Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes

Neurochemical Research

Volumn 21, Issue 9, 1996, Pages 1141-1148

  Wilkie, G I ^a   Hutson, P ^b   Sullivan, J P ^c   Wonnacott, S ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c ABBOTT LABORATORIES   (United States)

Author keywords

(+) anatoxin a; ( ) cytisine; ( ) nicotine; ABT 418; acetylcholine release; epibatidine; nicotinic autoreceptor; nicotinic receptor subtypes; Rat hippocampus

Indexed keywords

3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; ANATOXIN A; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; DOSE RESPONSE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

ACETYLCHOLINE; ACONITINE; ANIMALS; CALCIUM; CHOLINE; DIHYDRO-BETA-ERYTHROIDINE; HIPPOCAMPUS; MECAMYLAMINE; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PEMPIDINE; POTASSIUM CHLORIDE; RATS; RECEPTORS, NICOTINIC; SYNAPTOSOMES;

ANIMALIA;

EID: 0029800519     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02532425     Document Type: Article

References (48)

1. Wonnacott, S., Drasdo, A., Sanderson, E., and Rowell, P. 1990. Presynaptic nicotinic receptors and the modulation of transmitter release. Pages 87-101, in Marsh, J. (ed.), Ciba Foundation Symposium 152: The Biology of Nicotine Dependence, John Wiley and Sons, Chichester.
2. McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., and Role, L. W. 1995. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269:1692-1696.
3. Rapier, C., Lunt, G. G., and Wonnacott, S. 1988. Stereoselective nicotine-induced release of dopamine from striatal synaptosomes: concentration dependence and repetitive stimulation. J. Neurochem. 50:1123-1130.
4. 3H]dopamine release from striatal synaptosomes: pharmacological characterisation. J. Neurochem. 54:937-945.
5. 3H]dopamine release from synaptosomes prepared from mouse striatum. J. Neurochem. 59:848-856.
6. El-Bizri, H. and Clarke, P. B. S. 1994. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Brit. J. Pharmacol. 111:406-413.
7. 3H]dopamine release from rat striatal synaptosomes. Neuropharmacol. 34:1535-1541.
8. 3H]dopamine release from rat striatal synaptosomes. J. Neurochem. 67:163-170.
9. Rapier, C., Wonnacott, S., Lunt, G. G., and Albuquerque, E. X. 1987. The neurotoxin histrionicotoxin interacts with the putative ion channel of the nicotinic acetylcholine receptors in the central nervous system. Febs Lett. 212:292-296.
10. Drasdo, A., Caulfield, M. P., Bertrand, D., Bertrand, S., and Wonnacott, S. 1992. Methyllycaconitine: a novel nicotinic antagonist. Mol. Cell. Neurosci. 3:237-243.
11. Sacaan, A. I., Dunlop, J. L., and Lloyd, G. K. 1995. Pharmacological characterisation of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal dopamine release from rat brain slices. J. Pharmacol. Exp. Ther. 274:224-230.
12. 3H]dopamine release. Brit. J. Pharmacol. 117:595-606.
13. Sargent, P. B. 1993. The diversity of neuronal nicotinic acetylcholine receptors. Ann. Rev. Neurosci. 16:403-443.
14. Wada, E., Wada, K., Boulter, J., Deneris, E., Heinemann, S., Patrick, J., and Swanson, L. W. 1989. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridisation histochemical study in the rat. J. Comp. Neurol. 284:314-335.
15. Dineley-Miller, K., and Patrick, J. 1992. Gene transcripts for the nicotinic acetylcholine receptor subunit, beta4, are distributed in multiple areas of the rat central nervous system. Mol. Brain Res. 16:339-344.
16. Wada, E., McKinnon, D., Heinemann, S., Patrick, J., and Swanson, L. 1990. The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system. Brain Res. 526:45-53.
17. Bowman, W. C., Marshall, I. G., Gibb, A. J., and Harborne, A. J. 1988. Feedback control of transmitter release at the neuromuscular junction Trends Pharmacol. Sci. 9:16-20.
18. 3H]acetylcholine release from mouse cerebral cortical synaptosomes. J. Neurochem. 43:1593-1598.
19. 3H]methylcarbamylcholine binding sites and effect of N-methylcarbamylcholine on acetylcholine release in rat brain. J. Neurochem. 51:292-299.
20. Whiting, P., Esch, F., Shimasaki, S., and Lindstrom, J. 1987. Neuronal nicotinic acetylcholine receptor β-subunit is coded for by the cDNA clone α4. FEBS Lett. 219:459-463.
21. Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., and Kellar, K. J. 1992. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment Mol. Pharmacol. 41:31-37.
22. Araujo, D. M., Lapchak, P. A., Robitaille, Y., Gauthier, S., and Quirion, R. 1988. Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J. Neurochem. 50:1914-1923.
23. Williams, M., Sullivan, J. P., and Arneric, S. P. 1994. Neuronal nicotinic acetylcholine receptors. Drug News And Perspectives 7: 205-223.
24. Holladay, M. W., Lebold, S. A., and Nan-Horng, L. 1995. Structure-activity relationships of nicotinic acetylcholine receptor agonists as potential treatments for dementia. Drug Dev. Res. 353:191-213.
25. Clarke; P. B. S. and Pert, A. 1985. Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons. Brain Res. 348:355-358.
26. Wilkie, G. I., Stephens, M. W., Hutson, P. J., Whiting, P., and Wonnacott, S. 1993. Hippocampal nicotinic autoreceptors modulate acetylcholine release. Biochem. Soc. Trans. 21:429-431.
27. Thorne, B., Wonnacott, S., and Dunkley, P. R. 1991. Isolation of hippocampal synaptosomes on Percoll gradients: cholinergic markers and ligand binding sites. J. Neurochem. 56:479-484.
28. Thorne, B. 1990. Nicotinic regulation of acetylcholine release from rat brain hippocampus. PhD Thesis, University of Bath.
29. Thorne, B., Irons, J., Lunt, G. G., Wonnacott, S., and Dunkley, P. R. 1988. Comparison of methods for rapid isolation of synaptosomes from brain regions, for uptake and release studies. Biochem. Soc. Trans. 16:309-310.
30. Garvey, D. S., Wasicak, J., Decker, M. W., Brioni, J. D., Buckley, M. J., Sullivan, J. P., Carrera, G. M., Holladay, M. H., Arneric, S. P., and Williams, M. 1994. Novel isoxazoles which interact with brain cholinergic channel receptors that have intrinsic cognitive enhancing and anxiolytic properties. J. Med. Chem. 37:1055-1059.
31. Rowell, P. R., & Hillebrand, J. A. 1994. Characterisation of nicotine-induced desensitisation of evoked dopamine release from rat striatal synaptosomes. J. Neurochem. 63:561-569.
32. Badio, B., and Daly, J. W. 1994. Epibatidine, a potent analgetic and nicotinic agonist. Mol. Pharmacol. 45:563-569.
33. Sullivan, J. P., Decker, M. W., Brioni, J. D., Donnelly-Robert, D., Anderson, D. J., Bannon, A. W., Kang, C.-H., Adams, P., Piattoni-Kaplan, M., Buckley, M. J., Gopalakrishnan, Williams, M., and Arneric, S. 1994. (±)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 271:624-631.
34. Arneric, S. P., Sullivan, J. P., Briggs, C. A., Donnelly-Roberts, D., Anderson, D. J., Raszkiewicz, J. L., Hughes, M. L., Cadman, E. D., Adams, P., Garvey, D. S., Wasicak, J. T., and Williams, M. 1994. (S)-3-Methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT-418): A novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterisation. J. Pharmacol. Exp. Ther. 270: 310-318.
35. Arneric, S. P., Anderson, D. A., Bannon, A. D., Brioni, J. D., Briggs, C. A., Buccafusco, J., Decker, M. W., Donnelly-Roberts, D., Godalakrishnan, M., Holladay, M. W., and Sullivan, J. P. 1995. Preclinical pharmacology of ABT-418: a prototypical cholinergic channel activator for the treatment of Alzheimer's disease. CNS Drug Rev. 1:1-26.
36. Whiteaker, P., Garcha, H. S., Wonnacott, S., and Stolerman, I. P. 1995. Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats. Brit. J. Pharmacol. 116:2097-2105.
37. Wong, E. T., Holstad, S. G., Mennerick, S. J., Hong, S. E., Zorumski, C. F., and Isenberg, K. E. 1995. Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, alpha3beta4, expressed in transfected eukaryotic cells. Mol. Brain Res. 28:101-109.
38. Thomas, P., Stephens, M., Wilkie, G., Amar, M., Lunt, G. G., Whiting, P., Gallagher, T., Pereira, E., Alkondon, M., Albuquerque, E. X., and Wonnacott, S. 1993. (+)-anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J. Neurochem. 60:2308-2311.
39. Vibat, C. R. T., Lasalde, J. A., McNamee, M. G., and Ochoa, E. L. M. 1995. Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus oocytes. Cell. Mol. Neurobiol. 15:411-425.
40. Luetje, C. W., and Patrick, J. 1991. Both α- and β-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J. Neurosci. 11:837-845.
41. Papke, R. and Heinemann, S. 1991. The role of the β4 subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine α3 receptors. J. Physiol. (London) 440:95-112.
42. Marks, M. J., Farnham, D. A., Grady, S. R., and Collins, A. C. 1993. Nicotinic receptor function determined by stimulation of rubidium efflux from mouse brain synaptosomes. J. Pharmacol. Exp. Ther. 264:542-552.
43. Peng, X., Gerzanich, V., Anand, R., Whiting, P. J., and Lindstrom, J. 1994. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46:523-530.
44. Court, J. A., Perry, E. K., Spurden, D., Lloyd, S., Gillespie, J. I., Whiting, P., and Barlow, R. 1994. Comparison of the binding of nicotinic agonists to receptors from human and rat cerebral cortex and from chick brain (α4β2) transfected into mouse fibroblasts with ion channel activity. Brain Res. 667:118-122.
45. Conroy, W. G., Vernallis, A. B., and Berg, D. K. 1992. The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain. Neuron 9:679-691.
46. Wonnacott, S., Wilkie, G., Soliakov, L., and Whiteaker, P. 1995. Presynaptic nicotinic autoreceptors and heteroreceptors in the CNS, in Effects Of Nicotine On Biological Systems II Ed. P. B. S. Clarke, M. Quik, F. Adlkofer & K. Thurau, Birkhauser Verlag, pp 87-94.
47. Marley, P. D. 1988. Desensitisation of the nicotinic secretory response of adrenal chromaffin cells. Trends in Pharmacol. Sci. 9: 102-107.
48. 3H]dopamine release from mouse striatal synaptosomes. J. Neurochem. 62:1390-1398.