The effects of aerosolized dextran in a mouse model of Pseudomonas aeruginosa pulmonary infection

Journal of Infectious Diseases

Volumn 179, Issue 6, 1999, Pages 1449-1458

  Bryan, Ruth ^a,b   Feldman, Matthew ^a,b   Jawetz, Sheryl C ^a,b   Rajan, Sujatha ^a,b   DiMango, Emily ^a,b   Tang, H Babette ^a,b   Scheffler, Lee ^a,b   Speert, David P ^a,b   Prince, Alice ^a,b,c  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ARABINOGALACTAN; DEXTRAN; INTERLEUKIN 8; MALTOSE; MANNAN; MELIBIOSE; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; RAFFINOSE; TREHALOSE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIUM ADHERENCE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSTIMULATION; LUNG INFECTION; MOUSE; NEWBORN; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; RESPIRATORY EPITHELIUM; TISSUE DISTRIBUTION;

AEROSOLS; ANIMALS; ANIMALS, NEWBORN; BACTERIAL ADHESION; DEXTRANS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; INTERLEUKIN-8; LUNG; MICE; MICE, INBRED BALB C; PNEUMONIA, BACTERIAL; POLYSACCHARIDES; PSEUDOMONAS INFECTIONS; RESPIRATORY THERAPY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033022734     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314755     Document Type: Article

References (23)

1. 1. Zopf DA, Roth S. Oligosaccharide anti-infective agents. Lancet 1996;347: 1017-21.
2. 2. Simon PM, Goode PL, Mobasseri A, Zopf D. Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid containing oligosaccharides. Infect Immun 1997;65:750-7.
3. 3. Krivan HC, Roberts DD, Ginsburg V. Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence (Ga1NAc1-4Ga1) found in some glycolipids. Proc Natl Acad Sci USA 1988;85:6157-61.
4. 4. Noah TL, Black HR, Cheng PW, Wood RE, Leigh MW. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. J Infect Dis 1997;175:638-47.
5. 5. Smith JJ, Travis SM, Greenberg EP, Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996; 85:229-36.
6. 6. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human β defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997;88:553-60.
7. 7. Tang H, Kays M, Prince A. Role of Pseudomonas aeruginosa pili in acute pulmonary infection. Infect Immun 1995;63:1278-85.
8. 8. Feldman M, Bryan R, Rajan S, et al. The role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection. Infect Immun 1998;66: 43-51.
9. 9. Saiman L, Prince A. Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells. J Clin Invest 1993;92:1875-80.
10. 10. DiMango E, Ratner AJ, Bryan R, Tabibi S, Prince A. Activation of NFκβ by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells. J Clin Invest 1998;101:2598-605.
11. 11. De Bentzmann S, Roger P, Dupuit F, et al. AsialoGM1 is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelial cells. Infect Immun 1996;64:1582-8.
12. 12. Dubick MA, Wade CE. A review of the efficacy and safety of 7.5% NaCl/6% dextran 70 in experimental animals and in humans. J Trauma 1994;36: 323-30.
13. 13. Barghouthi S, Guerdod L, Speert DP. Inhibition by dextran of Pseudomonas aeruginosa adherence to epithelial cells. Am J Respir Crit Care Med 1996;154:1788-93.
14. 14. Feng W, Garrett H, Speert DP, King M. Improved clearability of cystic fibrosis sputum with dextran treatment in vitro. Am J Respir Crit Care Med 1998;157:710-4.
15. 15. Cormack BP, Valdivia RH, Falkow S. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 1996;173:33-8.
16. 16. DiMango E, Zar HJ, Bryan R, Prince A. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 1995;96:2204-10.
17. 17. Gruenert DC, Basbaum CB, Welsh MJ, Finkbeiner WE, Nadel JA. Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci USA 1988;85:5951-5.
18. 18. DeBelder AN, Granath K. Preparation and properties of fluorescein-labeled dextrans. Carbohydr Res 1973;30:375-8.
19. 19. Fukuta S, Magnani JL, Twiddy EM, Holmes RK, Ginsburg VS. Comparison of the carbohydrate-binding specificities of cholera toxin and the E. coli heat labile enterotoxins Lth-I, LT-IIa, and LT-IIb. Infect Immun 1988; 56:1748-53.
20. 20. Quic PG, White JG, Holmes B, Good RA. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest 1967;46:668-79.
21. 21. Simpson DA, Ramphal R, Lory S. Genetic analysis of P. aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins. Infect Immun 1992;60:3771-9.
22. 22. Arcasoy SM, Latoche JD, Gondor M, Pitt BR, Pilewski JM. Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro. Gene Ther 1997;4:32-8.
23. 23. Schwartz DA, Quinn TJ, Thorne PS, Sayeed S, Yi AK, Krieg AM. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract. J Clin Invest 1997;100:68-73.