Genetics of schizophrenia: Current findings and issues

CNS Spectrums

Volumn 4, Issue 5, 1999, Pages 17-21

  Kennedy, James L ^a,c   Pato, Michèle T ^a,b   Bauer, Amy ^a,b   Carvalho, Celia ^a,b   Pato, Carlos N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME MAP; DNA DETERMINATION; GENE LOCATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

EID: 0032937455     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1092852900011676     Document Type: Review

References (46)

1. Gottesman II, Shields J. Schizophrenia: The Epigenetic Puzzle. Cambridge, UK: Cambridge University Press; 1982.
2. Pato CN, Lander ES, Schultz SC. Prospects for the genetic analysis of schizophrenia. Schizophr Bull. 1989;15:365-372.
3. Pato CN, Azevedo MH, Pato MT, et al. Selection of homogeneous populations for genetic study: The Portuguese Genetics of Psychosis Project. Am J Med Genet. 1997;74:286-288.
4. Tsuang MT, Faraone SV. The Genetics of Mood Disorders. Baltimore, Md: Johns Hopkins; 1990.
5. Faraone SV, Kremen WS, Tsuang MT. Genetic transmission of major affective disorders: quantitative models and linkage analyses. Psychol Bull. 1990;108:109-127.
6. Greenberg DA. There is more than one way to collect data for linkage analysis: what a study of epilepsy can tell us about linkage strategy for psychiatric disease. Arch Gen Psychiatry. 1992;49:745-750.
7. Goldin LR. The increase in type 1 error rates in linkage studies when multiple analyses are carried out on the same data: a simulation study [abstract]. Am J Hum Genet. 1990;47:A180.
8. Goldin LR, Weeks DE. Two-locus models of disease: comparison of likelihood and nonparametric methods [abstract]. Am J Hum Genet. 1993;53(suppl):1006.
9. Weeks DE, Lehner T, Squires-Wheeler E, Kaufmann C, Ölt J. Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis. Genet Epidemiol. 1990;7:237-243.
10. Risch N. Linkage strategies for genetically complex traits: II. The power of affected relative pairs. Am ] Hum Genet. 1990;46:229-241.
11. Falk CT, Rubenstein P. Haplotype relative risk: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet. 1987;51:227-233. j
12. Terwilliger JD, Ott J. A haplotype-based "haplotype relative risk" approach to detecting allele associations. Hum tiered. 1992;42:337-346.
13. Kruglyak L, Daly M, Daly MPR, Lander E. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996;58:1347-1363.
14. Sträub RE, MacLean CJ, O'Neill FA, et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet. 1995;ll:287-293.
15. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Aal Genet. 1995;! 1:241-247.
16. Kennedy JL. Molecular genetics of the dopamine receptor genes and schizophrenia. In: Niznik HB, ed. Dopamine Receptors and Transporters. New York, NY: Marcel Dekker, 1993:581-593.
17. Kennedy JL, Billett EA, Macciardi FM, et al. Association study of dopamine D3 receptor gene and schizophrenia. Am J Med Genet. 1995;60:558-562.
18. Dourado A, Coelho I, Macedo A, et al. Association study of DRD3 and schizophrenia in Portuguese patients: effect of population stratification. Psiquiatria Clinica. 1997;18:49-53.
19. Williams J, Spurlock G, Holmans P, et al. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry. 1998;3:141-149.
20. Coelho I, Macedo A, Valante J. Association study of serotonin receptors and schizophrenia in a Portuguese population. Psiquiatria Clinica. 1997;18:41-47.
21. Williams J, McGuffin P, Nothen M, Owen MJ. Metaanalysis of association between the 5-HT2t receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study of Schizophrenia. Lancet. 1997;26:122.
22. Vicente AM, Kennedy JL. The genetics of neurodevelopment and schizophrenia. In: Keshavan M, Murray RM, eds. Neurodetelopment and Adult Psychopathology. Cambridge, UK: Cambridge University Press; 1997:3156.
23. Freedman R, Coon H, Myles-Worsley M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA. 1997;94:587-592.
24. Chandy KG, Fantino E, Wittekindt O, et al. Isolation of a novel potassium channel gene hSKCaS containing a polymorphic GAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry. 1998;3:32-37.
25. Kendler KS, Diehl SR. The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull. 1993;19:261-285.
26. Karayiorgou M, Gogos JA. Dissecting the genetic complexity of schizophrenia. Mol Psychiatry. 1997;2:211223.
27. Levinson DF, Mahtani MM, Nancarrow DJ, et al. \ Genome scan of schizophrenia. Am J Psychiatry. \ 1998;155:741-750.
28. ! 28. Sträub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler I KS. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol I Psychiatry. 1997;2:148-155.
29. Schwab SG, Eckstein GN, Hallmayer J, et al. Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Mol Psychiatry. 1997;2:156-160.
30. Cao Q, Martinez M, Zhang J, et al. Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. Genomics. 1997;43:l-8.
31. Diehl SR, Wang S, Detera-Wadleigh S, et al. Evidence suggesting possible SCA1 gene involvement in schizophrenia. Am J Hum Genet. 1994;55S:867.
32. Moises HW, Yang L, Kristbjamarson H, et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet. 1995;ll:321-324.
33. Schizophrenia Linkage Collaborative Group for Chromosomes 3,6, and 8. Additional support for schizophrenia linkage on chromosomes 6 and 8: a mullicenter study. Am JMed Genet. 1996;67:580-594.
34. Pulver AE, Lasseter VK, Kasch L, et al. Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am ] Med Genet. 1995;60:252-260.
35. Kendler KS, MacLean CJ, O'Neill FA, et al. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry. 1996;153:1534-1540.
36. Faraone SV, Matise T, Svrakic DM, et al. Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet. 1998;81:290-295.
37. Sträub RE, MacLean CJ, Martin RB, et al. A schizophrenia locus may be located in region lOpl5-ll.Am J Med Genet. 1998;81:296-301.
38. Maziade M, Raymond V, Cliche D, et al. Linkage results on 11Q21-22 in Eastern Quebec pedigrees densely affected by schizophrenia. Am J Med Genet. 1995;60:522-528.
39. Lin M\P, Sham P, Hwu HG, Collier D, Murray R, Powell JF. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations. Hum Genet. 1997;99:417-420.
40. Wildenauer DB, Schwab SG, Hallmayer J, et al. Genome scan for autosomal genes confering risk to schizophrenia in a German/Israeli sample [abstract]. Am J Med Genet. 1998;81:454.
41. Gill M, Vallada H, Collier D, et al. A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22ql2. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet. 1996;67:4045.
42. Dann J, DeLisi LE, Devoto M, et al. A linkage study of schizophrenia to markers within Xpll near the MAOB gene. Psychiatry Res. 1997;70:131-143.
43. Moldin SO. The maddening hunt for madness genes. Nat Genet. 1997;17:127-129.
44. Delepine M, Pociot F, Habita C, et al. Evidence of a nonMHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. Am J Hum Genet. 1998;60:174187.
45. Cloninger CR, Kauffman CA, Faraone SV, et al. Genome-wide search for schizophrenia susceptibility loci: The- NIMH Genetics Initiative and Millennium Consortium. AmJMed Genet. 1998;81:275-281.
46. Kauffman CA, Suarez B, Malaspina D, et al. NIMH Genetics Initiative Millennium Consortium: linkage analysis of African-American pedigrees. Am J Med Genet. 1998;81:282-289.