A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene

Molecular and Cellular Endocrinology

Volumn 134, Issue 2, 1997, Pages 147-156

  Michael, M Dodson ^a   Michael, Laura F ^a   Simpson, Evan R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

cAMP dependent regulation; CREB; Human aromatase

Indexed keywords

AROMATASE; CELL NUCLEUS RECEPTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450; CYTOSINE; FOLLITROPIN; LEUCINE ZIPPER PROTEIN; OLIGONUCLEOTIDE; PALINDROMIC DNA; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; NONHUMAN; OVARY; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

ANIMALS; AROMATASE; BASE SEQUENCE; CATTLE; CELL LINE; CORPUS LUTEUM; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; FORSKOLIN; HUMANS; LUCIFERASES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC;

EID: 0030777797     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)00178-0     Document Type: Article

References (32)

1. Akhtar M., Njar V.C.O., Wright J.N. Mechanistic studies on aromatase and related C-C bond cleaving P450 enzymes. J. Steroid Biochem. Mol. Biol. 44:1993;375-387.
2. Begeot M., Shetty U., Kilgore M.W., Waterman M.R., Simpson E.R. Regulation of expression of the CYP11A (P450scc) gene in bovine ovarian luteal cells by forskolin and phorbol esters. J. Biol. Chem. 268:1993;17317-17325.
3. Bhattacharya, S., Eckner, R., Grossman, S., Oldread, E., Arany, Z., D'Andrea, A., Livingston, D., 1996. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-?. Nature 344-347.
4. Carlone, D., Richards, J., 1997. Functional interactions phosphorylation and levels of 3′,5′-cyclic adenosine monophosphate-regulatory element binding protein and steroidogenic factor-1 mediate hormone-regulated and constitutive expression of aromatase in gonadal cells. Mol. Endocrinol. 292-304.
5. Carr, B.R., 1992, Disorders of the ovary and female reproductive tract. In: Wilson, J.D., Foster, D.W., Saunders, W.B. (Eds.), Williams Textbook of Endocrinology, Philadelphia, pp. 733-798.
6. Caspi E., Wicha J., Arunachalam T., Nelson P., Spiteller G. Estrogen biosynthesis. Concerning the obligatory intermediacy of 2?-hydroxy-10?-formylandrost-4-ene-3,17-dione. J. Am. Chem. Soc. 106:1984;7282-7283.
7. Chrivia J.C., Kwok R.P., Lamb N., Hagiwara M., Montininy M.R., Goodman R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 365:1993;855-859.
8. Cole P.A., Robinson C.H. A peroxide model reaction for placental aromatase. J. Am. Chem. Soc. 110:1988;1284-1285.
9. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
10. Fitzpatrick S.L., Richards J.S. Identification of a cyclic adenosine 3′,5′-monophosphate-response element in the rat aromatase promoter that is required for transcriptional activation in rat granulosa cells and R2C leydig cells. Mol. Endocrinol. 8:1994;1309-1319.
11. Gonzalez G.A., Menzel P., Leonard J., Fischer W.H., Montminy M.R. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol. Cell Biol. 11:1991;1306-1312.
12. Goto J., Fishman J. Participation of a non-enzymatic transformation in the biosynthesis of estrogens from androgens. Science. 195:1977;80-81.
13. Harada N., Yamada K., Saito K., Kibe N., Dohmae S., Takagi Y. Structural characterization of the human estrogen synthetase (aromatase) gene. Biochem. Biophys. Res. Commun. 166:1990;365-372.
14. Hinshelwood, M.M., Michael, M.D., Simpson, E.R., 1997. The 5′-flanking region of the ovarian promoter of the bovine CYP19 gene contains a mutation in a cAMP-like responsive sequence (CLS). Endocrinology, submitted.
15. Jenkins C., Michael D., Mahendroo M., Simpson E. Exon-specific northern analysis and rapid amplification of cDNa ends (RACE) reveal that the proximal promoter II (PH) is responsible for aromatase cytochrome P450 (CYP19) expression in human ovary. Mol. Cell. Endocrinol. 97:1993;R1-R6.
16. Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S., Heyman, R., Rose, D., Glass, C., Rosenfeld, M., 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell, 403-414.
17. Kwok, R., Lundblad, J., Chrivia, J., Richards, J., Bachinger, H., Brennan, R., Roberts, S., Green, M., Goodman, R., 1994. Nuclear receptor CBP is a coactivator for the transcription factor CREB. Nature, 223-226.
18. Lauber M.E., Kagawa N., Waterman M.R., Simpson E.R. cAMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture. Mol. Cell. Endocrinol. 93:1993;227-233.
19. McAllister J.M., Mason J.I., Byrd W., Trant J.M., Waterman M.R., Simpson E.R. Proliferating human granulosa-lutein cells in long-term monolayer culture: expression of aromatase, cholesterol side chain cleavage and 3?-hydroxysteroid dehydrogenase. J. Clin. Endocrinol. Metab. 71:1990;26-33.
20. McAllister J.M., Byrd W., Simpson E.R. The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture. J. Clin. Endocrinol. Metab. 79:1994;106-112.
21. Means G.D., Mahendroo M., Corbin C.J., Mathis J.M., Powell F.E., Mendelson C.R., Simpson E.R. Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem. 264:1989;19385-19391.
22. Means G.D., Kilgore M.W., Mahendroo M.S., Mendelson C.R., Simpson E.R. Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5:1991;2005-2013.
23. Meyer T.E., Habener J.F. Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr. Rev. 14:1993;269-290.
24. Michael M.D., Kilgore M.W., Morohashi K.-I., Simpson E.R. Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J. Biol. Chem. 270:1995;13466-13561.
25. Michael, L., Alcorn, J., Gao, E., Mendelson, C., 1996. Characterization of the cyclic adenosine 3′,5′-monophosphate response element of the rabbit surfactant protein-A gene: evidence for transactivators distinct from CREB/ATF family members. Mol. Endocrinol. 159-170.
26. Simpson E.R., Mahendroo M.S., Means G.D., Kilgore M.W., Hinshelwood M.M., Graham-Lorence S., Amarneh B., Ito Y., Fisher C.R., Michael M.D., Mendelson C.R., Bulun S.E. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr. Rev. 15:1994;342-355.
27. arom) in human granulosa cells. Mol. Endocrinol. 1:1987;465-471.
28. Steinkampf M.P., Mendelson C.R., Simpson E.R. Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P450 of human ovarian granulosa cells. Mol. Cell. Endocrinol. 59:1988;93-99.
29. Stirling D., Magness R.R., Stone R., Waterman M.R., Simpson E.R. Angiotensin II inhibits LH-stimulated cholesterol side-chain cleavage expression and stimulates basic fibroblast growth factor expression in bovine luteal cells in primary culture. J. Biol. Chem. 265:1990;5-8.
30. Thompson E.A. Jr., Siiteri P.K. Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. J. Biol. Chem. 249:1974;5364.
31. Toda K., Terashima M., Kamamoto T., Sumimoto H., Yamamoto Y., Sagara Y., Ikeda H., Shizuta Y. Structural and functional characterization of human aromatase P450 gene. Eur. J. Biochem. 193:1990;559-565.
32. Westin G., Gerster T., MÜller M.M., Schaffner G., Schaffner W. OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res. 15:1987;6787-6798.