An influenza A live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters

Vaccine

Volumn 15, Issue 12-13, 1997, Pages 1372-1378

  Murphy, Brian R ^a   Park, Eun Ju ^a   Gottlieb, Paul ^a   Subbarao, Kanta ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Influenza virus; PB2 gene; Temperature sensitive mutants; Vaccine

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; INFLUENZA VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; GENETIC ANALYSIS; GENETIC TRANSFECTION; GENOTYPE; HAMSTER; IMMUNOGENICITY; INFLUENZA VIRUS A; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TEMPERATURE SENSITIVE MUTANT; TEMPERATURE SENSITIVITY; VIRUS CULTURE; VIRUS REPLICATION;

ANIMALS; CERCOPITHECUS AETHIOPS; CHICKENS; CRICETINAE; FEMALE; INFLUENZA A VIRUS; INFLUENZA VACCINES; MESOCRICETUS; MUTATION; TEMPERATURE; TRANSFECTION; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0030920478     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00031-5     Document Type: Article

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