Agonist-antagonist characterization of 6'-cyanohex-2'-yne-Δ8-tetrahydrocannabinol in two isolated tissue preparations

European Journal of Pharmacology

Volumn 315, Issue 2, 1996, Pages 195-201

  Pertwee, Roger G ^a   Fernando, Susanthi R ^a   Griffin, Graeme ^a   Ryan, William ^b   Razdan, Raj K ^b   Compton, David R ^c   Martin, Billy R ^c  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ORGANIX INC   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

6' Cyanohex 2' yne 8 tetrahydrocannabinol; Cannabinoid receptor antagonist; Cannabinoid receptor partial agonist; Myenteric plexus longitudinal muscle preparation; O 823; Small intestine, guinea pig; SR141716A; Vas deferens, mouse

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID; CANNABINOID RECEPTOR; DRONABINOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GUINEA PIG; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; SMOOTH MUSCLE TONE; VAS DEFERENS;

ANALGESICS; ANIMALS; BINDING, COMPETITIVE; CYCLOHEXANOLS; GUINEA PIGS; INJECTIONS, INTRAPERITONEAL; INTESTINE, SMALL; MALE; MICE; MORPHOLINES; MUSCLE CONTRACTION; NAPHTHALENES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL; VAS DEFERENS;

EID: 0030583698     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00631-0     Document Type: Article

References (16)

1. Colquhoun, D., 1971, Lectures on Biostatistics (Oxford University Press, Oxford).
2. Compton, D.R., K.C. Rice, B. De Costa, R.K. Razdan, L.S. Melvin, M.R. Johnson and B.R. Martin, 1993, Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities, J. Pharmacol. Exp. Ther. 265, 218.
3. 9-tetrahydrocannabinol treatment, Pharmacol. Biochem. Behav. 47, 33.
4. Devane, W.A., F.A. Dysarz, M.R. Johnson, L.S. Melvin and A.C. Howlett, 1988, Determination and characterization of a cannabinoid receptor in rat brain, Mol. Pharmacol. 34, 605.
5. Hollister, L.E., 1986, Health aspects of cannabis, Pharmacol. Rev. 38, 1.
6. Martin, B.R., B.F. Thomas and R.K. Razdan, 1995, Structural requirements for cannabinoid receptor probes, in: Cannabinoid Receptors, ed. R.G. Pertwee (Academic Press, London) p. 35.
7. Oviedo, A., J. Glowa and M. Herkenham, 1993, Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study, Brain Res. 616, 293.
8. Paterson, S.J. and R.G. Pertwee, 1993, Characterization of the cannabinoid binding site in the guinea-pig, Br. J. Pharmacol. (Proceedings Suppl.) 109, 82P.
9. Paton, W.D.M. and M.A. Zar, 1968, The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips, J. Physiol. 194, 13.
10. Pertwee, R.G., 1995, Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors: an overview, in: Cannabinoid Receptors, ed. R.G. Pertwee (Academic Press, London) p. 1.
11. Pertwee, R.G., L.A. Stevenson, D.B. Elrick, R. Mechoulam and A.D. Corbett, 1992, Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea-pig small intestine, Br. J. Pharmacol. 105, 980.
12. Pertwee, R.G., L.A. Stevenson and G. Griffin, 1993, Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide, Br. J. Pharmacol. 110, 1483.
13. Pertwee, R.G., G. Griffin, J.A.H. Lainton and J.W. Huffman, 1995, Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens, Eur. J. Pharmacol. 284, 241.
14. 1 receptors in guinea-pig small intestine, Br. J. Pharmacol. 118, 2199.
15. Rinaldi-Carmona, M., F. Barth, M. Héaulme, D. Shire, B. Calandra, C. Congy, S. Martinez, J. Maruani, G. Néliat, D. Caput, P. Ferrara, P. Soubrié, J.-C. Brelière and G. Le Fur, 1994, SR141716A, a potent and selective antagonist of the brain cannabinoid receptor, FEBS Lett. 350, 240.
16. 2 and receptor differentiation: a statistical analysis of competitive antagonism, Life Sci. 25, 637.