Studies on the effect of the combined expression of anti-tat and anti-rev genes on HIV-1 replication

Gene Therapy

Volumn 4, Issue 4, 1997, Pages 288-295

  Caputo, A ^a   Rossi, C ^a   Bozzini, R ^a   Betti, M ^a   Grossi, M P ^a   Barbanti Brodano, G ^a   Balboni, P G ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Gene therapy; HIV 1; RRE decoy; tat and rev mutants

Indexed keywords

REV PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL CLONE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA CELL LINE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS GENE; VIRUS RECOMBINANT; VIRUS REPLICATION;

EID: 0030967207     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300393     Document Type: Article

References (32)

1. Cullen BR. Regulation of HIV gene expression AIDS 1995; 9 (Suppl. A): S19-S32
2. Nabel GJ. Gene therapy approaches to AIDS. AIDS 1994; 8 (Suppl. 1): S61-S69.
3. Yu M, Pocschla E, Wong-Staal F. Progress towards gene therapy for HIV infection. Gene Therapy 1994; 1: 13-26.
4. Malim MH, Böhnlein S, Hauber J, Cullen BR. Functional dissection of the HIV-1 Rev trans-activator. Derivation of a transdominant repressor of Rev function. Cell 1989; 58: 205-214.
5. Venkatesh LK, Chinnadurai G. Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype. Virology 1990; 178: 327-330.
6. Malim MH et al. Stable expression of trartsdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J Exp Med 1992, 176: 1197-1201.
7. Bevec D, Dobrovnik M, Hauber J, Böhnlein E. Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator. Proc Natl Acad Sci USA 1992; 89: 9870-9874.
8. Bahner I et al Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes. J Virol 1993; 67: 3199-3207.
9. Liu J, Woffendin C, Yang Z-Y, Nabel GJ. Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells. Gene Therapy 1994; 1: 32-37.
10. - T lymphocytes by retroviral vectors expressing anti-HIV genes. J Virol 1995; 69: 4045-4052.
11. Lee TC et al. Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells. New Biol 1992; 4: 66-74.
12. Zimmermann K et al. Expression of chimeric Neo-Rev response element sequences interferes with Rev-dependent HIV-1 Gag expression. Hum Gene Ther 1992; 3: 155-161.
13. - T lymphocytes. Hum Gene Ther 1994; 5: 193-201.
14. Lee SW, Gallardo HF, Gilboa E, Smith C. Inhibition of human immunodeficiency virus type 1 in human T cells by a potent Rev response element decoy consisting of 13-nucleotide minimal Rev-binding domain. J Virol 1994; 68: 8254-8264.
15. Balboni PG et al. Inhibition of human immunodeficiency virus reactivation from latency by a Tat transdominant negative mutant. J Med Virol 1993; 41: 289-295.
16. Pengue G et al. Transcriptional silencing of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by the Krüppel-associated box repressor domain targeted to the transactivating response element. J Virol 1995; 69: 6577-6580.
17. Caputo A et al. Inhibition of HIV-1 replication and reactivation from latency by Tat transdominant negative mutants in the cysteine rich region. Gene Therapy 1996; 3: 235-245.
18. Liem SE, Ramezani A, Li X, Joshi S. The development and testing of retroviral vectors expressing trans-dommant mutants of HIV-1 proteins to confer anti-HIV-1 resistance. Hum Gene Ther 1993; 4: 625-634.
19. Lori F et al. Rapid protection against human immunodeficiency virus type 1 (HIV-1) replication mediated by high efficiency non-retroviral delivery of genes interfering with HIV-1 Tat and Gag. Gene Therapy 1994; 1: 27-31.
20. Aguilar-Cordova E et al. Inhibition of HTV-1 by a double transdominant fusion gene. Gene Therapy 1995; 2: 181-186.
21. Ulich C, Harrich D, Estes P, Gaynor RB. Inhibition of human immunodeficiency virus type 1 replication is enhanced by a combination of transdominant Tat and Rev proteins. J Virol 1996; 70: 4871-4876.
22. Peng H, Callison D, Li P, Burrel C. Long-term protection against HIV-1 infection conferred by tat or rev antisense RNA was affected by the design of the retroviral vector. Virology 1996; 220: 377-379.
23. Lisziewicz J et al. Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy m AIDS. Proc Natl Acad Sci USA 1993; 90: 8000-8004.
24. Chen S-Y, Bagley J, Marasco WA. Intracellular antibodies as a new class of therapeutic molecules for gene therapy. Hum Gene Ther 1994; 5: 595-601.
25. Junker U, Bohnlein E, Veres G. Genetic instability of a MoMLV-base antisense double-copy retroviral vector designed for HIV-1 gene therapy. Gene Therapy 1995; 2: 639-646.
26. Chuah MKL et al. Inhibition of human immunodeficiency virus type-1 by retroviral vectors expressing antisense-TAR. Hum Gene Ther 1994; 5: 1467-1475.
27. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989; 7: 980-990.
28. Wu X, Holschen j, Kennedy SC, Ponder KP. Retroviral vector sequences may interact with some internal promoters and influence expression Hum Gene Ther 1996; 7: 159-171.
29. Kunkel TA, Roberts JD, Zakour RA. Rapid and efficient site-specific mutagenesis without selection. Meth Enzymol 1987; 154: 367-382.
30. Lenz J, Haseltine WA. Localization of the leukemogenic determinants of SL3-3, an ecotropic, XC-positive murine leukemia virus of AKJR mouse origin. J Virol 1983; 47: 317-328.
31. Davis LG, Dibner MD, Battey JF. Basic Methods in Molecular Biology. Elsevier Science Publishing: New York, 1986.
32. Ou C-Y et al. DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science 1988; 239: 295-297.