Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers

Clinical and Experimental Allergy

Volumn 28, Issue 2, 1998, Pages 141-150

  Mansur, A H ^a   Bishop, D T ^a   Markham, A F ^a   Britton, J ^b   Morrison, J F J ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

5q; Bronchial hyperreactivity; IFR I; IgE; IL4; IL9; Microsatellites analysis

Indexed keywords

CELL MARKER; IMMUNOGLOBULIN E; INTERFERON; METHACHOLINE; MICROSATELLITE DNA;

ADULT; AGED; ARTICLE; ASTHMA; ATOPY; BRONCHUS HYPERREACTIVITY; CASE CONTROL STUDY; CHROMOSOME 5Q; DISEASE CONTROL; DNA POLYMORPHISM; FORCED EXPIRATORY VOLUME; GENE MAPPING; GENETIC LINKAGE; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ALLELES; ASTHMA; BRONCHIAL HYPERREACTIVITY; CHROMOSOMES, HUMAN, PAIR 5; DNA; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; MALE; MICROSATELLITE REPEATS; MIDDLE AGED;

EID: 0031907519     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1998.00229.x     Document Type: Article

References (27)

1. Johansson SGO, Bennich HH, Berg T. The clinical significance of IgE. Prog Clin Immunol 1972; 1:1-25.
2. Burrows B, Martinez FD, Holanen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989; 320:271-7.
3. Halonen M, Stern D, Taussig LM, Wright A, Ray CG, Martinez FD. The predictive relationship between serum IgE levels at birth and subsequent incidences of lower respiratory illness and eczema in infants. Am Rev Respir Dis 1992; 146: 666-70.
4. Hopp RJ, Townley RG, Biven RE, Bewtra AK, Nair NM. The presence of airway reactivity before the development of asthma. Am Rev Respir Dis 1990; 141:2-8.
5. Burrows B, Sears MR, Flannery EM, Herbison GP, Holdaway MD. Relationship of bronchial responsiveness assessed by methacholine to serum IgE, lung function, symptoms, and diagnoses in 11-year-old New Zealand children. J Allergy Clin Immunol 1992; 90:376-85.
6. Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991; 325:1067-71.
7. Punnonen J, Aversa G, Cocks BG, de Vries JE. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells. Allergy 1994; 49:576-86.
8. Rennick D, Hunte B, Dang W, Thompson-Snipes L, Hudak S. Interleukin-10 promotes the growth of megakaryocyte, mast cell, and multilineage colonies: analysis with committed progenitors and Thyllo Scal + stem cells. Exp Hematol 1994; 22: 136-41.
9. Adachi T, Motojima S, Hirata A, Fukuda T, Makino S. Eosinophil viability-enhancing activity in sputum from patients with bronchial asthma, Contributions of interleukin-5 and granulocyte/macrophage colony-stimulating factor. Am J Respir Crit Care Med 1995; 151:618-23.
10. Marsh DG, Neely JD, Breazeale DR et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264:1152-5.
11. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, Borish L. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995; 25: Suppl 2, 74-8, discussion 95-6.
12. Meyers DA, Postma DS, Panhuysen CIM et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994; 23:464-70.
13. Postma DS, Bleeker ER, Amelung PJ et al. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995; 333:894-900.
14. Doull IJM, Lawrence S, Watson M et al. Allelic association of gene markers on chromosome 5q and 11q with atopy and bronchial hyperresponsiveness. Am J Respir Crit Care Med 1996; 153:1280-4.
15. Daniels SE, Bhattacharrya S, James A et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996; 383:247-50.
16. Blumenthal MN, Wang Z, Weber JL. Rich SS. Absence of linkage between 5q markers and serum IgE levels in four large atopic families. Clin Exp Allergy 1996; 26:892-6.
17. Boyer S, Pereira E, Palmer L, Rye P, Goldblatt J, Sanderson C, Le Souef P. Confirmation of the presence of a polymorphism in the interleukin 4 promoter in an asthmatic cohort. Am J Respir Crit Care Med 1996; 151:A470.
18. Britton J, Pavord I, Richard K et al. Factors influencing the occurrence of airway hyperreactivity in the general population: the importance of atopy and airway calibre. Eur Respir J 1994; 7:881-7.
19. Yan K, Salome C, Woolcock AJ. Rapid method for measurement of bronchial responsiveness. Thorax 1983; 38:760-5.
20. Fleiss. Statistical methods for rates and proportions. 2nd Edn. Wiley, 1981: 38-45.
21. Shave PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 1995; 59:97-105.
22. Holroyd KJ, Levitt RC, Dragwa C, Amelung PJ, Panhuysen CIM, Meyers DA, Bleeker ER, Postma DS. Evidence for β2 adrenoceptor polymorphism at amino acid 16 as a risk factor for bronchial hyperresponsiveness. Am J Resp Crit Care Med 1995; 151:A673.
23. Hall IP, Wheatley A, Wilding P, Liggett SB. Association of Glu27 β2-adrenoceptor polymorphism with lower bronchial reactivity in asthmatic subjects. Lancet 1995; 345:1213-4.
24. Murray JC, Buetow KH, Webber JL et al. A comprehensive human linkage map with centimorgan density. Science 1994; 265:2049-54.
25. Gyapay G, Morissette J, Vignal A et al. The 1993-1994 Genothon human genetic linkage map. Nature Gen 1994; 7:246-339.
26. Dib C, Faure S, Fizames C et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 1996; 380:152-4.
27. Collins A, Frezal J, Teague J, Morton NE, A metric map for the humans, 23,500 loci in 850 Bands. Proc Natl Acad Sci USA 1996; 93:14771-5.