Human Diseases with Defects in Oxidative Phosphorylation: 2. F1F0 ATP‐Synthase Defects in Alzheimer Disease Revealed by Blue Native Polyacrylamide Gel Electrophoresis

European Journal of Biochemistry

Volumn 227, Issue 3, 1995, Pages 916-921

  Schägger, Hermann ^a   Ohm, Thomas Georg ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Alzheimer; blue native electrophoresis; F1Fo ATP synthase; oxidative phosphorylation; respiratory chain proteins

Indexed keywords

PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GEL ELECTROPHORESIS; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL;

ADENINE NUCLEOTIDES; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HIPPOCAMPUS; HUMAN; MALE; MEMBRANE PROTEINS; MIDDLE AGE; NAD; OXIDATIVE PHOSPHORYLATION; PROTON-TRANSLOCATING ATPASES; SUPPORT, NON-U.S. GOV'T;

EID: 0028869597     PISSN: 00142956     EISSN: 14321033     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1995.tb20219.x     Document Type: Article

References (28)

1. The mitochondrial electron transport and oxidative phosphorylation system
2. The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains
3. Progress in succinate:quinine oxidoreductase research
4. 1 complex from beef heart
5. On the function of multiple subunits of cytochrome c oxidase from higher eukaryotes
6. 0‐ATPase from bovine heart mitochondria
7. Mitochondrial genetics: a paradigm for aging and degenerative diseases
8. Cytochrome oxidase deficiency in Alzheimer's disease
9. Mitochondrial function in brain tissue in primary degenerative dementias
10. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
11. Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation
12. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer brains
13. Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease?
14. No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease
15. Mitochondrial DNA variants observed in Alzheimer's disease and Parkinson's disease patients
16. A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue
17. Neuropathological stageing of Alzheimer‐related changes
18. Silver staining of Alzheimer's neurofibrillary changes by means of physical development
19. Alzheimer's plaques and tangles: a controlled and enhanced silver staining method
20. A competition between silver‐stain and immunocytochemistry
21. Alzheimer's disease: mismatch between amyloid plaques and neuritic plaques
22. Blue native electrophoresis for isolation of membrane protein complexes in enzymically active form
23. Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two‐dimensional native electrophoresis
24. Metabolic alterations common to neural and non‐neural cells in Alzheimer's disease
25. The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease
26. Predominant abnormality in cerebral glucose utilization in late‐onset dementia of the Alzheimer type: a cross‐sectional comparison against advanced late‐onset and incipient early onset cases
27. Subacute necrotizing encephalopathy: oxidative phosphorylation defects and the ATPase 6 point mutation
28. Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease