Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand

Clinical and Experimental Immunology

Volumn 116, Issue 3, 1999, Pages 441-448

  Huang, S C ^a,d   Glas, A M ^a,b   Pinchuk, G V ^a,c,f   Van Montfort, E H N ^a,b   Rao, S P ^a,e   Jiang, R ^a   Milner, Eric C B ^a,g  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c BOGOMOLETZ INSTITUTE OF PHYSIOLOGY   (Ukraine)

^d PROMEGA CORPORATION   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f MISSISSIPPI STATE UNIVERSITY   (United States)

^g BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

Antibodies; B lymphocytes; Generation of diversity; T cell B cell collaboration

Indexed keywords

GLYCOPROTEIN GP 39;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL CONTACT; CELL PROLIFERATION; DNA SEQUENCE; GERMINAL CENTER; HELPER CELL; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; LYMPHOCYTE CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; T LYMPHOCYTE;

EID: 0032994506     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00919.x     Document Type: Article

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