An investigation into the structural determinants of cannabinoid receptor ligand efficacy

British Journal of Pharmacology

Volumn 126, Issue 7, 1999, Pages 1575-1584

  Griffin, Graeme ^a   Wray, Emma J ^a   Rorrer, William K ^a   Crocker, Peter J ^b   Ryan, William J ^b   Saha, Bijali ^b   Razdan, Raj K ^b   Martin, Billy R ^a   Abood, Mary E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ORGANIX INC   (United States)

Author keywords

Agonist; Antagonist; Cannabinoid receptors; Efficacy; G proteins; Partial agonist; Rat cerebellum; 35S GTP S binding

Indexed keywords

CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); O 1125; O 1176; O 1184; O 1236; O 1237; O 1238; O 584; O 806; O 823; PARTIAL AGONIST; RIMONABANT; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CEREBELLUM; CONTROLLED STUDY; COVALENT BOND; DRUG STRUCTURE; LIGAND BINDING; MALE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032928552     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702469     Document Type: Article

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