Structure and regulation of the human NeuroD (BETA2/BHF1) gene

Molecular Brain Research

Volumn 69, Issue 2, 1999, Pages 223-231

  Miyachi, Takafumi ^a   Maruyama, Hirofumi ^a   Kitamura, Takeshi ^a   Nakamura, Shigenobu ^a   Kawakami, Hideshi ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoactivation; Basic helix loop helix; NeuroD (BETA2 BHF1); Neuronal development; Promoter

Indexed keywords

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DNA SEQUENCE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; HAMSTER; HUMAN; HUMAN CELL; KIDNEY CELL; MOLECULAR CLONING; MONKEY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; CONSENSUS SEQUENCE; CRICETINAE; EXONS; GENE EXPRESSION REGULATION; GENETIC VECTORS; HELIX-LOOP-HELIX MOTIFS; HUMANS; INTRONS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

CRICETINAE;

EID: 0032982903     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00112-6     Document Type: Article

References (40)

1. Akazawa C., Sasai Y., Nakanishi S., Kageyama R. Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J. Biol. Chem. 267:1992;21879-21885.
2. Bang A.G., Goulding M.D. Regulation of vertebrate neural cell fate by transcription factors. Curr. Opin. Neurobiol. 6:1996;25-32.
3. Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 61:1990;49-59.
4. Breathnach R., Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50:1981;349-383.
5. Dechesne C.A., Wei Q., Eldridge J., Gannoun Zaki L., Millasseau P., Bougueleret L., Caterina D., Paterson B.M. E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol. Cell. Biol. 14:1994;5474-5486.
6. Edmondson D.G., Cheng T.C., Cserjesi P., Chakraborty T., Olson E.N. Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2. Mol. Cell. Biol. 12:1992;3665-3677.
7. Graham F.L., van der Eb A.J. Transformation of rat cells by DNA of human adenovirus 5. Virology. 54:1973;536-539.
8. Ishibashi M., Moriyoshi K., Sasai Y., Shiota K., Nakanishi S., Kageyama R. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. EMBO J. 13:1994;1799-1805.
9. Kawakami H., Maruyama H., Yasunami M., Ohkubo H., Hara H., Saida T., Nakanishi S., Nakamura S. Cloning and expression of a rat brain basic helix-loop-helix factor. Biochem. Biophys. Res. Commun. 221:1996;199-204.
10. Kawakami H., Moriyoshi K., Utsumi T., Nakanishi S. Structural organization and expression of the gene for bovine myosin I heavy chain. J. Biochem. Tokyo. 111:1992;302-309.
11. King P.H. Cloning the 5′ flanking region of neuron-specific Hel-N1: evidence for positive regulatory elements governing cell-specific transcription. Brain Res. 723:1996;141-147.
12. T. Kitamura, T. Miyachi, S. Nakamura, H. Kawakami, Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF), Biochim. Biophys. Acta, in press.
13. Lee J.E. Basic helix-loop-helix genes in neural development. Curr. Opin. Neurobiol. 7:1997;13-20.
14. Lee J.E. NeuroD and neurogenesis. Dev. Neurosci. 19:1997;27-32.
15. Lee J.E., Hollenberg S.M., Snider L., Turner D.L., Lipnick N., Weintraub H. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 268:1995;836-844.
16. Maruyama K., Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138:1994;171-174.
17. McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. Mol. Cell. Biol. 16:1996;5792-5800.
18. Murre C., McCaw P.S., Vaessin H., Caudy M., Jan L.Y., Jan Y.N., Cabrera C.V., Buskin J.N., Hauschka S.D., Lassar A.B., Weintraub H., Baltimore D. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 58:1989;537-544.
19. Mutoh H., Fung B.P., Naya F.J., Tsai M.J., Nishitani J., Leiter A.B. The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc. Natl. Acad. Sci. USA. 94:1997;3560-3564.
20. Naya F.J., Huang H.P., Qiu Y., Mutoh H., DeMayo F.J., Leiter A.B., Tsai M.J. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11:1997;2323-2334.
21. Naya F.J., Stellrecht C.M., Tsai M.J. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9:1995;1009-1019.
22. Niwa H., Yamamura K., Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108:1991;193-199.
23. Olson E.N., Klein W.H. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev. 8:1994;1-8.
24. Ozaki T., Enomoto H., Nakamura Y., Kondo K., Seki N., Ohira M., Nomura N., Ohki M., Nakagawara A., Sakiyama S. The genomic analysis of human DAN gene. DNA Cell. Biol. 16:1997;1031-1039.
25. Peyton M., Stellrecht C.M., Naya F.J., Huang H.P., Samora P.J., Tsai M.J. BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes. Mol. Cell. Biol. 16:1996;626-633.
26. Poulin G., Turgeon B., Drouin J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol. Cell. Biol. 17:1997;6673-6682.
27. Rostomily R.C., Bermingham McDonogh O., Berger M.S., Tapscott S.J., Reh T.A., Olson J.M. Expression of neurogenic basic helix-loop-helix genes in primitive neuroectodermal tumors. Cancer Res. 57:1997;3526-3531.
28. Sachs A.B. Messenger RNA degradation in eukaryotes. Cell. 74:1993;413-421.
29. J. Sambrook, E.F. Fritsch, T. Maniatis (Eds.), Molecular Cloning: A Laboratory Manual, 2nd edn., Cold Spring Harbor Laboratory Press, NY, 4 21-24, 1989, 32 pp.
30. Schwab M.H., Druffel Augustin S., Gass P., Jung M., Klugmann M., Bartholomae A., Rossner M.J., Nave K.A. Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J. Neurosci. 18:1998;1408-1418.
31. Suzuki Y., Yoshitomo Nakagawa K., Maruyama K., Suyama A., Sugano S. Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library. Gene. 200:1997;149-156.
32. Thayer M.J., Tapscott S.J., Davis R.L., Wright W.E., Lassar A.B., Weintraub H. Positive autoregulation of the myogenic determination gene MyoD1. Cell. 58:1989;241-248.
33. Tomatsu S., Kobayashi Y., Fukumaki Y., Yubisui T., Orii T., Sakaki Y. The organization and the complete nucleotide sequence of the human NADH-cytochrome b5 reductase gene. Gene. 80:1989;353-361.
34. Wahle E., Keller W. The biochemistry of 3′-end cleavage and polyadenylation of messenger RNA precursors. Annu. Rev. Biochem. 61:1992;419-440.
35. Weintraub H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell. 75:1993;1241-1244.
36. Weintraub H., Davis R., Tapscott S., Thayer M., Krause M., Benezra R., Blackwell T.K., Turner D., Rupp R., Hollenberg S., Zhuang Y., Lassar A. The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 251:1991;761-766.
37. Xu W., Murphy L.J. Isolation and characterization of the mouse beta 2/neuroD gene promoter. Biochem. Biophys. Res. Commun. 247:1998;814-818.
38. Yasunami M., Suzuki K., Maruyama H., Kawakami H., Nagai Y., Hagiwara M., Ohkubo H. Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem. Biophys. Res. Commun. 220:1996;754-758.
39. Yu Y.S., Suzuki Y., Yoshitomo K., Muramatsu M., Yamaguchi N., Sugano S. The promoter structure of TGF-beta type II receptor revealed by 'oligo-capping' method and deletion analysis. Biochem. Biophys. Res. Commun. 225:1996;302-306.
40. Zingg J.M., Pedraza Alva G., Jost J.P. MyoD1 promoter autoregulation is mediated by two proximal E-boxes. Nucleic Acids Res. 22:1994;2234-2241.