Natural autoantibodies, tolerance, and autoimmunity

Annals of the New York Academy of Sciences

Volumn 815, Issue , 1997, Pages 182-192

  Dighiero, G ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL CELL; AUTOIMMUNITY; B LYMPHOCYTE; CONFERENCE PAPER; ETIOLOGY; HISTORY OF MEDICINE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN;

ANIMALIA;

EID: 0030792869     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52059.x     Document Type: Conference Paper

References (86)

1. METCHNIKOFF, S. 1900. Etudes sur la spermatoxine. Ann. Inst. Pasteur 9: 577.
2. BESREDKA, M. 1901. Les anti-hémolysines naturelles. Ann. Inst. Pasteur 15: 785.
3. EHRLICH, P. & J. MORGENROTH. 1957. On haemolysins: third communication. In The Collected Papers of Paul Ehrlich. Volume 2, p. 205-212. Pergamon, London.
4. EHRLICH, P. & J. MORGENROTH. 1957. On haemolysins: fifth communication. In The Collected Papers of Paul Ehrlich. Volume 2, p. 246-255. Pergamon. London.
5. LANDSTEINER, K. 1900. The Specificity of Serological Reactions. Volume 27, p. 357-371. Harvard University Press. Cambridge, Massachusetts.
6. DONATH, J. & K. LANDSTEINER, 1904. Uber paroxysmale hamoglobinurie. Munch. Med. Wochenschr. 51: 1590-1595.
7. BURNET, F. M. & F. FENNER. 1949. The Production of Antibodies. Macmillan & Co. London.
8. OWEN, R. D. 1945. Immunogenetic consequences of vascular anastomoses between bovine cattle twins. Science 102: 400-404.
9. BILLINGHAM, R. E., L. BRENT & P. B. MEDAWAR. 1953. Actively acquired tolerance of foreign cells. Nature 172: 603.
10. BURNET, F. M. 1959. The Clonal Selection Theory of Acquired Immunity. Cambridge University Press. London/New York.
11. ROSE, N. R. & E. WITEBSKY. 1956. Studies on organ specificity: V changes in the thyroid glands of rabbits following acute immunization with rabbit thyroid extracts. J. Immunol. 76: 417-428.
12. HOOPER, B., S. WHITTINGHAM & J. D. MATHEWS. 1972. Autoimmunity in a rural community. Clin. Immunol. 12: 79-87.
13. MACKAY, I. R. 1983. Natural autoantibodies to the fore-forbidden clones to the rear? Immunol. Today 4: 340-342.
14. IZUI, S., P. H. LAMBERT & G. L. FOUNIE. 1977. Features of systemic lupus erythematosus in mice infected with bacterial lipopolysaccharides. J. Exp. Med. 145: 1115-1128.
15. GUILBERT, B., G. DIGHIERO & S. AVRAMEAS. 1982. Naturally occurring antibodies against nine common antigens in normal humans. I. Detection, isolation, and characterization. J. Immunol. 128: 2779-2787.
16. LUTZ, H. U. & G. WIPF. 1982. Naturally occurring auto-antibodies to skeletal proteins from human red blood cells. J. Immunol. 128: 1695-1701.
17. MARTIN, S. E. & W. J. MARTIN. 1975. Interspecies brain antigen detected by naturally occurring mouse anti-brain auto-antibody. Proc. Natl. Acad. Sci. U.S.A. 72: 1036-1041.
18. MARTIN, W. J. & S. E. MARTIN. 1975. Thymus reactive IgM auto-antibodies in normal mouse sera. Nature 254: 716-718.
19. WALFORD, R. L. 1969. The Immunologic Theory of Aging. Munksgaard. Copenhagen.
20. SELA, B. A., J. L. WANG & G. M. EDELMAN. 1975. Antibodies reactive with cell surface carbohydrates. Proc. Natl. Acad. Sci. U.S.A. 72: 1127-1132.
21. DIGHIERO, G., P. LYMBERI, B. GUILBERT, T. TERNYNCK & S. AVRAMEAS. 1986. Natural autoantibodies constitute a substantial part of normal circulating immunoglobulins. Ann. N. Y. Acad. Sci. 475: 135-145.
22. DIGHIERO, G., P. LYMBERI, J. C. MAZIÉ, S. ROUYRE, G. S. BUTLER-BROWNE, R. G. WHALEN & S. AVRAMEAS. 1983. Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J. Immunol. 131: 2267-2272.
23. DIGHIERO, G., P. LYMBERI, D. HOLMBERG, I. LUNDQUIST, A. COUTINHO & S. AVRAMEAS. 1985. High frequency of natural autoantibodies in normal newborn mice. J. Immunol. 134: 765-771.
24. MONIER, J. C., J. BROCHIER, A. MOREIRA, C. SAULT & B. ROUX. 1984. Generation of hybridoma antibodies to double-stranded DNA from non-autoimmune BALB/c strain: studies on anti-idiotype. Immunol. Lett. 8: 61-68.
25. PRABHAKAR, B. S., J. SAEGUSA, T. ONODERA & A. L. NOTKINS. 1984. Lymphocytes capable of making monoclonal autoantibodies that react with multiple organs are a common feature of the normal B cell repertoire. J. Immunol. 133: 2815-2817.
26. RAUCH, J., E. MURPHY, J. B. ROTHS, B. D. STOLLAR & R. S. SCHWARTZ. 1982. A high frequency idiotypic marker of anti-DNA autoantibodies in MR-lpr/lpr mice. J. Immunol. 129: 236-241.
27. TRON, F., C. L. LE GUERN, P. A. CAZENAVE & J. F. BACH. 1982. Intrastrain recurrent idiotypes among anti-DNA antibodies of (NZB/NZW)F1 hybrid mice. Eur. J. Immunol. 12: 761-766.
28. MARION, T. N., A. R. LAWTON, J. F. KEARNEY & D. E. BRILES. 1982. Anti-DNA autoantibodies in (NZB × NZW)F1 mice are clonally heterogeneous, but a majority share a common idiotype. J. Immunol. 128: 668-674.
29. ISENBERG, D. A., Y. SHOENFELD, M. R. MADAIO, J. RAUCH, M. REICHLIN & B. D. STOLLAR. 1983. Z-DNA specific antibodies in human systemic lupus erythematosus. J. Clin. Invest. 71: 314-321.
30. HOLMBERG, D., S. FORSGREN, F. IVARS & A. COUTINHO. 1984. Reactions among IgM antibodies derived from normal, neonatal mice. Eur. J. Immunol. 14: 435-440.
31. LYMBERI, P., G. DIGHIERO, T. TERNYNCK & S. AVRAMEAS. 1985. A high incidence of cross-reactive idiotypes among murine natural autoantibodies. Eur. J. Immunol. 15: 702-707.
32. MATTHES, T. & G. DIGHIERO. 1988. Detection of private and recurrent idiotopes on natural anti-tubulin antibodies by monoclonal anti-idiotopic antibodies. J. Immunol. 140: 148-154.
33. SHOENFELD, Y., S. C. HSU-LIN, J. E. GABRIELS, L. E. SILBERSTEIN, B. C. FURIE, B. D. STOLLAR & R. S. SCHWARTZ. 1982. Production of autoantibodies by human-human hybridomas. J. Clin. Invest. 70: 205-208.
34. SHOENFELD, Y., J. RAUCH, H. MASSICOTTE, S. K. DATTA, J. ANDRÉ-SCHWARTZ, B. D. STOLLAR & R. S. SCHWARTZ. 1983. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N. Engl. J. Med. 308: 414-420.
35. SATOH, J., B. S. PRABHAKAR, M. V. HASPEL, F. GINSBERG-FELLNER & A. L. NOTKINS. 1983. Human monoclonal autoantibodies that react with multiple endocrine organs. N. Engl. J. Med. 309: 217-220.
36. HASPEL, M. V., T. ONODERA, B. S. PRABHAKAR, K. E. MCCLINTOCK, U. R. RAY, S. YAGIHASHI & A. L. NOTKINS. 1983. Multiple organ-reactive monoclonal autoantibodies. Nature 304: 74-76.
37. CAIRNS, E., J. BLOCK & D. A. BELL. 1984. Anti-DNA autoantibody producing hybridomas of normal human lymphoid cell origin. J. Clin. Invest. 74: 880-887.
38. DIGHIERO, G., P. PONCET, S. ROUYRE & J. C. MAZIÉ. 1986. Newborn Xid mice carry the genetic information for the production of natural autoantibodies. J. Immunol. 136: 4000-4006.
39. HASKARD, D. O., V. GUL, A. MORGAN, P. KATAAHA, N. A. STAINES & J. R. ARCHER. 1985. Human monoclonal autoantibodies from patients with rheumatoid arthritis against cellular constituents. Clin. Exp. Immunol. 61: 496-502.
40. DIGHIERO, G. 1995. Natural autoantibodies in humans: their relevance in autoimmunity and lymphoproliferative disorders. Forum Trends Exp. Clin. Med. 5: 58-71.
41. GONZALES, R., J. CHARLEMAGNE, W. MAHANA & S. AVRAMEAS. 1988. Specificity of natural serum antibodies present in phylogenetically distinct fish species. Immunology 63: 31-36.
42. NEMAZEE, D. & K. BURKI. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class antibody genes. Nature 337: 562-566.
43. NEMAZEE, D. 1995. Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory. Ann. N.Y. Acad. Sci. 764: 397-401.
44. GOODNOW, C. C., R. BRINK & E. ADAMS. 1991. Breakdown of self-tolerance in anergic B lymphocytes. Nature 352: 532-536.
45. RATHMELL, J. C. & C. C. GOODNOW. 1995. Autoimmunity: the Fas track. Curr. Biol. 5(11): 1218-1221.
46. ERIKSON, J., M. Z. RADIC, S. A. CAMPER, R. R. HARDY, C. CARMACK & M. WEIGERT. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349: 331-335.
47. LAFER, E. M., J. RAUCH, C. ANDRZEWSKI, D. MUDD, B. FURIE, R. S. SCHWARTZ & B. D. STOLLAR. 1981. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J. Exp. Med. 153: 897-909.
48. DIGHIERO, G., B. GUILBERT & S. AVRAMEAS. 1982. Naturally occurring antibodies against nine common antigens in human sera: II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies. J. Immunol. 128: 2788-2792.
49. DIGHIERO, G., B. GUILBERT, J. P. FERMANT, P. LYMBERI, F. DANON & S. AVRAMEAS. 1983. Thirty-six human monoclonal immunoglobulins (MIg) with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunological studies and clinical correlations. Blood 62: 264-270.
50. ANDRÉ-SCHWARTZ, J., S. K. DATTA, Y. SHOENFELD, D. A. ISENBERG, B. D. STOLLAR & R. S. SCHWARTZ. 1984. Binding of cytoskeletal proteins by monoclonal anti-DNA lupus autoantibodies. Clin. Immunol. Immunopathol. 31: 261-271.
51. RAUCH, J., H. TANNENBAUM, B. D. STOLLAR & R. S. SCHWARTZ. 1984. Monoclonal anticardiolipin antibodies bind to DNA. Eur. J. Immunol. 14: 529-534.
52. JACOB, L., F. TRON, J. F. BACH & D. LOUVARD. 1984. A monoclonal anti-DNA antibody also binds to cell surface proteins. Proc. Natl. Acad. Sci. U.S.A. 81: 3843-3845.
53. PONCET, P., T. MATTHES, A. BILLECOCQ & G. DIGHIERO. 1988. Immunochemical studies of polyspecific natural autoantibodies: charge lipid reactivity, Fab'2 fragments activity, and complement fixation. Mol. Immunol. 25: 981-989.
54. AMIT, A. G., R. A. MARIUZZA, S. E. PHILLIPS & R. J. POLJAK. 1986. Three-dimensional structure of an antigen-antibody complex at 2.8-A resolution. Science 233: 747-753.
55. BACCALA, R., T. V. QUANG, M. GILBERT, T. TERNYNCK & S. AVRAMEAS. 1989. Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc. Natl. Acad. Sci. U.S.A. 86: 4624-4628.
56. LESCAR, J., M. PELLEGRINI, H. SOUCHON, D. TELLO, R. J. POLJAK, N. PETERSON, M. GREENE & P. M. ALZARI. 1995. Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme. J. Biol. Chem. 270: 18067-18073.
57. BENTLEY, G. A., G. BOULOT, M. M. RIOTTOT & R. J. POLJAK. 1990. Three-dimensional structure of an idiotope-anti-idiotope complex. Nature 348: 254-260.
58. DU PASQUIER, L. 1993. Evolution of the immune system. In William Paul Fundamental Immunology. Third edition, p. 199-235. Raven Press. New York.
59. BOS, N. A., C. G. MEENSWEN, H. HOOIJKAAS, R. BENNER, B. S. WOSTMAN & J. R. PLEASANTS. 1987. Early development of Ig secreting cells in young of germ Balb mice fed a chemically defined ultrafiltered diet. Cell. Immunol. 105: 235-245.
60. KOFLER, R., D. I. NOONARS, D. E. LEVY, M. C. WILSON, N. P. H. MOLLER, F. J. DIXON & A. N. THEOFILOPOULOS. 1985. Genetic elements utilized for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens. J. Exp. Med. 161: 805-815.
61. TREPICCHIO, W., JR., A. MARUYA & K. J. BARRETT. 1987. The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germline of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus. J. Immunol. 139: 3139-3147.
62. AGUADO, M. T., R. S. BALDERAS, R. L. RUBIN, M. A. DUCHOSAL, R. KOFLER, B. K. BIRSHTEIN, D. S. SECHER, F. J. DIXON & A. N. THEOFILOPOULOS. 1987. Specificity and molecular characteristics of monoclonal IgM rheumatoid factors from arthritic and nonarthritic mice. J. Immunol. 139: 1080-1089.
63. H families. J. Immunol. 142: 4054-4061.
64. KOFLER, R., F. J. DIXON & A. N. THEOFILOPOULOS. 1987. The genetic origin of autoantibodies. Immunol. Today 8: 374-379.
65. H gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus. J. Exp. Med. 164: 614-626.
66. GUILBERT, B., W. MAHANA, M. GILBERT, J. C. MAZIÉ & S. AVRAMEAS. 1985. Presence of natural autoantibodies in hyperimmunized mice. Immunology 56: 401-408.
67. DZIARSKI, R. 1988. Autoimmunity: polyclonal activation or antigen induction? Immunol. Today 9: 340-342.
68. KLINMAN, D. & A. D. STEINBERG. 1987. Systemic autoimmune disease arises from polyclonal B-cell activation. J. Exp. Med. 165: 1755-1760.
69. SHLOMCHIK, M. J., A. MARSHAK-ROTHSTEIN, C. B. WOLFOWICZ, T. L. ROTHSTEIN & M. G. WEIGERT. 1987. The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805-811.
70. SHLOMCHIK, M. J., A. H. AUCOIN, D. S. PISETSKY & M. G. WEIGERT. 1987. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc. Natl. Acad. Sci. U.S.A. 84: 9150-9154.
71. THEOFILOPOULOS, A. N. & F. J. DIXON. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37: 269-290.
72. SCHWARTZ, R. S. & B. D. STOLLAR. 1985. Origins of anti-DNA autoantibodies. J. Clin. Invest. 75: 321-325.
73. CUNNINGHAM, A. J. 1974. Large numbers of cells in normal mice produce antibody components of isologous erythrocytes. Nature 252: 749-751.
74. IZUI, S., N. M. ZALDIVAR, I. SCHER & P. H. LAMBERT. 1977. Mechanism for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice. I. Anti-DNA induction by LPS without significant release of DNA in circulating blood. J. Immunol. 119: 2151-2160.
75. PLAYFAIR, J. H. 1982. Immunity to malaria. Br. Med. Bull. 38: 153-156.
76. KAZYUMBA, G., M. BERNEY & G. BRIGHOUSE. 1986. Expression of the B cell repertoire and autoantibodies in human African trypanosomiasis. Clin. Exp. Immunol. 65: 10-16.
77. BEHAR, S. M., D. L. LUSTGARTEN, S. CORBET & M. D. SCHARFF. 1980. Characterization of somatically mutated S10è VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB × NZW) F1 mice. J. Exp. Med. 148: 1198-1213.
78. MARION, T. N., A. L. M. BOTHWELL, D. E. BRILES & C. J. JANEWAY. 1989. IgG DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J. Immunol. 142: 4269-1278.
79. MARION, T. N., D. M. TILLMAN & N. T. JOU. 1990. Interclonal and intraclonal diversity among anti-DNA antibodies from an (NZB × NZW) F1 mouse. J. Immunol. 145: 2322.
80. O'KEEFE, T. L., S. BANDYOPADHYAY, S. K. DATTA & T. IMANISHI-KARI. 1990. V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies. J. Immunol. 144: 4275-4282.
81. RADIC, M. Z., M. A. MASCELLI, J. ERIKSON, H. SHAN, M. SHLOMCHIK & M. WEIGERT. 1989. Structural patterns in anti-DNA antibodies from MRL/lpr mice. Cold Spring Harbor Symp. Quant. Biol. 54: 993-1001.
82. SMITH, R. G. & E. W. Voss, JR. 1990. Variable region primary structures of monoclonal anti-DNA autoantibodies from (NZB × NZW) F1 mouse. Mol. Immunol. 27: 463-471.
83. MARION, T. N., D. M. TILLMAN, N. T. JOU & R. J. HILL. 1992. Selection of immunoglobulin variable regions in autoimmunity to DNA. Immunol. Rev. 128: 123-150.
84. RANDEN, I., K. M. THOMPSON, S. J. THORPE, O. FORRE & J. B. NATVIG. 1993. Human monoclonal IgG rheumatoid factors from the synovial tissue of patients with rheumatoid arthritis. Scand. J. Immunol. 37: 668-672.
85. STEWART, A. K., C. HUANG, A. A. LONG, B. D. STOLLAR & R. S. SCHWARTZ. 1992. VH-gene representation in autoantibodies reflects the normal human B-cell repertoire. Immunol. Rev. 128: 101-122.
86. HUANG, C., A. K. STEWART, R. S. SCHWARTZ & B. D. STOLLAR. 1992. Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes. J. Clin. Invest. 89: 1331-1343.