Nuclear Translocation of NF-κB in Lipopolysaccharide-Treated Macrophages Fails to Correspond to Endotoxicity: Evidence Suggesting a Requirement for a Gamma Interferon-Like Signal

Infection and Immunity

Volumn 66, Issue 4, 1998, Pages 1638-1647

  Denlinger, Loren C ^a   Garis, Kristen A ^a   Sommer, Julie A ^a   Guadarrama, Arturo G ^a   Proctor, Richard A ^a   Bertics, Paul J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL NUCLEUS; LD 50; MACROPHAGE; MALE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL;

ADENOSINE DIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; INTERFERON TYPE II; LETHAL DOSE 50; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032038654     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.4.1638-1647.1998     Document Type: Article

References (41)

1. Al-Awqati, Q. 1995. Regulation of ion channels by ABC transporters that secrete ATP. Science 269:805-806.
2. Alley, E. W., W. J. Murphy, and S. W. Russell. 1995. A classical enhancer element responsive to both lipopolysaccharide and interferon-gamma augments induction of the iNOS gene in mouse macrophages. Gene 158:247-251.
3. Casey, L. C., R. A. Balk, and R. C. Bone. 1993. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann. Intern. Med. 119:771-778.
4. Delude, R. L., M. J. Fenton, R. Savedra, Jr., P.-Y. Perera, S. N. Vogel, R. Thieringer, and D. T. Golenbock. 1994. CD14-mediated translocation of nuclear factor-kB induced by lipopolysaccharide does not require tyrosine kinase activity. J. Biol. Chem. 269:22253-22260.
5. Delude, R. L., R. Savedra, Jr., H. Zhao, R. Thieringer, S. Yamamoto, M. J. Fenton, and D. T. Golenbock. 1995. CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc. Natl. Acad. Sci. USA 92:9288-9292.
6. Denlinger, L. C., P. L. Fisette, K. A. Garis, S. K. Daugherty, P. J. Bertics, and R. A. Proctor. 1996. Adenine nucleotides prevent endotoxicity and can influence LPS signal transduction, p. 227-252. In D. C. Morrison and J. L. Ryan (ed.), Novel therapeutic strategies in the treatment of sepsis. Marcel Dekker, Inc., New York, N.Y.
7. Denlinger, L. C., P. L. Fisette, K. A. Garis, G. Kwon, A. Vazquez-Torres, A. D. Simon, B. Nguyen, R. A. Proctor, P. J. Bertics, and J. A. Corbett. 1996. Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. J. Biol. Chem. 271:337-342.
8. Ding, A., S. Hwang, H. M. Lander, and Q. W. Xie. 1995. Macrophages derived from C3H/HeJ (Lpsd) mice respond to bacterial lipopolysaccharide by activating NF-kappa B. J. Leukocyte Biol. 57:174-179.
9. Dubyak, G. R., and C. El-Moatassim. 1993. Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol. 265:577-606.
10. Fujihara, M., N. Ito, J. L. Pace, Y. Watanabe, S. W. Russell, and T. Suzuki. 1994. Role of endogenous interferon-b in lipopolysaccharide-triggered activation of the inducible nitric oxide synthase gene in a mouse macrophage cell line, J774. J. Biol. Chem. 269:12773-12778.
11. Gallay, P., C. V. Jongeneel, C. Barras, M. Burnier, J. D. Baumgartner, M. P. Glauser, and D. Heumann. 1993. Short time exposure to lipopolysaccharide is sufficient to activate human monocytes. J. Immunol. 150:5086-5093.
12. Gegner, J. A., R. J. Ulevitch, and P. S. Tobias. 1995. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J. Biol. Chem. 270:5320-5325.
13. Goldfeld, A. E., C. Doyle, and T. Maniatis. 1990. Human tumor necrosis factor-α gene regulation by virus and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 87:9769-9773.
14. Han, J., T. Brown, and B. Beutler. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med. 171:465-475.
15. Haziot, A., E. Ferrero, F. Kontgen, N. Hijiya, S. Yamamoto, J. Silver, C. L. Stewart, and S. M. Goyert. 1996. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4:407-414.
16. Heinzel, F. P. 1990. The role of IFN-γ in the pathology of experimental endotoxemia. J. Immunol. 145:2920-2924.
17. Kato, N., M. Ohta, N. Kido, Y. Arakawa, H. Ito, and S. Naito. 1990. Inhibitory effect of Ca(2+) on formation of Mg(2+)-mediated two-dimensional hexagonal lattice structure by an R-form lipopolysaccharide from Klebsiella pneumoniae. Microbiol. Immunol. 34:427-438.
18. Kirikae, F., T. Kirikae, N. Qureshi, K. Takayama, D. C. Morrison, and M. Nakano. 1995. CD14 is not involved in Rhodobacter sphaeroides diphosphoryl lipid A inhibition of tumor necrosis factor alpha and nitric oxide induction by taxol in murine macrophages. Infect. Immun. 63:486-497.
19. Kitchens, R. L., and R. S. Munford. 1995. Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway. J. Biol. Chem. 270:9904-9910.
20. Kopp, E. B., and S. Ghosh. 1995. NF-kappa B and rel proteins in innate immunity. Adv. Immunol. 58:1-27.
21. Lawrence, O., N. Rachie, N. Qureshi, K. Bomsztyk, and C. H. Sibley. 1995. Diphosphoryl lipid A from Rhodobacter sphaeroides transiently activates NF-κB but inhibits lipopolysaccharide induction of kappa light chain and Oct-2 in the B-cell lymphoma line 70Z/3. Infect. Immun. 63:1040-1046.
22. Lehmann, V., M. A. Freudenberg, and C. Galanos. 1987. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J. Exp. Med. 165:657-663.
23. Lynn, W. A., and D. T. Golenbock. 1992. Lipopolysaccharide antagonists. Immunol. Today 13:271-276.
24. MacMicking, J. D., C. Nathan, G. Hom, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q. Xie, K. Sokol, N. Hutchinson, H. Chen, and J. S. Mudgett. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650.
25. Proctor, R. A., L. C. Denlinger, and P. J. Bertics. 1995. Lipopolysaccharide and bacterial virulence, p. 173-194. In J. A. Roth, C. A. Bolin, K. A. Brogden, F. C. Minion, and M. J. Wannemuehler (ed.), Virulence mechanisms of bacterial pathogens, 2nd ed. ASM Press, Washington, D.C.
26. Proctor, R. A., L. C. Denlinger, P. S. Leventhal, S. K. Daugherry, J.-W. van de Loo, T. Tanke, G. S. Firestein, and P. J. Bertics. 1994. Protection of mice from endotoxic death by 2-methylthio-ATP. Proc. Natl. Acad. Sci. USA 91: 6017-6020.
27. Proctor, R. A., J. A. Will, K. E. Burhop, and C. R. H. Raetz. 1986. Protection of mice against lethal endotoxemia by a lipid A precursor. Infect. Immun. 52: 905-907.
28. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27:493-497.
29. Rietschel, E. T., T. Kirikae, F. U. Schade, U. Mamat, G. Schmidt, H. Loppnow, A. J. Ulmer, U. Zahringer, U. Seydel, F. de Padova, M. Schreir, and H. Brade. 1994. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8:217-225.
30. Seydel, U., H. Labischinski, M. Kastowsky, and K. Brandenburg. 1993. Phase behavior, supramolecular structure, and molecular conformation of lipopolysaccharide. Immunobiology 187:191-211.
31. Shi, Y., H. Q. Li, C. K. Shen, J. H. Wang, S. W. Qin, R. Liu, and J. Pan. 1993. Plasma nitric oxide levels in newborn infants with sepsis. J. Pediatr. 123: 435-438.
32. Snedecor, G. W., and W. G. Cochran. 1989. Statistical methods, 8th ed. Iowa State University Press, Ames.
33. Sweet, M. J., and D. A. Hume. 1996. Endotoxin signal transduction in macrophages. J. Leukocyte Biol. 60:8-26.
34. Takayama, K., D. H. Mitchell, Z. Z. Din, P. Mukerjee, C. Li, and D. L. Coleman. 1994. Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amoebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages. J. Biol. Chem. 269:2241-2244.
35. Tanke, T., J.-W. van de Loo, H. Rhim, P. S. Leventhal, R. A. Proctor, and P. J. Bertics. 1991. Bacterial lipopolysaceharide-stimulated GTPase activity in RAW264.7 macrophage membranes. Biochem. J. 277:379-385.
36. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. 1 kappa-B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell 80:573-582.
37. Ulevitch, R. J., and P. S. Tobias. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13:437-457.
38. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
39. Xie, Q., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705-4708.
40. Zähringer, U., B. Lindner, and E. T. Rietschel. 1994. Molecular structure of lipid A, the endotoxic center of bacterial lipopolysaccharides. Adv. Carbohydr. Chem. Biochem. 50:211-276.
41. Zhang, X., E. W. Alley, S. W. Russell, and D. C. Morrison. 1994. Necessity and sufficiency of beta interferon for nitric oxide production in mouse peritoneal macrophages. Infect. Immun. 62:33-40.