Apoptosis of T cells and macrophages in the central nervous system of intact and adrenalectomized Lewis rats during experimental allergic encephalomyelitis

Journal of Autoimmunity

Volumn 9, Issue 2, 1996, Pages 167-174

  Smith, Terence ^a   Schmied, Mascha ^a,b   Hewson, Adrian K ^a   Lassmann, Hans ^b   Cuzner, M Louise ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

Apoptosis; Corticosterone; Experimental allergic encephalomyelitis (EAE); Lewis rat; Macrophages; T cells

Indexed keywords

CORTICOSTERONE; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL TRANSFER; CONTROLLED STUDY; FEMALE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD LESION; SPLEEN CELL; T LYMPHOCYTE;

EID: 0029906438     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0020     Document Type: Article

References (40)

1. Richert J.R., Driscol B.F., Kies M.W., Alvord E.C. 1981. Experimental allergic encephalomyelitis: Activation of myelin basic protein-sensitized spleen cells by specific antigen in culture. Cell. Immunol. 59: 42-53
2. MacPhee I.A.M., Antoni F.A., Mason D.W. 1989. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J. Exp. Med. 169: 431-445
3. Sternberg E.M., Glowa J.R., Smith M.A., Calogero A.E., Listwak S.J., Aksentijevich S., Chrousos G.P., Wilder R.L., Gold P.W. 1992. Corticotropin releasing hormone related behavioural and neuroendocrine responses to stress in Lewis and Fischer rats. Brain Res. 570: 54-60
4. 2 and cAMP production and adrenocortical activation following intra-peritoneal endotoxin injection: in vivo microdialysis studies in Lewis and Fischer rats. Neuroendocrinology 59: 396-405
5. Mason D., MacPhee I., Antoni F. 1990. The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat. Immunology 70: 1-5
6. Leonard J.P., MacKenzie F.J., Patel H.A., Cuzner M.L. 1991. Hypothalamic noradrenergic pathways exert an influence on neuroendocrine and clinical status in experimental autoimmune encephalomyelitis. Brain Behav. Immun. 5: 328-338
7. Gillis S., Crabtree G.R., Smith K.A. 1979. Gulcocorticoid-induced inhibition of T cell growth factor production. J. Immunol. 123: 1632-1638
8. Snyder D.S., Ueanue E.R. 1982. Corticosteroids inhibit immune macrophage la expression and interleukin 1 production. J. Immunol. 129: 1803-1805
9. Beutler B., Krochin N., Milsark I.W., Leudke C., Cerami A. 1986. Control of cachectin (tumour necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232: 977-980
10. Tanabe O., Akira S., Kamiya T., Wong G.G., Hirano T., Kishimoto T. 1988. Genomic structure of the murine IL-6 gene. High degree of conservation of potential regulatory sequences between mouse and human. J. Immunol. 141: 3875-3881
11. Paul C., Bolton C. 1994. Restoration of blood brain barrier integrity by dexamethasone and cyclosporin A combined dose therapy during experimental allergic encephalomyelitis. J. Neuroimmunol. 58: 188
12. Cronstein B., Kimmel S., Levin R., Martiniuk F., Weissman G. 1992. A mechanism for the anti-inflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion. Proc. Natl. Acad. Sci. USA 89: 9991-9995
13. Mukaida N., Zacariae C.C.O., Gusella G.L., Matsushima K. 1991. Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1 or TNF. J. Immunol. 146: 1212-1215.
14. Wyllie A.H. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556
15. Migliorati G., Nicoletti I., D'Adamio F., Spreca A., Pagliacci C., Riccardi C. 1994. Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes. Immunology 81: 21-26
16. Schmied M., Breitschopf H., Gold R., Zischler H., Rothe G., Wekerle H., Lassmann H. 1993. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 143: 446-452
17. Cox J., Ford W. 1982. The migration of lymphocyte across specialised vascular endothelium. Cell. Immunol. 66: 407-413
18. Matsumoto Y., Fujiwara M. 1987. The immunopathology of adoptively transferred experimental allergic encephalomyelitis (EAE) in Lewis rats. J. Neurol Sci. 77: 35-47
19. Panitch H.S., McFarlin D.E. 1979. Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A. J. Immunol. 119: 1134-1137
20. Huitinga I., Van Roojien N., de Groot C.J.A., Uitdehaag B.M.J., Dijkstra C.D. 1990. Suppression of experimental allergic encepahlomyelitis in Lewis rats after elimination of macrophages. J. Exp. Med. 172: 1025-1033
21. Merrill J.E., Kono D.H., Clayton J., Ando D.G., Hinton D.R., Hofman F.M. 1992. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc. Natl. Acad. Sci. USA 89: 574-578
22. + population during recovery. J. Neuroimmunol. 48: 105-117
23. Varriale S., Beraud E., Barbaria J., Galibert R., Bernard D. 1994. Regulation of experimental allergic encephalomyelitis: inhibition of adoptive experimental autoimmune encephalomyelitis by recovery-associated suppressor cells. J. Neuroimmunol. 53: 123-131
24. Pender M.P., Nguyen K.B., McCombe P.A., Kerr J.F.R. 1991. Apoptosis in the nervous system in experimental allergic encephalomyelitis. J. Neurol. Sci. 104: 81-87
25. Pender M.P., McCombe A., Yoong G., Nguyen K.B. 1992. Apoptosis of αβ lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: its possible implications for recovery and acquired tolerance. J. Autoimmun. 5: 401-410
26. + encephalitogenic T cells. Eur. J. Immunol. 24: 2609-2617
27. Nieto M.A., Gonzales A., Gambon F., Diaz-Espada F., Lopez-Rivas C. 1992. Apoptosis in human thymoctyes after treatment with glucocorticoids. Clin. Exp. Immunol. 88: 341-344
28. Tuosto L., Cundari E., Montani M.S.G., Piccolella E. 1994. Analysis of susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis. Eur. J. Immunol. 24: 1061-1065
29. Salmon M., Pilling D., Borthwick N.J., Viner N., Janossy G., Bacon P.A., Akbar A.N. 1994. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur. J. Immunol. 24: 892-899
30. Cross A.H., Cannella B., Brosnan C.F., Raine C.S. 1991. Hypothesis: Antigen-specific T cells prime central nervous system endothelium for recruitment of nonspecific inflammatory cells to effect autoimmune demyelination. J. Neuroimmunol. 33: 237-244
31. McConkey D., Hartzell J.P., Chow S.C., Orrenius S., Jondal M. 1990. Interleukin-1 inhibits T-cell receptor mediated apoptosis in immature thymocytes. J. Biol. Chem. 265: 3009-3011
32. Duke R.C., Cohen J.J. 1986. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res. 5: 289-299
33. Zacharchuk C.M., Mercep M., Chakraborti P.K., Simons S.S., Ashwell J.D. 1990. Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 145: 4037-4045
34. Laster S.M., Wood J.G., Gooding L.R. 1988. Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis. J. Immunol. 141: 2629-2634
35. Critfield J.M., Racke M.K., Zuniga-Pflucker J.C., Cannella B., Raine C.S., Goverman J., Lenardo M.J. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263: 1139-1143
36. Nguyen K.B., McCombe P.A., Pender M.P. 1994. Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. J. Autoimmun. 7: 145-152
37. Zeine R., Owens T. 1993. Loss rather than downregulation of CD4+ T cells as a mechanism for remission from experimental allergic encephalomyelitis. J. Neuroimmunol. 44: 193-198.
38. Compton M.M., Cidlowski J.A. 1992. Thymocyte apoptosis: a model of programmed cell death. Trends Endocrinol Metab. 3: 17-23
39. Wyllie A.H., Kerr J.F.R., Currie A.R. 1980. Cell death: the significance of apoptosis. Int. Rev. of Cytology 68: 251-306
40. Fadok V.A., Voelker D.R., Campbell P.A., Cohen J.J., Bratton D.L., Henson P.M. 1992. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148: 2207-2216