Cyclic-AMP induction of gap junctional intercellular communication increases bystander effect in suicide gene therapy

Clinical Cancer Research

Volumn 5, Issue 1, 1999, Pages 61-68

  Carystinos, George D ^b   Katabi, Maha M ^b   Laird, Dale W ^c   Galipeau, Jacques ^a   Chan, Helen ^a   Alaoui Jamali, Moulay A ^a   Batist, Gerald ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; CONNEXIN 43; GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CELL KILLING; CONTROLLED STUDY; GAP JUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; SUICIDE GENE;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADENOVIRIDAE; ANIMALS; AVIAN SARCOMA VIRUSES; CELL COMMUNICATION; CONNEXIN 43; CYCLIC AMP; DNA, VIRAL; EXTRACELLULAR SPACE; GAP JUNCTIONS; GENE THERAPY; GENETIC VECTORS; MAMMARY NEOPLASMS, ANIMAL; MICE; TUMOR CELLS, CULTURED;

EID: 0032954435     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res., 46: 5276-5281, 1986.
2. Kozarsky, K. F., and Wilson, J. M. Gene therapy: adenovirus vectors. Curr. Opin. Genet. Dev., 3: 499-503, 1993.
3. Putzer, B. M., Bramson, J. L., Addison, C. L., Hitt, M., Siegel, P. M., Muller, W. J., and Graham, F. L. Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer. Hum. Gene Ther., 9: 707-718, 1998.
4. Freeman, S. M., Abboud, C. N., and Whartenby, K. A. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53: 5274-5283, 1993.
5. Fick, J., and Barker, F. G. The extent of heterocellular communication mediated gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc. Natl. Acad. Sci. USA, 92: 11071-11075, 1995.
6. Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K., and Yamasaki, H. Bystander killing of cancer cells by herpes virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. USA, 93: 1831-1835, 1996.
7. Elshami, A. A. Gap junctions play a role in the bystander effect of the herpes simplex thymidine kinase/ganciclovir system in vitro. Gene Ther., 3: 85-92, 1996.
8. Wygoda, M. R., Wilson, M. R., Davis, M. A., Trosko, J. E., Rehemtulla, A., and Lawrence, T. S. Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect. Cancer Res., 57: 1699-1703, 1997.
9. Lawrence, T. S., Rehemtulla, A., Ng, E. Y., Wilson, M., Trosko, J. E., and Stetson, P. L. Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine. Cancer Res., 58: 2588-2593, 1998.
10. Bruzzone, R., White, T. W., and Paul, D. L. Connections with connexins: the molecular basis of direct intercellular signaling. Eur. J. Biochem., 238: 1-27, 1996.
11. Goodenough, D. A., Goliger, J. A., and Paul, D. L. Connexons, connexins, and intercellular communication. Annu. Rev. Biochem., 65: 475-502, 1996.
12. Laird, D. W., Castillo, M., and Kasprzak, L. Gap junction turnover, intercellular trafficking and phosphorylation of Cx43 in brefeldin A-treated rat mammary tumor cells. J. Cell. Biol., 131: 1193-1203, 1995.
13. Yamasaki, H. Gap junctional intercellular communication and carcinogenesis. Carcinogenesis (Lond.), 11: 1051-1058, 1990.
14. Yamasaki, H., Mesnil, M., Omori, Y., Mironov, N., and Krutovskikh, V. Intercellular communication and Carcinogenesis. Mutat. Res., 333: 181-188, 1995.
15. Proulx, A. A., Xiang Lin, Z., and Naus, C. C. G. Transfection of Rhabdomyosarcoma cells with connexin43 induces myogenic differentiation. Cell Growth Differ., 8: 533-540, 1997.
16. Mehta, P. P., Hotz-Wagenblatt, A., Rose, B., Shalloway, D., and Loewestein, W. R. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth. J. Membr. Biol., 124: 207-225, 1991.
17. Dilber, M. S., Abedi, M. R., Christennson, B., Kidder, G., Naus, C., and Edvard Smith, C. I. Gap junctions promote the bystander effect of herpes virus thymidine kinase in vivo. Cancer Res., 57: 1523-1528, 1997.
18. Banoub, R. W., Fernstrom, M., Malkinson, A. M., and Ruch, R. J. Enhancement of gap junctional intercellular communication by dibutyryl cyclic AMP in lung epithelial cells. Anticancer Res., 16: 37153719, 1996.
19. Hossain, M., Bertram, J. S. Retinoids and gap junctions. Cell Growth Differ., 5: 1253-1261, 1994.
20. Stahl, W., Nicolai, S., Briviba, K., Hanusch, M., Broszeit, G., Peters, M., Martin, H. D., and Sies, H. Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis (Lond.), 18: 89-92, 1997.
21. Chen, T. C., Hinton, D. R., Zidovetzki, R., and Hofman, F. M. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest., 78: 165-174, 1998.
22. Monaghan, P., Clarke, C., Perusinghe, N. P., Moss, D. W., Chen, X. Y., and Evans, W. H. Gap junction distribution and connexin expression in human breast. Exp. Cell Res., 223: 29-38, 1996.
23. Lee, S. W., Tomasetto, J. C., Paul, D. L., and Sager, R. Transcriptional down-regulation of gap junction proteins blocks junctional communication in mammary cell lines. J. Cell Biol., 118: 1213-1221, 1992.
24. Laird, D. W., Castillo, M., and Kasprzak, L. Gap junction turnover, intercellular trafficking and phosphorylation of Cx43 in brefeldin A-treated rat mammary tumor cells. J. Cell. Biol., 737: 1193-1203, 1995.
25. Kiang, D. T., Kollander, R., Lin, H. H., LaVilla, S., and Atkinson, M. M. Measurement of gap junctional communication by fluorescence activated cell sorting. In Vitro Cell. Dev. Biol. Anim., 30A: 796-802, 1994.
26. Plumb, J. A., Miloy, R., and Kaye, S. B. Effects of the pH dependence on diphenyl-tetrazolium bromide-formazam absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res., 49: 4435-4440, 1989.
27. Yang, L., Chiang, Y., Lenz, H. J., Danenberg, K. D., Spears, C. P., Gordon, E. M., Anderson, W. F., and Parekh, D. Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells. Hum. Gene Ther., 9: 719-728, 1998.
28. Park, J. Y., Elshami, A. A., Amin, K., Rizk, N., Kaiser, L. R., and Albelda, S. M. Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy. Gene Ther., 4: 909-917, 1997.