advances in chronic granulomatous disease. Ann. Intern. Med. 99:657-674.
13. Gallin, J. I., J. M. Farber, S. M. Holland, and T. B. Nutman. 1995. Interferon-γ in the management of infectious diseases. Ann. Intern. Med. 123: 216-224.
14. Gao, J. L., T. A. Wynn, Y. Chang, E. J. Lee, H. E. Broxmeyer, S. Cooper, H. L. Tiffany, H. Westphal, K. J. Kwon-Chung, and P. M. Murphy. 1997. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185:1959-1968.
15. 4 via NADPH oxidase-dependent mechanism. Eur. J. Clin. Investig. 19:404-411.
16. + T cells. Int. Immunol. 8:1299-1310.
17. Henderson, W. R., and S. J. Klebanoff. 1983. Leukotriene production and inactivation by normal, chronic granulomatous disease and myeloperoxidase-deficient neutrophils. J. Biol. Chem. 258:13522-13527.
18. Iwata, S., T. Hori, N. Sato, K. Hirota, T. Sasada, A. Mitsui, T. Hirakawa, and J. Yodoi. 1997. Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state. J. Immunol. 158:3108-3117.
19. phox mouse knock-out model of chronic granulomatous disease. J. Exp. Med. 182:751-758.
20. Metzger, Z., J. T. Hoffeld, and J. J. Oppenheim. 1980. Macrophage-mediated suppression. I. Evidence for participation of both hydrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation. J. Immunol. 124:983-988.
21. 4 involvement in cutaneous leishmaniasis: relation with infection status and cytokine production. Parasitology 112:13-19.
22. Morgenstern, D. E., M. A. Gifford, L. L. Li, C. M. Doerschuk, and M. C. Dinauer. 1997. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J. Exp. Med. 185:207-218.
23. Pollock, J. D., D. A. Williams, M. A. C. Gifford, L. L. Li, X. Du, J. Fisherman, S. H. Orkin, C. M. Doerschuk, and M. C. Dinauer. 1995. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat. Genet. 9:202-209.
24. Rola-Pleszczynski, M., and I. Lemaire. 1985. Leukotrienes augment interleukin 1 production by human monocytes. J. Immunol. 135:1358-1361.
25. 4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and postranscriptional mechanisms. Blood 80:1004-1111.
26. Sandstrom, P. A., M. D. Mannie, and T. M. Buttke. 1994. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J. Leukoc. Biol. 55:221-226.
27. Sarmento, A., and R. Appelberg. 1996. Involvement of reactive oxygen intermediates in tumor necrosis factor alpha-dependent bacteriostasis of Mycobacterium avium. Infect. Immun. 64:3224-3230.
28. Segal, A. W., M. Geisow, R. Garcia, A. Harper, and R. Miller. 1981. The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature 290:406-409.
29. 4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 86:453-460.
30. Szabo, C. 1996. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radic. Biol. Med. 21:855-869.
31. Watson, R. W., O. D. Rotstein, A. B. Nathens, A. P. Dackiw, and J. C. Marshall. 1996. Thiol-mediated redox regulation of neutrophil apoptosis. Surgery 120:150-157.
32. Wynn, T. A., and A. W. Cheever. 1995. Cytokine regulation of granuloma formation in schistosomiasis. Curr. Opin. Immunol. 7:505-511.
33. Wynn, T. A., A. W. Cheever, D. Jankovic, R. W. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594-596.
34. Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 179:1551-1561.
35. Wynn, T. A., D. Jankovic, S. Hieny, A. W. Cheever, and A. Sher. 1995. IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression. IgE production, and tissue cosinophilia. J. Immunol. 154:4701-4709.
36. Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma. J. Immunol. 154:3999-4009.
37. Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Hieny, D. Jankovic, M. Strand, and A. Sher. 1996 IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068-4078.