Effects of peptide structure on transport properties of seven thyrotropin releasing hormone (TRH) analogues in a human intestinal cell line (Caco-2)

Pharmaceutical Research

Volumn 14, Issue 2, 1997, Pages 246-250

  Werner, Ute ^a   Kissel, Thomas ^a   Stüber, Werner ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Behringwerke AG   (Germany)

Author keywords

Caco 2 cells; Hydrogen bonding; Lipophilicity; Peptide transport; Structure permeation relationship

Indexed keywords

PROTIRELIN DERIVATIVE;

ACTIVE TRANSPORT; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INTESTINE ABSORPTION; LIPOPHILICITY; MOLECULAR WEIGHT; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; DRUG STABILITY; HUMANS; MOLECULAR WEIGHT; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; THYROTROPIN-RELEASING HORMONE;

EID: 0030938091     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012021315576     Document Type: Article

References (15)

1. P. L. Smith, D. A. Wall, C. H. Gochoco, and G. Wilson. Adv. Drug Deliv. Rev. 8:253-290 (1992).
2. V. H. L. Lee and A. Yamamoto. Adv. Drug Deliv. Rev. 4:171-207 (1990).
3. M. D. Donovan, G. L. Flynn and G. L. Amidon. Pharm. Res. 8:863-868 (1990).
4. P. Artursson. J. Pharm. Sci. 79:476-482 (1990).
5. K. Palm, K. Luthman, A.-L. Ungell, G. Strandlund, and P. Artursson. J. Pharm. Sci. 85:32-39 (1996).
6. R. A. Conradi, A. R. Hilgers, N. F. H. Ho, and P. S. Burton. Pharm. Res. 9:435-439 (1992).
7. G. T. Knipp, D. van der Velde, T. J. Siahaan, and R. T. Borchardt. Pharm. Res. 12:PDD 7441, S-303 (1995).
8. S. Lundin, J. Møss, H. Bundgaard, and P. Artursson. Int. J. Pharm. 86:R1-R4 (1991).
9. E. Walter and T. Kissel. Pharm. Res. 11:1575-1580 (1994).
10. J. C. Caron and B. Shroot. J. Pharm. Sci. 73:1703-1706 (1984).
11. W. D. Stein. In: The Movement of Molecules across Cell Membranes. Academic Press, NY, pp. 65-125 (1967).
12. K. Yamada, M. Murakami, A. Yamamoto, K. Takada, and S. Muranishi. J. Pharm. Pharmacol. 44:717-721 (1991).
13. S. Yokohama, T. Yoshioka, K. Yamashita, and N. Kitamori. J. Pharm. Dvn. 7:445-451 (1984).
14. P. L. Nicklin and W. J. Irwin. J. Pharm. Pharmacol. 43:103 P (1991).
15. P. S. Burton, R. A. Conradi, A. R. Hilgers, N. F. H. Ho, and L. L. Maggiora. J. Contr. Rel. 19:87-98 (1992).