Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677

Clinical Endocrinology

Volumn 50, Issue 4, 1999, Pages 451-456

  Svensson, Johan ^a   Carlsson, B ^a   Carlsson, L M S ^a   Jansson, J O ^a   Bengtsson, B Å ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GROWTH HORMONE; IBUTAMOREN; LEPTIN; LIOTHYRONINE; LUTEINIZING HORMONE; PLACEBO; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; THYROID HORMONE; THYROTROPIN;

ADULT; ANTHROPOMETRY; ARTICLE; BODY FAT; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FREE LIOTHYRONINE INDEX; HUMAN; MALE; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THYROTROPIN BLOOD LEVEL;

ADMINISTRATION, ORAL; ADULT; BODY COMPOSITION; CHOLAGOGUES AND CHOLERETICS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; GROWTH HORMONE; HUMANS; INDOLES; LEPTIN; LINEAR MODELS; MALE; MIDDLE AGED; OBESITY; PROTEINS; SPIRO COMPOUNDS; TESTOSTERONE; THYROTROPIN; TRIIODOTHYRONINE;

EID: 0032954247     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1999.00667.x     Document Type: Article

References (25)

1. Berneis, K., Vosmeer, S. & Keller, U. (1996) Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. European Journal of Endocrinology, 135,663-665.
2. Bianda, T., Glatz, Y., Boeni-Schnetzler, M., Froetsch, E. & Schmid, C. (1997) Effects of growth hormone (GH) and insulin-like growth factor-I on serum leptin in GH-deficient adults [Letter]. Diabetologia. 40, 363-364.
3. Chapman, I., Bach, M., Van Cauter, E., Farmer, M., Krupa, D., Taylor, A., Schilling, L., Cole, K., Skiles, E., Pezzoli, S., Hartrnan, M., Veldhuis, J., Gormley, G. & Thorner, M. (1996) Stimulation of the growth hormone (GH)-insulin-like growth factor-I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects. Journal of Clinical Endocrinology and Metabolism, 81, 4249-4257.
4. Chehab, F.F., Lim, M.E, & Lu, R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics, 12, 318-320.
5. Clark, J., Kalra, P., Crowley, W. & Kalra, S. (1984) Neuropeptide Y and human pancreatic polypeplide stimulate feeding in rats. Endocrinology, 115, 427-429.
6. Clark, R., Mortensen, D., Carlsson, L., Carlsson, B., Carmignac, D, & Robinson, I. (1996) The obese growth hormone (GH)-deficient dwarf rat: Body fat responses to patterned delivery of GH and insulin-like growth factor-I. Endocrinology, 137, 1904-1912.
7. Considine, R.V., Sinha, M.K., Heiman, M.L., Kriauciunas, A., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., McKee, L.J., Bauer, T.L. & Caro, J.F. (1996) Serum immuno-reactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, 334, 292-295.
8. Copinschi, G., Van Onderbergen, A.L., 'Hermite-Balériaux, M., Mendel, C., Caufriez, A., Leproult, R., Bolognese, J., De Smet, M., Thorner, M. & Van Cauter, E. (1996) Effects of a 7-day treatment with a novel, orally active growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor-I, and adenocortical function in normal young men. Journal of Clinical Endocrinology and Metabolism, 81, 2776-2782.
9. De Boer, H., Blok, G.-J. & Van Der Veen, E. (1995) Clinical aspects of growth hormone deficiency in adults Endocrine Reviews, 16, 63-86.
10. Dickson, S. & Luckman, S. (1997) Induction of c-fos mRNA in NPY and GRF neurones in the rat arcleus nucleus following systemic injection of the growth hormone secretagogue, GHRP-6. Endocrinology, 138, 771-777.
11. Fisker, S., Vahl, N., Hansen, T., Jorgensen, J., Hagen, C., Orskov, H. & Christiansen, J. (1997) Serum leplin is increased in growth hormone-deficient adults: relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year. Metabolism, 46, 812-817.
12. Florkowski, C.M., Collier, G.R., Zimmet, P.Z., Livesey, J.H., Espiner, E.A. & Donald, R.A. (1996) Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clinical Endocrinology, 45, 769-773.
13. Gafny, M., Silbergeld, A., Klinger, B., Wasserman, M. & Laron, Z,. (1994) Comparative effects of GH, IGF-I and insulin on serum sex hormone binding globulin. Clinical Endocrinology, 41, 169-175.
14. Johannsson, G., Mårin, P., Lönn, L., Ottosson, M., Stenlöf, K., Björntorp, P., Sjöström, L. & Bengtsson, B.-Ǎ. (1997) GH treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. Journal of Clinical Endocrinology und Metabolism, 82, 727-734.
15. Kraiem, Z., Bowers, C., Sobel, E. & Laron, Z. (1995) Growth hormone (GH)-releasing heptapeptide, but not GH-releasing hormone, inhibits thyrotropin-stimulated thyroid hormone secretion and cAMP formation in cultured human thyroid follicles. European Journal of Endocrinology, 133, 117-120.
16. Mattel, M., Halaas, J., Ravussin, E., Pratley, R.E., Lee, G.H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., Kern, P.A. & Friedman, J.M. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine, 1, 1155-1161.
17. Okada, K., Ishii, S., Minami, S., Sugihara, H., Shibasaki, T. & Wakabayashi, I. (1996) Intraventricular administration of the growth hormone releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology, 137, 5155-5158.
18. Oscarsson, J., Lindstedt, G., Lundberg, P. & Eden, S. (1996) Continuous subcutaneous infusion of low dose growth hormone decreases serum sex-hormone binding globulin and testosterone concentrations in moderately obese middle-aged men. Clinical Endocrinology, 44, 23-29.
19. Schwartz, M.W., Baskin, D.G., Bukowski, T.R., Kuijper, J.L., Foster, D., Lasser, G., Prunkard, D.E., Porte, D. Jr, Woods, S.C., Seeley, R.J. & Weigle, D.S. (1996) Specificity of leptin action on elevated blood glucose levels and hypolhalamic neuropeptide Y gene expression in ob/ob mice. Diabetes, 45, 531-535.
20. Screenan, S., Caro, J. & Refetoff, S. (1997) Thyroid dysfunction is not associated with alterations in serum leptin levels. Thyroid, 7, 407-409.
21. Svensson, J., Lönn, L., Jansson, J.-O., Murphy, G., Wyss, D., Krupa, D., Cerchio, K., Polvino, W., Gertz, B., Boseaus, I., Sjöström, L. & Bengtsson, B.-Å. (1998) Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. Journal of Clinical Endocrinology and Metabolism, 83, 362-369.
22. Valcavi, R., Zini, M., Peino, R., Casanueva, F.F. & Dieguez, C. (1997) Influence of thyroid status on serum immunoreactive leptin levels. Journal of Clinical Endocrinology and Metabolism, 82, 1632-1634.
23. Van den Berghe, G., de Zegher, F., Veldhuis, J., Wouters, P., Gouwy, S., Stockman, W., Weekers, F., Schetz, M., Lauwers, F., Bouillon, R. & Bowers, C. (1997) Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues. Clinical Endocrinology, 47, 599-612.
24. Veldhuis, J., Liem, A., South, S., Weltman, A., Weltman, J., Clemmons, D., Abbott, R., Mulligan, T., Johnson, M., Pincus, S., Straume, M. & Iranmanesh, A. (1995) Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. Journal of Clinical Endocrinology and Metabolism, 80, 3209-3222.
25. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.