Immunostimulatory properties of genomic DNA from different bacterial species

Immunobiology

Volumn 200, Issue 1, 1999, Pages 106-119

  Neujahr, David C ^a   Reich, Charles F ^a   Pisetsky, David S ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; LIPOFECTIN;

ARTICLE; B LYMPHOCYTE; CELL CULTURE; CLOSTRIDIUM PERFRINGENS; DNA BASE COMPOSITION; ESCHERICHIA COLI; IMMUNOSTIMULATION; MICROCOCCUS LUTEUS; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STAPHYLOCOCCUS AUREUS; THYMUS;

EID: 0032992448     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(99)80036-9     Document Type: Article

References (32)

1. TOKUNAGA, T., H. YAMAMOTO, S. SHIMADA, H. ABE, T. FUKADA, Y. FJISAWA, Y. FURUTANI, O. YANO, T. KATAOKA, T. SUDO, N. MAKIGUCHI, and T. SUGANUMA. 1984. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72: 955.
2. TOKUNAGA, T., O. YANO, E. KURAMOTO, Y. KIMURA, T. YAMAMOTO, T. KATAOKA, and S. YAMAMOTO. 1992. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 36: 55.
3. MESSINA, J. P., G. S. GILKESON, and D. S. PISETSKY. 1991. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 132: 872.
4. KRIEG, A. M., A. K. YI, S. MATSON, T. J. WALDSCHMIDT, G. A. BISHOP, R. TEASDALE, G. A. KORETZKY, and D. M. KLINMAN. 1995. CpG motifs in bacterial DNA trigger direct B cell activation. Nature 156: 546.
5. COWDERY, J. S., J. H. CHACE, A.-K. YI, and A. M. KRIEG. 1996. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156: 4570.
6. SPARWASSER, T., T. MIETHKE, G. LIPFORD, A. ERDMAN, H. HACKER, K. HEEG, and H. WAGNER. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27: 1671.
7. SPARWASSER, T., T. MIETHKE, G. LOPFORD, K. BORSCHERT, H. HACKER, K. HEEG, H. WAGNER. 1997. Bacterial DNA causes septic shock. Nature 386: 336.
8. ROMAN, M., E. MARTIN-OROZCO, J. GOODMAN, M. NGUYEN, Y. SATO, A. RONAGHY, R. KORNBLUTH, D. RICHMAN, D. CARSON, and E. RAZ. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nature Med: 3: 849.
9. PISETSKY, D. S. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5: 303.
10. SUN, S., C. BEARD, R. JEANISCH, P. JONES, and J. SPRENT. 1997. Mitogenicity of DNA from different organisms for murine B cells. J. Immunol. 159: 3119.
11. KIMURA, Y., K. SONEHARA, E. KURAMOTO, T. MAKINO, S. YAMAMOTO, T. YAMAMOTO, T. KATAOKA, T. TOKUNAGA. 1994. Binding of oligoguanylate to scavenger receptors is required for oligonucletides to augment NK cell activity and induce IFN. J. Biochem. 116: 991.
12. PEARSON, A. M., A. RICH, and M. KRIEGER. 1993. Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices. J. Biol. Chem. 268: 3546.
13. BROWN, M. S., S. K. BASU, J. R. FALK, Y. K. Ho, and J. C. GOLDSTEIN. 1980. The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively charged LDL by macropahges. J. Supramol. Struct. 13: 67.
14. PISETSKY, D. S., and C. REICH. 1993. Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides. Mol. Biol. Reports 18: 217.
15. 3H-thymidine incorporation are related to position of thymidine residues in oligodeoxynucleotides. Exp. Hematology 22: 384.
16. HALPERN, M. D., R. J. KURLANDER, and D. S. PISETSKY. 1996. Bacterial DNA induces murine interferon-y production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell. Immunol. 167: 72.
17. KOBAYASHI, M., L. FRITZ, M. RYAN, R. M. HEWICK, S. C. CLARK, S. CHAN, R. LOUDON, F. SHERMAN, B. PERUSSIA, and G. TRINCHIERI. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827.
18. BALLAS, Z. K., W. L. RASMUSSEN, and A. M. KRIEG. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157: 1840.
19. KRIEGER, M. 1997. The other side of scavenger receptors: pattern recognition for host defense. Curr. Opin. Lipidology 8: 275.
20. WLOCH, M. K., S. PASQUINI, H. C. J. ERTL, and D. S. PISETSKY. 1998. The influence of DNA sequences on the immunostimulatory properties of plasmid DNA vectors. Hum. Gene Ther. 9: 1439.
21. ZABNER, J., A. J. FASBENDER, T. MONINGER, K. A. POELLINGER, and M. J. WELSH. 1995. Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biochim. 270: 18997.
22. SONEHARA, K., H. SAITO, E. KURAMOTO, S. YAMAMOTO, T. YAMAMOTO, and T. TOKUNAGA. 1996. Hexamer palindromic oligonucleotides with 5'-CG-3' motif(s) induce production of interferon. J. Interferon and Cytokine Res. 16: 799.
23. YAMAMOTO, S., T. YAMAMOTO, S. SHIMADA, E. KURAMOTO, O. YANO, T. KATAOKA, T. TOKUNAGA. 1992. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36: 983.
24. KLINMAN, D. M., A.-K. YI, S. L. BEAUCAGE, J. CONOVER, and A. M. KRIEG. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc. Natl. Acad. Sci. USA 93: 2879.
25. KRIEG, C., X. ZHANG, R. RATLIFF, R. MOYZIS, and A. RICH. 1992. Crystal structure of four stranded Oxytricha telomeric DNA. Nature 356: 126.
26. MONTIETH, D. K., S. P. HENRY, R. B. HOWARD, S. FLOURNOY, A. A. LEVIN, C. F. BENNETT, and S. T. CROOKE. 1997. Immune stimulation-a class effect of phosphorothioate oligodeoxynucleotides in rodents. Anti-Cancer Drug Design. 12: 421.
27. STEIN, C. A., C. SUBASINGHE, K. SHINOZUKA, and J. S. COHEN. 1988. Physiochemical properties of phosphorothioate oligodeoxynucleotides. Nucleic. Acids. Res. 16: 3209.
28. LIANG, H., Y. NISHIOKA, C. F. REICH, D. S. PISETSKY, and P. E. LIPSKY. 1996. Activation of human B cells by phosphorothioate oligodeoxynucleotides. J. Clin. Invest. 98: 1119.
29. ZELPHATI, O., and F. C. SZOKA. 1996. Mechanisms of oligonucleotide release from cationic liposomes. Proc. Natl. Acad. Sci. USA 93: 11493.
30. YAMAMOTO, T., S. YAMAMOTO, T. KATAOKA, T. TOKUNAGA. 1994. Lipofection of synthetic oligodeoxynucleotides having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity. Microbiol. Immunol. 38: 831.
31. MATZINGER, P. 1994. Tolerance, danger, and the extended family. Ann. Rev. Immunol. 12: 991.
32. DENLINGER, L. C., K. A. GARIS, J. A. SOMMER, A. G. GUADARRAMA, R. A. PROCTOR, and P. J. BERTICS. 1998. Nuclear translocation of NF-κB in lipopolysaccharide-treated macrophages fails to correspond to endotoxicity: evidence suggesting a requirement for a gamma interferon-like signal. Infect. Immun. 66: 1638.