Structure-based design of nonnatural ligands for the HLA-B27 protein

Journal of Receptor and Signal Transduction Research

Volumn 19, Issue 1-4, 1999, Pages 645-657

  Dédier, Séverine ^a   Krebs, Stefan ^a   Lamas, José R ^b   Poenaru, Sorana ^a   Folkers, Gerd ^a   López De Castro, José A ^b   Seebach, Dieter ^a   Rognan, Didier ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; EPITOPE; HLA B27 ANTIGEN; IMMUNOMODULATING AGENT; UNDECANOIC ACID;

ANTIGEN BINDING; BINDING AFFINITY; BINDING SITE; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG SYNTHESIS; IMMUNOMODULATION; PROTEIN MODIFICATION; PROTEIN STABILITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

EID: 0032993305     PISSN: 10799893     EISSN: None     Source Type: Journal    
DOI: 10.3109/10799899909036677     Document Type: Conference Paper

References (17)

1. Heemels, M. T.; and Ploegh, H.L. Generation, translocation and presentation of MHC class I-restricted peptides. Annu. Rev. Biochem. 64, 643-691, 1995.
2. López de Castro, J.A. The pathogenetic role of HLA-B27 in chronic arthritis. Curr. Opin. Immunol. 10, 59-66, 1998.
3. Rognan, D.; Scapozza, L.; Folkers, G.; and Daser, A. Rational design of nonnatural peptides as high affinity ligands for the HLA-B*2705 human leucocyte antigen. Proc. Natl. Acad. Sci. USA 92, 753-757, 1995.
4. Krebs, S.; Lamas, J.R.; Poenaru, S.; Folkers, G.; López de Castro, J.A.; Seebach, D.; and Rognan, D. Substituting nonpeptidic spacers for the T-cell receptor binding part of class I MHC-binding peptides. J. Biol. Chem. in press, 1998.
5. Seebach, D.; Poenaru, S.; Folkers, G.; and Rognan, D. Synthesis of oligo (3-hydroxybutanoate) (OHB)-containing peptides with high binding affinity to a class I-MHC protein. submitted to Helv. Chim. Acta, 1998.
6. Poenaru, S.; Lamas, J.R.; Folkers, G.; López de Castro, J.A.; Seebach, D.; and Rognan, D. Nonapeptide analogues containing (R-3-hydroxybutanoate and β-homoalanine oligomers : synthesis and binding affinity to a class I-MHC protein, in preparation
7. Galocha, B.; Lamas, J.R.; Villadangos, J.A.; Albar, J.P.; and López de Castro, J.A. Binding of peptides naturally presented to HLA-B27 to the differentially desease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism. Tissue Antigens 48, 509-518, 1996.
8. Bouvier, M.; and Wiley, DC. Importance of peptide amino and carboxyl termini to the stability of the MHC class I molecules. Science 265, 398-402, 1994.
9. Weiss, G.A.; Collins, E.J.; Garboczi, D.M.; Wiley, D.C.; and Schreiber, S.L. A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules. Chemistry & Biology 2, 401-407, 1995.
10. Weiss, G.A.; Valentekovich, R.J.; Collins, E.J.; Garboczi, D.N.; Lane, W.S.; Schreiber, S.L.; and Wiley, D.C. Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine. Proc. Natl. Acad. Sci. USA. 93, 10945-10948, 1996.
11. Reich, Z.; Altman, J.D.; Boniface, J.J.; Lyons, D.S.; Kozono, H.; Ogg, G.; Morgan, C.; and Davis, M.M. Stability of empty and peptide-loaded class II major hiytocompatibiliy complex molecules at neutral and endosomal pH : comparison to class I proteins. Proc. Natl. Acd. Sci. USA. 94, 2495-2500, 1997.
12. Garcia, F.; Marina, A.; and López de Castro, J.A. HLA-B27 presents a peptide from a polymorphic region of its own molecule with homology to proteins from arthritogenic bacteria. Tissue Antigens 49, 215-221, 1996.
13. Plattner, D.A.; Brunner, A.; Dobler, M.; Müller, H.-M.; Petter, W.; Zbinden, P.; and Seebach, D. Cyclische oligomere von (R)-3-hydroxybuttersäure : Herstellung und strukturelle Aspekte. Helv. Chim. Acta 76, 2004-2033, 1993.
14. Rognan, D.; Krebs, S.; Kuonen, O.; Lamas, J.R.; López de Castro, J.A.; and Folkers, G. Fine specificity of antigen binding to two class I major histocompatibility proteins (B*2705 and B*2703) differing in a single amino acid residue. J. Comp.-Aided Mol. Des. 11, 463-478, 1997.
15. Rognan, D.; Scapozza, L.; Folkers, G.; and Daser, A. Molecular dynamics simulation of MHC-peptide complexes as a tool for predicting potential T cell epitopes. Biochem. 33, 11476-11485, 1994.
16. Morgan, C.S.; Holton, J.M.; Olafson, B.D.; Bjorkman, P.J.; and Mayo, S. L. Circular dichroism determination of class I MHC peptide equilibrium dissociation constants. Prot. Sci. 6, 1771-1773, 1997.
17. Rammensee, H.-G.; Friede, T.; and Stevanovic, S. MHC ligands and peptide motifs : first listing (review). Immunogenetics 41, 178-228, 1995.